GW 3965 hydrochloride
- CAS No.
- 405911-17-3
- Chemical Name:
- GW 3965 hydrochloride
- Synonyms
- CS-742;GW3965 HCl;GW3965 HCl Salt;GW3965 HCl ，S2630;W 3965 HYDROCHLORIDE;GW3965 hydrochloride, >=98%;GW-3965 hydrochloride GW3965;GW 3965 hydrochloride, LXR agonist;GW3965 hydrochloride, 10 mM in DMSO;GW 3965 HYDROCHLORIDE; GW-3965 HYDROCHLORIDE;
- CBNumber:
- CB5972490
- Molecular Formula:
- C33H31ClF3NO3.HCl
- Molecular Weight:
- 0
- MDL Number:
- MFCD08276920
- MOL File:
- 405911-17-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318-H413 | |||||||||
| Precautionary statements | P264-P270-P273-P280-P301+P312-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 4 Eye Dam. 1 |
|||||||||
| NFPA 704 |
|
GW 3965 hydrochloride price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G6295 | GW3965 hydrochloride ≥98% (HPLC), powder | 405911-17-3 | 5mg | $227 | 2026-04-30 | Buy |
| Sigma-Aldrich | G6295 | GW3965 hydrochloride ≥98% (HPLC), powder | 405911-17-3 | 25mg | $774 | 2026-04-30 | Buy |
| TCI Chemical | G0655 | GW3965 Hydrochloride | 405911-17-3 | 10MG | $129 | 2026-04-30 | Buy |
| TCI Chemical | G0655 | GW3965 Hydrochloride | 405911-17-3 | 50MG | $429 | 2026-04-30 | Buy |
| Cayman Chemical | 10054 | GW 3965 (hydrochloride) ≥98% | 405911-17-3 | 1mg | $28 | 2026-04-30 | Buy |
GW 3965 hydrochloride Chemical Properties, Uses, Production
Uses
GW3965 Hydrochloride, is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.
Biochem/physiol Actions
GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.
in vivo
GW3965 hydrochloride induces an increase of neuroactive steroids in the spinal cord, the cerebellum and the cerebral cortex of STZ-rats, but not in the CNS of non-pathological animals. GW3965 hydrochloride treatment induces an increase of dihydroprogesterone in the spinal cord of diabetic animals in association with an increase of myelin basic protein expression[1]. GW3965 hydrochloride (40 mg/kg, p.o.) strongly induces ABCA1 expression and reduces LDLR expression, and this is accompanied by 59% inhibition of tumor growth, and a 25-fold increase in GBM cell apoptosis in vivo[2]. GW3965 hydrochloride (2 mg/kg, i.v.) increases bleeding time and modulated platelet thrombus formation in vivo[3].
storage
Desiccate at RT
GW 3965 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2282 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from GW 3965 hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-30 | GW3965 hydrochloride
405911-17-3
|
$35.00-90.00 | 99.03% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-04 | GW3965 HCl
405911-17-3
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2020-01-09 | GW 3965 HYDROCHLORIDE
405911-17-3
|
$1.00 | 1KG | 85.0-99.8% | 20tons | Career Henan Chemical Co |
-
- GW3965 hydrochloride
405911-17-3
- $35.00-90.00
- 99.03%
- TargetMol Chemicals Inc.
-
- GW3965 HCl
405911-17-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- GW 3965 HYDROCHLORIDE
405911-17-3
- $1.00
- 85.0-99.8%
- Career Henan Chemical Co
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