cyclobutyrol
- CAS No.
- 512-16-3
- Chemical Name:
- cyclobutyrol
- Synonyms
- Tribil;JL 130;Bilimix;Hebucol;Epatodin;Epadomus;Hebulina;BRN2209058;BRN 2209058;BRN-2209058
- CBNumber:
- CB5934780
- Molecular Formula:
- C10H18O3
- Molecular Weight:
- 186.249
- MDL Number:
- MFCD00129943
- MOL File:
- 512-16-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 81-82° |
|---|---|
| Boiling point | bp24 164°; bp16 167-170° |
| Density | d418.8 1.0010 |
| refractive index | nD18.8 1.4680 (Kon, Naravanan, loc. cit.) |
| pka | 4.69±0.10(Predicted) |
| FDA UNII | 8T4L120N6M |
| ATC code | A05AX03 |
| EPA Substance Registry System | Cyclobutyrol (512-16-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
| TSCA | TSCA listed |
| Toxicity | LD50 oral in rat: 4820mg/kg |
cyclobutyrol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | AAA51216 | 2-(1-Hydroxycyclohexyl)butanoic acid | 512-16-3 | 50mg | $545 | 2026-06-04 | Buy |
| Biosynth | AAA51216 | 2-(1-Hydroxycyclohexyl)butanoic acid | 512-16-3 | 0.5g | $1675 | 2026-06-04 | Buy |
| ChemScene | CS-0066299 | Cyclobutyrol ≥98% | 512-16-3 | 100mg | $408 | 2026-06-04 | Buy |
| ChemScene | CS-0066299 | Cyclobutyrol ≥98% | 512-16-3 | 250mg | $581 | 2026-06-04 | Buy |
| ChemScene | CS-0066299 | Cyclobutyrol ≥98% | 512-16-3 | 500mg | $917 | 2026-06-04 | Buy |
cyclobutyrol Chemical Properties, Uses, Production
Originator
Hebucol,Logeais,France,1957
Definition
ChEBI: A hydroxy monocarboxylic acid in which the hydroxy group is geminal to a 1-carboxypropyl group on a cyclohexane ring.
Manufacturing Process
Into a balloon flask with two lateral necks furnished with an efficient
mechanical agitator and protected from moisture by a calcium chloride guard,
there are introduced 12 g (0.185 mol) of pure powdered zinc and 20 ml of a
solution of 16.6 g (0.17 mol) of anhydrous cyclohexanone and 31.5 g (0.16
mol) of ethyl α-bromobutyrate in 25 ml of anhydrous benzene. With vigorous
stirring in a manner to put the zinc into suspension, the balloon flask is
gradually heated in an oil bath to 100°C to 105°C. After a few minutes, a
reaction starts, causing violent boiling which is maintained while adding the
balance of the reactants. Boiling is then continued for one hour. After cooling,
the reaction mixture is turned into a beaker containing 30 ml of sulfuric acid
to half (by volume) with ice. After agitation, the mixture is decanted into a
container for separation. The aqueous phase is reextracted with benzene. The
pooled benzene solutions are washed with dilute (10%) cold sulfuric acid, then
with cold sodium carbonate (5%) and then with ice water, and dried over
anhydrous sodium sulfate. The benzene is evaporated and the ester, which is
ethyl α(hydroxy-1-cyclohexyl) butyrate, is distilled off under reduced pressure.
The yield obtained was 17 to 19 g or 49% to 55%.
The ester was saponified with baryta in aqueous methanol as follows:
21.5 g (0.1 mol) of the above ethyl ester is saponified by boiling under reflux
for 4 hours, while agitating, with 30 g (0.095 mol) of barium oxide hydrated
to 8H2O in 250 ml of a mixture of equal volumes of methanol and water. After
concentration to one-half its volume under reduced pressure and filtration, the
aqueous solution is washed with ether and then acidified at 0°C with 10%
hydrochloric acid. The acid liberated in oily form is extracted with ether. The
ether is washed with water, dried and evaporated. The yield is 75-80% (14-15
g of crude acid) which crystallizes spontaneously little by little. It can be
crystallized in a mixture of ether and petroleum ether (1:10) or, with better
yield, in light gasoline or oil (solubility of the pure acid ranges from 0.3% at
0°C to 100% at the boiling point). The yield of crystals is 75-80%. The
α(hydroxy-1-cyclohexyl) butyric acid thus obtained is a colorless crystalline
product with a melting point of 81°C to 82°C.
Therapeutic Function
Choleretic
cyclobutyrol Preparation Products And Raw materials
Raw materials
Preparation Products
cyclobutyrol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Block Chemical Technology (Shanghai) Co., LTD | 021-20432219 13918097649 | li_jinfei@acblock-lab.com | China | 9964 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53736 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Block Chemical Technology (Shanghai) Co., LTD | 58 |
| TargetMol Chemicals Inc. | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from cyclobutyrol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Cyclobutyrol
512-16-3
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- Cyclobutyrol
512-16-3
- $1520.00-2500.00
- TargetMol Chemicals Inc.
