2-Phthalimidoethanesulfonyl chloride
- CAS No.
- 4403-36-5
- Chemical Name:
- 2-Phthalimidoethanesulfonyl chloride
- Synonyms
- 2-(1,3-dioxoisoindolin-2-yl)ethane-1-sulfonyl chloride;AKOS MSC-0752;AKOS BBS-00004578;2-Phthalimidoethanesulfonyl chlorid;2-Phthalimidoethanesulfonyl chloride;2-Phthalimidoethanesulfonyl chloride - [P3032];2H-Isoindole-2-ethanesulfonyl chloride, 1,3-dihydro-1,3-dioxo-;2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ETHANESULFONYL CHLORIDE;2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethane-1-sulfonyl chloride;2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-ethanesulfonyl chloride
- CBNumber:
- CB5740934
- Molecular Formula:
- C10H8ClNO4S
- Molecular Weight:
- 273.69
- MDL Number:
- MFCD01861217
- MOL File:
- 4403-36-5.mol
- MSDS File:
- SDS
| Melting point | 158-163℃ |
|---|---|
| Boiling point | 416.5±28.0 °C(Predicted) |
| Density | 1.585±0.06 g/cm3(Predicted) |
| vapor pressure | 0-0Pa at 20-50℃ |
| storage temp. | 2-8°C |
| pka | -2.47±0.20(Predicted) |
| form | Slurry |
| color | Yellow to orange to brown |
| Water Solubility | Reacts with water. |
| Sensitive | Moisture Sensitive |
| Stability | Hygroscopic, Moisture Sensitive |
| InChI | 1S/C10H8ClNO4S/c11-17(15,16)6-5-12-9(13)7-3-1-2-4-8(7)10(12)14/h1-4H,5-6H2 |
| InChIKey | HCPVYBCAYPMANM-UHFFFAOYSA-N |
| SMILES | ClS(=O)(=O)CCN1C(=O)c2ccccc2C1=O |
| LogP | 1.12-2.44 at 25℃ |
| CAS DataBase Reference | 4403-36-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45-60 | |||||||||
| RIDADR | 3261 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29251900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Skin Sens. 1 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2-Phthalimidoethanesulfonyl chloride price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 739820 | 2-Phthalimidoethanesulfonyl chloride 95% | 4403-36-5 | 1g | $85.2 | 2023-06-20 | Buy |
| TCI Chemical | P2049 | 2-Phthalimidoethanesulfonyl Chloride >98.0%(T) | 4403-36-5 | 1g | $76 | 2026-04-30 | Buy |
| TCI Chemical | P2049 | 2-Phthalimidoethanesulfonyl Chloride >98.0%(T) | 4403-36-5 | 5g | $224 | 2026-04-30 | Buy |
| TRC | TRC-P400908-5G | 2-Phthalimidoethanesulfonyl chloride | 4403-36-5 | 5g | $314 | 2026-06-03 | Buy |
| TRC | TRC-P400908-1G | 2-Phthalimidoethanesulfonyl chloride | 4403-36-5 | 1g | $96 | 2026-06-03 | Buy |
2-Phthalimidoethanesulfonyl chloride Chemical Properties, Uses, Production
Uses
2-(Phthalimido)ethanesulfonyl chloride is an important raw material and intermediate used in pharmaceuticals, agro based and dye stuff fields.
Synthesis
85-44-9
107-35-7
4403-36-5
The general procedure for the synthesis of 2-phenylenedi(meth)iminoethane sulfonyl chloride from phthalic anhydride and taurine is as follows:1. A suspension of taurine (8.0 g, 63.9 mmol) and potassium acetate (6.7 g, 68.3 mmol) was refluxed in acetic acid for 15 min. 2. Phthalic anhydride (10.1 g, 68.4 mmol) was added, and the reaction was continued to be refluxed for 3 h. 3. Upon completion of the reaction, the reaction was cooled to room temperature, the solid product was collected by filtration, washed with cold acetic acid and dried under vacuum at 100 °C to give a white solid.4. The above white solid (14.3 g, 54.7 mmol) was suspended in toluene (50 ml), and phosphorus pentachloride (8.12 g, 39.0 mmol) was added under the protection of nitrogen.5. After the reaction mixture was heated and refluxed for 1 hour The reaction mixture was heated and refluxed for 1 hour, then phosphorus pentachloride (8.12 g, 39.0 mmol) was added again and refluxing was continued for another 2.5 hours.6 Upon completion of the reaction, a brownish solution was poured from a small amount of the solid formed, and the solution was subsequently concentrated under vacuum.7 The concentrated residue was poured into a mixture of ice and water (ice:water=50:50, 100 ml), and the solid product was filtered to collect the solid product.8 Finally, the solid was dried under vacuum at 45°C for 16 hours to obtain a light brown color.9 The reaction was carried out under nitrogen protection. Vacuum dried for 16 hours to give a light brown solid product (6.4 g, 34% yield).
References
[1] Patent: US6313312, 2001, B1
[2] Archiv der Pharmazie, 2007, vol. 340, # 12, p. 656 - 660
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 6, p. 2390 - 2400
[4] European Journal of Medicinal Chemistry, 2018, vol. 146, p. 108 - 122
2-Phthalimidoethanesulfonyl chloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2712 | 61 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Latest Price from 2-Phthalimidoethanesulfonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | 2-PHTHALIMIDOETHANESULFONYL CHLORIDE
4403-36-5
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 2-PHTHALIMIDOETHANESULFONYL CHLORIDE
4403-36-5
- $1.00
- 99%
- Career Henan Chemical Co
