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Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]-

Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- structure

CAS No.: 2414373-55-8

Chemical Name:: Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]-

Synonyms: CDK6/9-IN-1;Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]-

CBNumber:: CB58382297

Molecular Formula:: C22H25ClN8O

Molecular Weight:: 452.94

MDL Number:

MOL File:: 2414373-55-8.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:14

Request For Quotation

Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- Properties

Density	1.374±0.06 g/cm3(Predicted)
pka	14.70±0.70(Predicted)

Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0127988	CDK6/9-IN-1	2414373-55-8	100mg	$285	2021-12-16	Buy
ChemScene	CS-0127988	CDK6/9-IN-1	2414373-55-8	250mg	$480	2021-12-16	Buy
ChemScene	CS-0127988	CDK6/9-IN-1	2414373-55-8	1g	$855	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0127988	100mg	$285	Buy
CS-0127988	250mg	$480	Buy
CS-0127988	1g	$855	Buy

Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- Chemical Properties, Uses, Production

Uses

CDK6/9-IN-1 (compound 66) is an orally active active and dual CDK 6 and CDK 9 inhibitor, with IC50 values of 40.5 nM and 39.5 nM for CDK6 anmd CDK9, respectively[1].

in vivo

CDK6/9-IN-1 (compound 66) significantly inhibits tumor growth in an xenograft mouse model with no obvious toxicity, indicating the promising therapeutic potential of CDK6/9 dual inhibitors for cancer treatment^[1].

IC 50

CDK6: 40.5 nM (IC₅₀); CDK9: 39.5 nM (IC₅₀)

References

[1] Yang Wang, et al. Discovery and SARs of 5-Chloro- N4-phenyl- N2-(pyridin-2-yl)pyrimidine-2,4-diamine Derivatives as Oral Available and Dual CDK 6 and 9 Inhibitors With Potent Antitumor Activity. J Med Chem. 2020 Mar 26;63(6):3327-3347. DOI:10.1021/acs.jmedchem.9b02121

Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- Suppliers

Global Suppliers ( 5)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Beckham Medical Technology Co., Ltd	13816613772	huahero21@sina.com	China	2994	55
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
Jinan Jiuli Biotechnology Co. , Ltd.	15865264761	486064515@qq.com	China	5000	58
Shanghai Merlot Chemical Co., LTD	15821661757	226174156@qq.com	China	476	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
Shanghai Beckham Medical Technology Co., Ltd	55
BOC Sciences	58
Jinan Jiuli Biotechnology Co. , Ltd.	58
Shanghai Merlot Chemical Co., LTD	58
TargetMol Chemicals Inc.	58

2414373-55-8 (Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]-) Related Search:

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Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- CDK6/9-IN-1 2414373-55-8