4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride
- CAS No.
- 84449-80-9
- Chemical Name:
- 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride
- Synonyms
- Einecs 282-882-9;4-[2-(1-Pipiridine)e;Raloxifene Impurity 6;Raloxifene side chain;Raloxifene Benzoic Acid Impurity;Raloxifene Impurity(Hydrochloride）;4-[2-(1-piperidyl) ethoxy] benzoate;4-(2-PIPERIDINOETHOXY)BENZOIC ACID HCL;4-[2-(1-Pipiridine)Ethody]BenzoicAcidHcl;4-{2-(1-Piperidino)ethoxy}benzoic acid HCl
- CBNumber:
- CB5774865
- Molecular Formula:
- C14H20ClNO3
- Molecular Weight:
- 285.77
- MDL Number:
- MFCD06657755
- MOL File:
- 84449-80-9.mol
- MSDS File:
- SDS
| Melting point | 267-271°C dec. |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White |
| InChI | InChI=1S/C14H19NO3.ClH/c16-14(17)12-4-6-13(7-5-12)18-11-10-15-8-2-1-3-9-15;/h4-7H,1-3,8-11H2,(H,16,17);1H |
| InChIKey | CMVTYSMYHSVDIU-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(OCCN2CCCCC2)C=C1.[H]Cl |
| CAS DataBase Reference | 84449-80-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c |
| REACH Registrations | Active |
4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-P482025-25MG | 4-[2-(1-Piperidinyl)ethoxy]benzoic Acid Hydrochloride Salt | 84449-80-9 | 25mg | $167 | 2026-06-03 | Buy |
| TRC | TRC-P482025-250MG | 4-[2-(1-Piperidinyl)ethoxy]benzoic Acid Hydrochloride Salt | 84449-80-9 | 250mg | $351 | 2026-06-03 | Buy |
| TRC | TRC-P482025-1G | 4-[2-(1-Piperidinyl)ethoxy]benzoic Acid Hydrochloride Salt | 84449-80-9 | 1g | $734 | 2026-06-03 | Buy |
| AK Scientific | J52043 | 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride 95% | 84449-80-9 | 1g | $12 | 2026-06-04 | Buy |
| AK Scientific | J52043 | 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride 95% | 84449-80-9 | 5g | $17 | 2026-06-04 | Buy |
4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride Chemical Properties, Uses, Production
Chemical Properties
White Solid
Uses
An intermediate in the synthesis of Raloxifene hydrochloride.
Synthesis
![Benzoic acid, 4-[2-(1-piperidinyl)ethoxy]-, ethyl ester](/CAS/20210305/GIF/93148-78-8.gif)
93148-78-8
2008-75-5
99-76-3
84449-80-9
Example 4 Preparation of 4-[2-piperidine-1-ethoxy]benzoic acid hydrochloride A mechanical stirrer, condenser tube and a heating unit comprising a heating jacket connected via a temperature controller and an RTD temperature probe were assembled in a 250 mL three-neck flask and operated under nitrogen protection. 7.61 g of methyl 4-hydroxybenzoate (nipagin methyl ester), 11.05 g of 1-(2-chloroethyl)piperidine hydrochloride, 16.59 g of powdered potassium carbonate and 60 mL of isopropyl acetate were added sequentially. The reaction mixture was slowly heated to 80 °C and after 5 hours of reaction, high performance liquid chromatography (HPLC) analysis showed that the reaction was 90% complete. The reaction was continued at 80 °C overnight to ensure complete reaction. Upon completion of the reaction, the mixture was cooled to room temperature, 60 mL of deionized water was added and stirred until all solids were dissolved. The aqueous layer was separated and discarded. The organic layer was extracted three times with 20 mL of 4N hydrochloric acid solution. The extracts containing ethyl 4-[2-piperidin-1-ethoxy]benzoate were combined and heated to reflux (92°C for about 30 minutes to reach reflux). After refluxing for 7.5 hours, about 10 mL of water was removed by distillation, followed by cooling the mixture in an ice bath for 15 minutes. The precipitated 4-[2-piperidine-1-ethoxy]benzoic acid hydrochloride crystals were collected by filtration, washed with acetone and dried. A final product of 12.53 g was obtained in 87.7% yield of the theoretical value.
References
[1] Patent: US5631369, 1997, A
4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Sichuan Ruibo Technology Co., Ltd | +86-817-5586080 | China | 41 | 69 | |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 |
View Latest Price from 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride
84449-80-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-06-08 | 4-(2-(piperidin-1-yl)ethoxy)benzoic acid hydrochloride
84449-80-9
|
1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. | ||
 |
2019-12-25 | 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride
84449-80-9
|
1KG | 95%-99% | 1kg; 50kg; 500kg | Career Henan Chemical Co |
-
- 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride
84449-80-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 4-(2-(piperidin-1-yl)ethoxy)benzoic acid hydrochloride
84449-80-9
- 99%
- Jinan Ruitong Biotech Co., Ltd.
-
- 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride
84449-80-9
- $0.10
- 95%-99%
- Career Henan Chemical Co
