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OSu-03012

OSu-03012 Structure
OSu-03012 structure
CAS No.
742112-33-0
Chemical Name:
OSu-03012
Synonyms
AR-12;CS-1848;N/AAR-12;OSu-03012;OSU-03012, >=98%;OSU-03012 (AR-12);OSU-03012 USP/EP/BP;PDK1 inhibitor AR-12;Osu03012, 10 mM in DMSO;OSU-03012 (AR-12) ，S1106
CBNumber:
CB22501006
Molecular Formula:
C26H19F3N4O
Molecular Weight:
460.45
MDL Number:
MFCD12912272
MOL File:
742112-33-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:50:35
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OSu-03012 Properties

storage temp. Store at -20°C
solubility ≥23 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form solid
color White to off-white
CAS DataBase Reference 742112-33-0
FDA UNII EX3O2Q61UV

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501

OSu-03012 price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10008005 OSU03012 ≥98% 742112-33-0 5mg $81 2026-04-30 Buy
Cayman Chemical 10008005 OSU03012 ≥98% 742112-33-0 10mg $128 2026-04-30 Buy
Cayman Chemical 10008005 OSU03012 ≥98% 742112-33-0 50mg $553 2026-04-30 Buy
Cayman Chemical 10008005 OSU03012 ≥98% 742112-33-0 100mg $868 2026-04-30 Buy
ChemScene CS-0151 OSU-03012 98.67% 742112-33-0 5mg $65 2026-06-04 Buy
Product number Packaging Price Buy
10008005 5mg $81 Buy
10008005 10mg $128 Buy
10008005 50mg $553 Buy
10008005 100mg $868 Buy
CS-0151 5mg $65 Buy

OSu-03012 Chemical Properties, Uses, Production

Description

Cyclooxygenase-2 (COX-2) appears to play a significant role in the development and progression of cancer and COX-2 inhibitors such as celecoxib exhibit anti-cancer activity. OSU03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway. It has an IC50 value of 5 μM for inhibition of 3-phosphoinositide-dependent kinase-1, and therefore Akt activation, with no measurable COX-2 inhibition up to 50 μM. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 μM across a panel of 60 cancer cell lines. It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway. OSU03012 induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.

Uses

OSU 03012 is a PDK1 inhibitor and inducer of caspase and p53-independent apoptosis, also used in the development of anticancer agents by modification of novel immunosuppressant FTY720 and PDK1 inhibitor OSU-03012, compound for treating Alzheimers diseases.

Definition

ChEBI: A member of the class of pyrazoles that is N-[4-(pyrazol-1-yl)phenyl]glycinamide in which the pyrazole ring is substituted at positions 3 and 5 by trifluoromethyl and phenanthrene-2-yl groups respectively.

storage

Store at -20°C

References

[1] zhu j1, huang jw, tseng ph, yang yt, fowble j, shiau cw, shaw yj, kulp sk, chen cs. from the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. cancer res. 2004 jun 15;64(12):4309-18.
[2] lee tx1, packer md, huang j, akhmametyeva em, kulp sk, chen cs, giovannini m, jacob a, welling db, chang ls. growth inhibitory and anti-tumour activities of osu-03012, a novel pdk-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. eur j cancer. 2009 jun;45(9):1709-20.

OSu-03012 Preparation Products And Raw materials

Raw materials

Preparation Products

OSu-03012 Suppliers

Global Suppliers ( 169)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Shanghai civi chemical technology co.,Ltd 86-21-34053660 sale@labgogo.com China 9853 52
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60
VDM Biochemicals 64
Jinan Trio PharmaTech Co., Ltd. 62
Dalian Meilun Biotech Co., Ltd. 58
Shanghai civi chemical technology co.,Ltd 52
NCE Biomedical Co.,Ltd. 55
Shanghai T&W Pharmaceutical Co., Ltd. 58
Nanjing Norris-Pharm Technology Co., Ltd 55

View Latest Price from OSu-03012 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Osu03012 pictures 2026-08-20 Osu03012
742112-33-0
 $31.00-79.00 97.95% 10g TargetMol Chemicals Inc.
OSU-03012 pictures 2019-07-06 OSU-03012
742112-33-0
 $2.00 1kg 99% 100kg Career Henan Chemical Co
  • Osu03012 pictures
  • Osu03012
    742112-33-0
  • $31.00-79.00
  • 97.95%
  • TargetMol Chemicals Inc.
  • OSU-03012 pictures
  • OSU-03012
    742112-33-0
  • $2.00
  • 99%
  • Career Henan Chemical Co

OSu-03012 Spectrum

OSU-03012(742112-33-0)1HNMR

742112-33-0 (OSu-03012) Related Search:

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1of3

OSU-03012, >=98% OSU-03012 (AR-12) AR-12 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide OSU-03012 N/AAR-12 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide OSU-03012 (AR-12);N/AAR-12; OSU03012; OSU 03012 CS-1848 N/AAR-12; OSU03012; OSU 03012 Acetamide, 2-amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]- OSU-03012 USP/EP/BP Osu-03012|||Osu 03012|||AR-12 PDK1 inhibitor AR-12 Osu03012, 10 mM in DMSO OSU-03012 (AR-12) ，S1106 OSU-03012 (Synonyms: AR-12 OSu-03012 742112-33-0 C26H19F3N4O Inhibitors Inhibitor of phosphoinositide-dependent kinase-1. Akt mTOR PI3K