Ethyl 2-cyanopyridine-3-carboxylate
- CAS No.
- 75358-90-6
- Chemical Name:
- Ethyl 2-cyanopyridine-3-carboxylate
- Synonyms
- ethyl 2-cyanonicotinate;Ethyl 2-cyanonicotinate 97+%;2-Cyano-nicotinic acid ethyl ester;Ethyl 2-cyanopyridine-3-carboxylate;Ethyl 2-cyanopyridine-3-carboxylate 97%;3-(Ethoxycarbonyl)-2-pyridinecarbonitrile;2-cyano-3-pyridinecarboxylic acid ethyl ester;2-Cyanopyridine-3-carboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 2-cyano-, ethyl ester
- CBNumber:
- CB5770771
- Molecular Formula:
- C9H8N2O2
- Molecular Weight:
- 176.17
- MDL Number:
- MFCD07368152
- MOL File:
- 75358-90-6.mol
- MSDS File:
- SDS
| Melting point | 35-40°C |
|---|---|
| Boiling point | 185-195 °C(Press: 12 Torr) |
| Density | 1.21 |
| storage temp. | 2-8°C |
| pka | -2.25±0.10(Predicted) |
| form | solid |
| Appearance | Off-white to light yellow Solid |
| InChI | 1S/C9H8N2O2/c1-2-13-9(12)7-4-3-5-11-8(7)6-10/h3-5H,2H2,1H3 |
| InChIKey | KOAWFXMHARNHJY-UHFFFAOYSA-N |
| SMILES | CCOC(C1=C(C#N)N=CC=C1)=O |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| target organs | Respiratory system |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 36/37/39 |
| WGK Germany | 3 |
| HS Code | 2933399990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
Ethyl 2-cyanopyridine-3-carboxylate price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 791237 | Ethyl 2-cyanopyridine-3-carboxylate 97% | 75358-90-6 | 250mg | $72.3 | 2023-06-20 | Buy |
| Apolloscientific | OR301301 | Ethyl 2-cyanonicotinate >97% | 75358-90-6 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR301301 | Ethyl 2-cyanonicotinate >97% | 75358-90-6 | 1g | $29 | 2026-06-04 | Buy |
| Apolloscientific | OR301301 | Ethyl 2-cyanonicotinate >97% | 75358-90-6 | 5g | $137 | 2026-06-04 | Buy |
| Apolloscientific | OR301301 | Ethyl 2-cyanonicotinate >97% | 75358-90-6 | 25g | $672 | 2026-06-04 | Buy |
Ethyl 2-cyanopyridine-3-carboxylate Chemical Properties, Uses, Production
Synthesis
557-21-1
1452-94-4
75358-90-6
To a solution of ethyl 2-chloropyridine-3-carboxylate (15.0 g, 81 mmol) in anhydrous N,N-dimethylacetamide (75 mL) was added zinc cyanide (5.71 g, 48.6 mmol), tris(dibenzylideneacetone)dipalladium (742 mg, 0.81 mmol), zinc powder (636 mg, 9.72 mmol), and 1,1'-bis(diphenylphosphinyl ) ferrocene (898 mg, 1.62 mmol). The reaction mixture was heated and stirred at 120 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and then partitioned between water (300 mL) and ether (150 mL). The organic and aqueous phases were separated by Celite filtration of the mixture. The aqueous phase was further extracted with ether (2 x 100 mL), all ether layers were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give ethyl 2-cyanonicotinate (14.26 g, 100% yield).
References
[1] Patent: WO2004/46133, 2004, A1. Location in patent: Page 31
Ethyl 2-cyanopyridine-3-carboxylate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Shanghai potentpharm CO.,Ltd | 13524892556 | sales-cn@potentpharm.com | China | 1011 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8135 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| NovoChemy Ltd. | 86-(0)21-31261262 373522135 | sales@novochemy.com | China | 6491 | 58 |
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