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tetramisole

tetramisole Structure
tetramisole structure
CAS No.
5036-02-2
Chemical Name:
tetramisole
Synonyms
Tetramizole;DL-tetramisole;6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole;Imidazo2,1-bthiazole, 2,3,5,6-tetrahydro-6-phenyl-;(+-)-2,3,5,6-tetrahydro-6-phenylimidazo(2,1-b)thiazole;6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
CBNumber:
CB5875351
Molecular Formula:
C11H12N2S
Molecular Weight:
204.29
MDL Number:
MOL File:
5036-02-2.mol
MSDS File:
SDS
Last updated:2026-01-13 11:18:01
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tetramisole Properties

Melting point 87-89°
Boiling point 344.4±45.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO; Methanol
form Solid
pka 10.00±0.40(Predicted)
color White (powder)
InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2
InChIKey HLFSDGLLUJUHTE-UHFFFAOYSA-N
SMILES S1CCN2CC(C3=CC=CC=C3)N=C12
FDA UNII C8M7RFE4NO
EPA Substance Registry System Tetramisole (5036-02-2)

SAFETY

Risk and Safety Statements

TSCA  TSCA listed

tetramisole price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 39242 Tetramisole ≥98% 5036-02-2 1mg $81 2026-04-30 Buy
Cayman Chemical 39242 Tetramisole ≥98% 5036-02-2 5mg $240 2026-04-30 Buy
aablocks AA00DFPJ Tetramisole ≥98% 5036-02-2 1mg $81 2026-05-28 Buy
aablocks AA00DFPJ Tetramisole ≥98% 5036-02-2 5mg $240 2026-05-28 Buy
Crysdot CD43000325 6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole 95+% 5036-02-2 5g $671 2026-05-27 Buy
Product number Packaging Price Buy
39242 1mg $81 Buy
39242 5mg $240 Buy
AA00DFPJ 1mg $81 Buy
AA00DFPJ 5mg $240 Buy
CD43000325 5g $671 Buy

tetramisole Chemical Properties, Uses, Production

Uses

Tetramisol is an isolated intermediate in the synthesis of 4-Hydroxy-tetramisole (H595270), a metabolite of Tetramisole, an anthelmintic.

Definition

ChEBI: 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole is an imidazothiazole that is imidazo[2,1-b][1,3]thiazole in which the double bonds at the 2-3 and 5-6 positions have been reduced to single bonds and in which one of the hydrogens at position 6 is replaced by a phenyl group. It has a role as a xenobiotic and an environmental contaminant.

in vivo

Tetramisole (0.54 mg/kg; intravenous injection; single dose; 3 minutes pretreatment) significantly reduces the number and duration of ventricular arrhythmias and the incidence of ventricular fibrillation in the Sprague-Dawley rat model of myocardial infarction induced by coronary artery ligation, and this effect is reversed by the IK1 channel blocker chloroquine (CQ)[2].
Tetramisole (0.54 mg/kg; intraperitoneal injection; once a day; 10 days) improves cardiac contractile function, reduces cardiomyocyte hypertrophy and interstitial fibrosis, and inhibits the activation of the PKA signaling pathway in the Sprague-Dawley rat model of isoproterenol (Iso)-induced cardiac remodeling, and the effect is dependent on the IK1 channel activity[2].

