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ChemicalBook >> CAS DataBase List >>1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]-

1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]-

1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Structure
1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- structure
CAS No.
2437475-16-4
Chemical Name:
1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]-
Synonyms
T6167923,T-6167923;T6167923, 10 mM in DMSO;TChemicalbook6167923,10mMinDMSO;(S)-4-((3-Bromophenyl)sulfonyl)-N-(1-(thiophen-2-yl)ethyl)piperazine;1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]-;(S)-4-((3-Bromophenyl)sulfonyl)-N-(1-(thiophen-2-yl)ethyl)piperazine-1-carboxamide
CBNumber:
CB58250482
Molecular Formula:
C17H20BrN3O3S2
Molecular Weight:
458.39
MDL Number:
MFCD30532664
MOL File:
2437475-16-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Properties

Density 1.530±0.06 g/cm3(Predicted)
pka 12.87±0.20(Predicted)
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0016557 T6167923 99.40% 2437475-16-4 5mg $301 2026-06-04 Buy
ChemScene CS-0016557 T6167923 99.40% 2437475-16-4 10mg $452 2026-06-04 Buy
ChemScene CS-0016557 T6167923 99.40% 2437475-16-4 25mg $799 2026-06-04 Buy
ChemScene CS-0016557 T6167923 99.40% 2437475-16-4 50mg $1062 2026-06-04 Buy
ChemScene CS-0016557 T6167923 99.40% 2437475-16-4 100mg $1462 2026-06-04 Buy
Product number Packaging Price Buy
CS-0016557 5mg $301 Buy
CS-0016557 10mg $452 Buy
CS-0016557 25mg $799 Buy
CS-0016557 50mg $1062 Buy
CS-0016557 100mg $1462 Buy

1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Chemical Properties, Uses, Production

Uses

T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively[1][2].

in vivo

T6167923 (0.17 and 1 mg; i.p. once) survives the mice from intoxication with SEB and LPS injection[2].

Animal Model:16-20 week-old BALB/c mice with LPS potentiation model[2]
Dosage:0.17 and 1 mg
Administration:Intraperitoneal injection; 0.17 and 1 mg once
Result:Dose-dependently showed a therapeutic efficacy against SEB intoxication.

References

[1] Saqib U, et al. Identifying the inhibition of TIR proteins involved in TLR signalling as an anti-inflammatory strategy. SAR QSAR Environ Res. 2018 Apr;29(4):295-318. DOI:10.1080/1062936X.2018.1431308
[2] Olson MA, et al. Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen. Sci Rep. 2015 Sep 18;5:14246. DOI:10.1038/srep14246

1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Suppliers

Global Suppliers ( 22)
Supplier Tel Email Country ProdList Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Nantong Hi-Future Biotechnology Co., Ltd +86-0513; 18051384581 sales@chemhifuture.com China 3075 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
InvivoChem 13549236410 sales@invivochem.cn China 6745 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939 shenlinxing@macklin.cn China 29676 58
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 18100677375 sales@szzxbio.com China 1129 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Supplier Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 60
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Nantong Hi-Future Biotechnology Co., Ltd 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Shanghai Maclean Biochemical Technology Co., LTD 58
Suzhou Zhixin Biotechnology Co., Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Latest Price from 1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
T6167923 pictures 2026-07-27 T6167923
2437475-16-4
 $93.00-343.00 99.28% 10g TargetMol Chemicals Inc.
T6167923 pictures 2026-07-27 T6167923
2437475-16-4
 $93.00-343.00 99.28% 10g TargetMol Chemicals Inc.
  • T6167923 pictures
  • T6167923
    2437475-16-4
  • $93.00-343.00
  • 99.28%
  • TargetMol Chemicals Inc.
  • T6167923 pictures
  • T6167923
    2437475-16-4
  • $93.00-343.00
  • 99.28%
  • TargetMol Chemicals Inc.

1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Spectrum

1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]-(2437475-16-4)1HNMR

2437475-16-4 (1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]-) Related Search:

4-(3-sulfanylbenzenesulfonyl)-N-[1-(thiophen-2-yl)ethyl]piperazine-1-carboxamide 4-((3-bromophenyl)sulfonyl)-N-(1-(thiophen-2-yl)ethyl)piperazine-1-carboxamide 1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- 6-Methoxyflavone 6,6'-Dibehenoyl-alpha,alpha'-trehalose
MyD88-IN-3

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1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- T6167923,T-6167923 T6167923, 10 mM in DMSO (S)-4-((3-Bromophenyl)sulfonyl)-N-(1-(thiophen-2-yl)ethyl)piperazine-1-carboxamide (S)-4-((3-Bromophenyl)sulfonyl)-N-(1-(thiophen-2-yl)ethyl)piperazine TChemicalbook6167923,10mMinDMSO 2437475-16-4