ChemicalBook >> CAS DataBase List >>(6aS-Trans)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide

(6aS-Trans)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide

(6aS-Trans)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide structure

CAS No.: 1227675-51-5

Chemical Name:: (6aS-Trans)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide

Synonyms: SCH 39166 HYDROBROMIDE;(6aS-Trans)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide

CBNumber:: CB5828599

Molecular Formula:: C19H21BrClNO

Molecular Weight:: 394.74

MDL Number:: MFCD08703109

MOL File:: Mol file

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:53:42

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(6aS-Trans)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide Properties

storage temp.	Desiccate at RT
solubility	DMSO: Slightly Soluble; Methanol: Slightly Soluble; Water: Slightly Soluble
form	A solid
Stability	Hygroscopic

(6aS-Trans)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML2591	SCH-39166 hydrobromide ≥98% (HPLC)	2587360-22-1	5 mg	$126	2025-07-31	Buy
Sigma-Aldrich	SML2591	SCH-39166 hydrobromide ≥98% (HPLC)	2587360-22-1	25 mg	$509	2025-07-31	Buy
Sigma-Aldrich	SML2591	SCH-39166 hydrobromide ≥98% (HPLC)	1227675-51-5	5MG	$123	2024-03-01	Buy
Sigma-Aldrich	SML2591	SCH-39166 hydrobromide ≥98% (HPLC)	1227675-51-5	25MG	$495	2024-03-01	Buy
Cayman Chemical	25331	SCH 39166 (hydrobromide) ≥98%	1227675-51-5	1mg	$44	2026-04-30	Buy

Product number	Packaging	Price	Buy
SML2591	5 mg	$126	Buy
SML2591	25 mg	$509	Buy
SML2591	5MG	$123	Buy
SML2591	25MG	$495	Buy
25331	1mg	$44	Buy

(6aS-Trans)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide Chemical Properties, Uses, Production

Description

SCH 39166 is a dopamine D₁ receptor antagonist (K_i = 5 nM). It is selective for D₁ over D_2-4 receptors (K_is = 3,751, >1,000, and 5,934 nM, respectively), however, it also binds to D₅ receptors (K_i = 4.4 nM). SCH 39166 inhibits food intake in a dose-dependent manner in rats (ED₅₀ = 0.84 mg/kg). It reduces ethanol intake in Sardinian alcohol-preferring rats and sucrose intake in water-deprived and water-sated rats without affecting food or total fluid intake. SCH 39166 also suppresses cocaine-induced arrhythmias in anesthetized dogs.

Uses

SCH 39166 is a dopamine D1/D5 receptor antagonist used in the treatment of schizophrenia, cocaine addiction and obesity.

storage

Desiccate at RT

References

[1] M.A.B. TICE. Characterization of the binding of SCH 39166 to the five cloned dopamine receptor subtypes[J]. Pharmacology Biochemistry and Behavior, 1994, 49 3: Pages 567-571. DOI: 10.1016/0091-3057(94)90070-1
[2] P TERRY J L K. A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behavior by the D1 agonist SKF38393.[J]. Psychopharmacology, 1994, 113 3-4: 328-333. DOI: 10.1007/bf02245205
[3] I PANOCKA. Effects of the dopamine D1 receptor antagonist SCH 39166 on the ingestive behaviour of alcohol-preferring rats.[J]. Psychopharmacology, 1995, 120 2: 227-235. DOI: 10.1007/bf02246198
[4] P M KANANI. Acute deleterious effects of cocaine on cardiac conduction, hemodynamics, and ventricular fibrillation threshold: effects of interaction with a selective dopamine D1 antagonist SCH 39166.[J]. Journal of Cardiovascular Pharmacology, 1998, 32 1: 42-48. DOI: 10.1097/00005344-199807000-00007

(6aS-Trans)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

(6aS-Trans)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide Suppliers

Global Suppliers ( 20)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29985	65
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8435	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11123	58
Energy Chemical	400-0056266	marketing1@energy-chemical.com	China	44927	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8137	58
Aladdin Scientific		tp@aladdinsci.com	United States	54738	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +86-15355479329	market18@leapchem.com	China	43303	58

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
EMMX Biotechnology LLC	60
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Energy Chemical	58
MedBioPharmaceutical Technology Inc	58
Aladdin Scientific	58
HANGZHOU LEAP CHEM CO., LTD.	58

1227675-51-5 ((6aS-Trans)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide) Related Search:

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SCH 39166 HYDROBROMIDE (6aS-Trans)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide 1227675-51-5 C19H20ClNOHBr Dopamine receptor