Animal Model:Male Sprague-Dawley rats (2 months old, weight not specified) + coronary ligation-induced acute myocardial infarction model[2]
Dosage:0.18, 0.54, 1.8 mg/kg (dissolved in saline)
Administration:Intravenous injection 3 minutes before coronary artery occlusion; single dose
Result:Significantly reduced premature ventricular contractions (PVC) from 134 to 16 episodes, shortened ventricular tachycardia (VT) duration from 59.4 s to 8.1 s, and eliminated ventricular fibrillation (VF) (duration 0 s, incidence 0%), compared to control.
These anti-arrhythmic effects were largely reversed by co-administration of chloroquine (7.5 μg/kg), an IK1 antagonist. Pretreatment for 10 days (0.54 mg/kg/day) also reduced VT duration (42.7 s to 6.5 s) and abolished VF, associated with upregulated Kir2.1 protein expression in ventricular tissue.
Animal Model:Male Sprague-Dawley rats (2 months old, weight not specified) + isoproterenol (3 mg/kg/day, i.p., 10 days)-induced cardiac remodeling model[2]
Dosage:0.54 mg/kg/day (dissolved in saline)
Administration:Intraperitoneal injection once daily for 10 days
Result:Prevented Iso-induced increases in interventricular septum thickness and left ventricular wall thickness, normalized left ventricular ejection fraction (EF) and fractional shortening (FS), and reduced myocardial cell cross-sectional area by 22% compared to Iso group.
Masson's trichrome staining showed a 35% reduction in interstitial fibrosis, accompanied by downregulated phosphorylated PKA (p-PKA) and upregulated Kir2.1/SAP97 signaling.
Co-administration of chloroquine abolished these protective effects, confirming dependence on IK1 channel activation.

tetramisole synthesis

3882-98-2
93-52-7
5036-02-2
Synthesis of tetramisole from 2-Amino-2-thiazoline hydrochloride and (1,2-Dibromoethyl)benzene

tetramisole Preparation Products And Raw materials

Raw materials

2-Amino-2-thiazoline hydrochloride (1,2-Dibromoethyl)benzene

Preparation Products

Tetramisole hydrochloride

tetramisole Suppliers

Global Suppliers ( 29)
Supplier Tel Email Country ProdList Advantage
Zhengzhou Huiju Chemical Co., Ltd. 0371-55900031 18137872243 3927209986@qq.com China 9999 55
Aikon International Limited 025-58859352 19370895928 sales01@aikonchem.com China 15078 58
CD Chemical Group Limited +86-13651442114 info@codchem.com China 17253 58
Shijiazhuang Tongyang Import and Export Co., LTD admin@sjztongyang.com China 971 58
Dayang Chem (Hangzhou) Co.,Ltd. +86-0571-88938639 17705817739 info@dycnchem.com China 52451 58
Hebei ruqi technology co., ltd 176-03256889 17603256889 1123722730@qq.com China 3354 58
Hebei Fanggan New Material Technology Co., LTD 86-180-3439-5858-5858 18034395858 China 1048 58
Huayin Sample Biological Technology Co. LTD 13892502238 1453186328@qq.com China 929 58
Shandong Liteng Biotechnology Co., Ltd 15020019777 18663721413 rosy@litengpharm.com China 1615 58
Shandong Liteng Biotechnology Co. , Ltd. +86-18663721413 +86-15552573001 rosy@litengpharm.com China 3279 58
Supplier Advantage
Zhengzhou Huiju Chemical Co., Ltd. 55
Aikon International Limited 58
CD Chemical Group Limited 58
Shijiazhuang Tongyang Import and Export Co., LTD 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
Hebei ruqi technology co., ltd 58
Hebei Fanggan New Material Technology Co., LTD 58
Huayin Sample Biological Technology Co. LTD 58
Shandong Liteng Biotechnology Co., Ltd 58
Shandong Liteng Biotechnology Co. , Ltd. 58

View Latest Price from tetramisole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tetramisole pictures 2026-07-07 Tetramisole
5036-02-2
 $1.00 10kg 99% 1000 ARCTIC EXPORTS INC
tetramisole pictures 2021-08-10 tetramisole
5036-02-2
 $70.00 2KG 99% Shijiazhuang tongyang Import and Export Co., LTD
  • tetramisole pictures
  • tetramisole
    5036-02-2
  • $70.00
  • 99%
  • Shijiazhuang tongyang Import and Export Co., LTD

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(+-)-2,3,5,6-tetrahydro-6-phenylimidazo(2,1-b)thiazole Imidazo2,1-bthiazole, 2,3,5,6-tetrahydro-6-phenyl- 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole DL-tetramisole Tetramizole 5036-02-2 C11H12N2S