DY131
- CAS No.
- 95167-41-2
- Chemical Name:
- DY131
- Synonyms
- GSK4716;DY131;GW4716;CS-889;CS-2176;GW574716;GSK 9089;DY131 ，S5364;DY-131; DY 131;DY131(GSK 9089)
- CBNumber:
- CB5774966
- Molecular Formula:
- C18H21N3O2
- Molecular Weight:
- 311.38
- MDL Number:
- MFCD00715585
- MOL File:
- 95167-41-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 234-236 °C |
|---|---|
| Density | 1.11±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: ≥14 mg/mL |
| form | solid |
| pka | 8.47±0.15(Predicted) |
| color | yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChI | InChI=1S/C18H21N3O2/c1-3-21(4-2)16-9-5-14(6-10-16)13-19-20-18(23)15-7-11-17(22)12-8-15/h5-13,22H,3-4H2,1-2H3,(H,20,23) |
| InChIKey | WLKOCYWYAWBGKY-UHFFFAOYSA-N |
| SMILES | C(NN=CC1=CC=C(N(CC)CC)C=C1)(=O)C1=CC=C(O)C=C1 |
| FDA UNII | 5VWV92039E |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
DY131 price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D3946 | DY 131 ≥98% (HPLC) | 95167-41-2 | 5mg | $99.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | D3946 | DY 131 ≥98% (HPLC) | 95167-41-2 | 25mg | $338 | 2023-01-07 | Buy |
| TCI Chemical | D6368 | DY 131 | 95167-41-2 | 50MG | $73 | 2026-04-30 | Buy |
| Cayman Chemical | 17999 | DY 131 ≥98% | 95167-41-2 | 5mg | $68 | 2026-04-30 | Buy |
| Cayman Chemical | 17999 | DY 131 ≥98% | 95167-41-2 | 10mg | $118 | 2026-04-30 | Buy |
DY131 Chemical Properties, Uses, Production
Description
DY131 (95167-41-2) is a selective agonist at estrogen-related receptors ERRβ and ERRγ with minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.1Displays antiproliferative activity in prostate cancer cells.2Promotes hormone production and cell fusion in cytotrophoblasts.3In breast cancer cells DY131 arrests cells in G2/M and causes mitotic spindle defects.4Inhibits osteoclastogenesis and protects against inflammatory bone loss induced by LPSin vivo.5
Uses
DY131 is a selective estrogen-related receptors (ERRβ and ERRγ) agonist (1,2). It is also an antimitotic agent that inhibits breast cancer cell growth.
Definition
ChEBI: N-[[4-(diethylamino)phenyl]methylideneamino]-4-hydroxybenzamide is a member of benzoic acids.
Biological Activity
Novel selective agonist at estrogen-related receptors ERR β and ERR γ . Displays minimal activity at ERR α , ER α and ER β at concentrations up to 30 μ M.
in vitro
dy131 was evaluated for its selectivity and efficacy in modulating the transcriptional activity of errα/β/γ and erβ/γ. cv-1 cells were transfected with reporter constructs or expression vectors and the fold activation of the reporter construct was determined at different concentrations of dy131. dy131 was found to be not able to activate the reporter construct or errα at any of the tested concentrations. in contrast, dy131 led to three- to fourfold activation of errβ at concentrations of 10-30 μm. activity on errγ was more pronounced with five-fold activation at 3 μm and maximal 6.6-fold activity observed at 30 μm. thus, dy131 was an selective errβ/γ ligand displaying preferential selectivity for errγ at lower concentrations [1].
storage
+4°C
References
[1] DONNA D. YU Barry M F. Identification of an agonist ligand for estrogen-related receptors ERRβ/γ[J]. Bioorganic & Medicinal Chemistry Letters, 2005, 15 5: Pages 1311-1313. DOI:10.1016/j.bmcl.2005.01.025
[2] S YU. Orphan nuclear receptor estrogen-related receptor-β suppresses in vitro and in vivo growth of prostate cancer cells via p21WAF1/CIP1 induction and as a potential therapeutic target in prostate cancer[J]. Oncogene, 2007, 27 23: 3313-3328. DOI:10.1038/sj.onc.1210986
[3] DOROTHÉE POIDATZ. Trophoblast syncytialisation necessitates mitochondrial function through estrogen-related receptor-γ activation.[J]. Molecular human reproduction, 2015, 21 2: 206-216. DOI:10.1093/molehr/gau102
[4] MARY M HECKLER. Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer.[J]. Oncotarget, 2016: 47201-47220. DOI:10.18632/oncotarget.9719
[5] HYUN-JU KIM. Estrogen-related receptor γ negatively regulates osteoclastogenesis and protects against inflammatory bone loss[J]. Journal of Cellular Physiology, 2018, 234 2: 1659-1670. DOI:10.1002/jcp.27035
DY131 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yichang Chanod Biomedical Technology Co,LTD | 0717-6855399 15377615856 | sales@chanodpharm.com | China | 70 | 58 |
| Zhuhai Huachen Pharmaceutical Technology Co., Ltd | 15916275916 | 290113728@qq.com | China | 53 | 58 |
| Shandong kelikang drug co., ltd | 053-88113608 17854192669 | sales07@pharmachemm.com | China | 149 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
View Latest Price from DY131 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | DY131
95167-41-2
|
1kg | 99% | 20ton | Jinan Jianfeng Chemical Co., Ltd | ||
 |
2026-08-25 | DY131
95167-41-2
|
10g | 99% | 50kg | Xi an Biohorlden Industry Trade Co Ltd | ||
 |
2026-07-27 | DY131
95167-41-2
|
$47.00-156.00 | 98.65% | 10g | TargetMol Chemicals Inc. |
