Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>AS 604850

AS 604850

AS 604850 Structure
AS 604850 structure
CAS No.
648449-76-7
Chemical Name:
AS 604850
Synonyms
CS-538;AS 604850;AS-604850;AS 604850;AS 604850 USP/EP/BP;PI 3-Kγ Inhibitor II;PI 3-Kγ Inhibitor II;AS-604850, 10 mM in DMSO;AS604850; AS 604850; AS-604850;PI 3-Kinase Inhibitor (AS604850);PI 3-Kinase Inhibitor (AS604850) B-0302
CBNumber:
CB5972768
Molecular Formula:
C11H5F2NO4S
Molecular Weight:
285.22
MDL Number:
MFCD09265247
MOL File:
648449-76-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
AS 604850 ≥98% (HPLC), solid A0231 5mg $161
PI 3-Kγ Inhibitor II 528108 5mg $300
AS-604850 ≥98% 10010175 1mg $29
AS-604850 ≥98% 10010175 5mg $123
AS-604850 ≥98% 10010175 10mg $215
More product size
Request For Quotation

AS 604850 Properties

Density 1.71
storage temp. 2-8°C
solubility DMSO: >10mg/mL
form solid
pka 7.07±0.20(Predicted)
color off-white
InChI 1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4-
InChIKey SRLVNYDXMUGOFI-YWEYNIOJSA-N
SMILES FC1(F)Oc2ccc(cc2O1)\C=C3/SC(=O)NC3=O
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H317
Precautionary statements  P280
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xi
Risk Statements  43
Safety Statements  36/37
WGK Germany  3
Storage Class 11 - Combustible Solids

AS 604850 price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A0231 AS 604850 ≥98% (HPLC), solid 648449-76-7 5mg $161 2026-04-30 Buy
Sigma-Aldrich 528108 PI 3-Kγ Inhibitor II 648449-76-7 5mg $300 2026-04-30 Buy
Cayman Chemical 10010175 AS-604850 ≥98% 648449-76-7 1mg $29 2026-04-30 Buy
Cayman Chemical 10010175 AS-604850 ≥98% 648449-76-7 5mg $123 2026-04-30 Buy
Cayman Chemical 10010175 AS-604850 ≥98% 648449-76-7 10mg $215 2026-04-30 Buy
Product number Packaging Price Buy
A0231 5mg $161 Buy
528108 5mg $300 Buy
10010175 1mg $29 Buy
10010175 5mg $123 Buy
10010175 10mg $215 Buy

AS 604850 Chemical Properties,Uses,Production

Description

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of PI at the three position of the inositol ring to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kγ is a class 1B PI3K that is composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit, whereas PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits. AS-604850 is a selective, ATP-competitive inhibitor of PI3Kγ with IC50 values of 0.25, >20, >20, and 4.5 μM for the human recombinant γ, δ, β, and α isoforms, respectively. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 μM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

Uses

AS-604850 is a selective and ATP-competitive phosphoinositide 3-kinase gamma (PI3Kγ) inhibitor.

in vivo

AS-604850 (10-100 mg/kg; oral administration; for 4.5 or 4.25 hours; Balb/C or C3H mice) treatment reduces RANTES-induced peritoneal neutrophil recruitment with an ED50 value of 42.4 mg/kg. In the thioglycollate-induced peritonitis model, oral administration of 10 mg/kg AS-604850 results in a 31% reduction of neutrophil recruitment[1].

Animal Model:Balb/C or C3H mice with human recombinant RANTES or thioglycollate[1]
Dosage:10 mg/kg, 30 mg/kg or 100 mg/kg
Administration:Oral administration; for 4.5 or 4.25 hours
Result:Reduced RANTES-induced peritoneal neutrophil recruitment with an ED50 value of 42.4 mg/kg. In the thioglycollate-induced peritonitis model, resulted in a 31% reduction of neutrophil recruitment.

IC 50

PI3Kγ: 0.25 μM (IC50); PI3Kγ: 0.18 μM (Ki); PI3Kα: 4.5 μM (IC50)

References

1. camps m, rückle t, ji h et al. blockade of pi3k-gamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. nat med. 2005 sep;11(9):936-43.2. hohenester s, gates a, wimmer r et al. phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. j hepatol. 2010 nov;53(5):918-26.

AS 604850 Preparation Products And Raw materials

Raw materials

Preparation Products

AS 604850 Suppliers

Global( 133)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32998 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 contact@trustwe.com China 5742 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 		+86-86-22-87899925 +86-8618522618860 18522618860@163.com China 694 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1059@dideu.com China 29096 58
BOC Sciences 		16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10378 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
Nantong HI-FUTURE Biology Co., Ltd. 		+86-18051384581 sales@chemhifuture.com China 3123 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
BOC Sciences 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58

View Lastest Price from AS 604850 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AS-604850 pictures 2026-07-27 AS-604850
648449-76-7
 $43.00-119.00 99.84% 10g TargetMol Chemicals Inc.
AS 604850 pictures 2019-07-10 AS 604850
648449-76-7
 $7.00 1KG 99% 1000KG Career Henan Chemical Co
  • AS-604850 pictures
  • AS-604850
    648449-76-7
  • $43.00-119.00
  • 99.84%
  • TargetMol Chemicals Inc.
  • AS 604850 pictures
  • AS 604850
    648449-76-7
  • $7.00
  • 99%
  • Career Henan Chemical Co

AS 604850 Spectrum

AS 604850(648449-76-7)1HNMR

648449-76-7(AS 604850)Related Search:

Thianaphthene DIBENZAZEPINE Dibenzothiophene PD 173074 Selumetinib
Nintedanib PHT-427 OSU-03012 (AR-12) AT9283

1of2

AS 604850 PI3Kγ inhibitor, 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione PI 3-Kinase Inhibitor (AS604850) B-0302 (Z)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione AS-604850;AS 604850 PI 3-Kγ Inhibitor II 5-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylene]thiazolidine-2,4-dione PI 3-Kinase Inhibitor (AS604850) CS-538 AS604850; AS 604850; AS-604850 PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem 2,4-Thiazolidinedione, 5-[(2,2-difluoro-1,3-benzodioxol-5-yl)methylene]- AS 604850 USP/EP/BP PI 3-Kγ Inhibitor II AS-604850 AS604850 5-((2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione AS-604850, ATP-competitive PI3Kgamma inhibitor AS-604850, 10 mM in DMSO PI 3-Kγ Inhibitor II 5-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylene]-2,4-thiazolidinedione 648449-76-7 C11H5F2NO4S Akt mTOR PI3K Inhibitors