(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid
- CAS No.
- 261904-39-6
- Chemical Name:
- (2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid
- Synonyms
- (R)-3-bromo-2-hydroxy-2-methylpropanoic acid;136665;Flutamide Impurity 11;(2R)-3-Bromo-2-hydroxy-2-methylpropionicaci;(R)-3-Bromo-2-hydroxy-2-methylpropionic Acid;(2R)-3-Bromo-2-hydroxy-2-methylpropionic acid;(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid;(R)-3-Bromo-2-hydroxy-2-methylpropionic Acid >Propanoic acid,3-bromo-2-hydroxy-2-methyl-, (2R);(R)-3-Bromo-2-hydroxy-2-methylpropionic Acid
- CBNumber:
- CB5875184
- Molecular Formula:
- C4H7BrO3
- Molecular Weight:
- 183
- MDL Number:
- MFCD09751022
- MOL File:
- 261904-39-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (R)-3-Bromo-2-hydroxy-2-methylpropionic Acid >98.0%(GC)(T) | B4819 | 1g | $81 |
| (R)-3-Bromo-2-hydroxy-2-methylpropionic Acid >98.0%(GC)(T) | B4819 | 5g | $274 |
| (2R)-3-Bromo-2-hydroxy-2-methylpropionicAcid | B683755 | 5g | $275 |
| (2R)-3-Bromo-2-hydroxy-2-methylpropionicAcid | B683755 | 25g | $745 |
| (2R)-3-Bromo-2-hydroxy-2-methylpropanoicacid 95% | OR927021 | 10g | $805 |
| Melting point | 113.0 to 117.0 °C |
|---|---|
| Boiling point | 294.5±25.0 °C(Predicted) |
| Density | 1.831±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol |
| form | Solid |
| pka | 3.39±0.16(Predicted) |
| color | Off-White |
| InChI | InChI=1S/C4H7BrO3/c1-4(8,2-5)3(6)7/h8H,2H2,1H3,(H,6,7)/t4-/m0/s1 |
| InChIKey | HBJAYXGUOOININ-BYPYZUCNSA-N |
| SMILES | C(O)(=O)[C@](O)(C)CBr |
(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4819 | (R)-3-Bromo-2-hydroxy-2-methylpropionic Acid >98.0%(GC)(T) | 261904-39-6 | 1g | $81 | 2025-07-31 | Buy |
| TCI Chemical | B4819 | (R)-3-Bromo-2-hydroxy-2-methylpropionic Acid >98.0%(GC)(T) | 261904-39-6 | 5g | $274 | 2025-07-31 | Buy |
| TRC | B683755 | (2R)-3-Bromo-2-hydroxy-2-methylpropionicAcid | 261904-39-6 | 5g | $275 | 2021-12-16 | Buy |
| TRC | B683755 | (2R)-3-Bromo-2-hydroxy-2-methylpropionicAcid | 261904-39-6 | 25g | $745 | 2021-12-16 | Buy |
| Apolloscientific | OR927021 | (2R)-3-Bromo-2-hydroxy-2-methylpropanoicacid 95% | 261904-39-6 | 10g | $805 | 2021-12-16 | Buy |
(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid Chemical Properties,Uses,Production
Uses
(2R)-3-Bromo-2-hydroxy-2-methylpropionic Acid is used as a reagent in the synthesis of [18F]-radiolabeled hydroxyflutamide derivatives as prostate cancer PET imaging agents.
Synthesis
106138-80-1
261904-39-6
General procedure for the synthesis of (R)-3-bromo-2-hydroxy-2-methylpropionic acid (R-131) from the compound (CAS: 106138-80-1): bromolactone R-130 (18.5 g, 71 mmol) was dissolved in 300 mL of 24% hydrobromic acid and heated to reflux for 1 hour. After completion of the reaction, the resulting solution was diluted with 200 mL of brine and extracted with ethyl acetate (100 mL × 4). The organic phases were combined and washed with saturated sodium bicarbonate solution (100 mL × 4). The aqueous phase was acidified to pH = 1 with concentrated hydrochloric acid and extracted again with ethyl acetate (100 mL × 4). The organic phases were combined, dried with anhydrous sodium sulfate, filtered through diatomaceous earth, and concentrated to dryness under reduced pressure. The product was recrystallized from toluene to give 10.2 g (86% yield) of the target compound as colorless crystals. Melting point: 107-109 °C (S-isomer, literature value: melting point 109-113 °C).1H NMR (300 MHz, DMSO-d6) δ 3.63 (d, J=10.1 Hz, 1H, CHHa), 3.52 (d, J=10.1 Hz, 1H, CHHb), 1.35 (s, 3H, Me).IR (KBr) 3434 (OH), 3300-2500 (COOH), 1730 (C=O), 1449, 1421, 1380, 1292, 1193, 1085 cm-1. [α]D26 +10.5° (c=2.6, MeOH). Calculated elemental analysis (C4H7BrO3): C 26.25, H 3.86; measured values: C 26.28, H 3.75.
References
[1] Patent: US2003/225040, 2003, A1. Location in patent: Page 16
[2] Patent: US2006/9488, 2006, A1. Location in patent: Page/Page column 52
[3] Patent: WO2007/27582, 2007, A2. Location in patent: Page/Page column 61
[4] Patent: WO2007/62230, 2007, A2. Location in patent: Page/Page column 149; 151
[5] Patent: WO2008/8433, 2008, A2. Location in patent: Page/Page column 123; 1/19; 3/19; 7/19
(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid Preparation Products And Raw materials
(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| RR Scientific LLC | +86-13917743231 | sales@rrscientific.com | United States | 878 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 | linda@zhongda-biotech.com | China | 193 | 58 |
| Hebei Junhua Import and Export Co., LTD | +85259680964 | junhua1@hb-junhua.com | China | 933 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
View Lastest Price from (2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-10-14 | (2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6
|
US $0.00 / kg | 1kg | 97% | 1000 | Hebei Junhua Import and Export Co., LTD | |
 |
2024-10-23 | (2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6
|
US $66.00-5500.00 / g | 1g | 99% | 100kg | Wuhan Cell Pharmaceutical Co., Ltd | |
 |
2023-11-09 | Propanoic acid,3-bromo-2-hydroxy-2-methyl-, (2R)-
261904-39-6
|
US $80.00 / g | 1g | 98% | 10tons | qingdao future trading Co., Ltd |
-
- (2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6
- US $0.00 / kg
- 97%
- Hebei Junhua Import and Export Co., LTD
-
- (2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6
- US $66.00-5500.00 / g
- 99%
- Wuhan Cell Pharmaceutical Co., Ltd
-
- Propanoic acid,3-bromo-2-hydroxy-2-methyl-, (2R)-
261904-39-6
- US $80.00 / g
- 98%
- qingdao future trading Co., Ltd
