ChemicalBook >> CAS DataBase List >>1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one structure

CAS No.: 24310-36-9

Chemical Name:: 1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

Synonyms: Tolvaptan Impurity 132;1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROB;1,2,3,4-tetrahydro-1-tosylbenzo[b]azepin-5-one;1-Tosyl-2,3-dihydro-1H-1-benzazepine-5(4H)-one;1-Tosyl-2,3,4,5-tetrahydro-1H-1-benzazepine-5-one;1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;1-(4-methylphenyl)sulfonyl-3,4-dihydro-2H-1-benzazepin-5-one;1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one;1,2,3,4-tetrahydro-1-(4-methylbenzenesulfonyl)-1-benzazepin-...;1,2,3,4-tetrahydro-1-(4-Methylbenzenesulfonyl)-1-benzazepin-5-one

CBNumber:: CB6119799

Molecular Formula:: C17H17NO3S

Molecular Weight:: 315.39

MDL Number:: MFCD00795994

MOL File:: 24310-36-9.mol

Last updated:2026-09-12 18:53:45

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1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one Properties

Melting point	126 °C(Solv: methanol (67-56-1))
Boiling point	489.7±48.0 °C(Predicted)
Density	1.286±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	-3+-.0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319
Precautionary statements	P305+P351+P338
HazardClass	IRRITANT

1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	R238716	1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDRO-BENZO(B)AZEPIN-5-ONE Aldrich^CPR	24310-36-9	1 unit	$32.7	2026-04-30	Buy
Sigma-Aldrich	R238716	1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDRO-BENZO(B)AZEPIN-5-ONE Aldrich	24310-36-9	25mg	$29.8	2024-03-01	Buy
Usbiological	410819	1,2,3,4-Tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one	24310-36-9	25mg	$319	2026-06-03	Buy
Usbiological	410819	1,2,3,4-Tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one	24310-36-9	100mg	$418	2026-06-03	Buy
Biosynth	FT151126	1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one	24310-36-9	5g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
R238716	1 unit	$32.7	Buy
R238716	25mg	$29.8	Buy
410819	25mg	$319	Buy
410819	100mg	$418	Buy
FT151126	5g	$900	Buy

1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one Chemical Properties, Uses, Production

Uses

1,2,3,4-Tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one is an intermediate used to prepare nonpeptide vasopressin V2 receptor antagonist tetrahydro-1H-benzazepines. It is also used to synthesize 4''-[(4,4-difluoro-5-methylidene-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl)carbonyl]-2-phenylbenzanilide derivatives as non-peptide arginine vasopressin antagonists for both V1A and V2 receptors.

Synthesis

1127-74-8

98-59-9

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE

24310-36-9

To a stirred solution of 1,2,3,4-tetrahydrobenzo[b]azepin-5-one (50 g, 0.31 mol) in dichloromethane (DCM, 250 mL) was added pyridine (175 mL). The reaction mixture was cooled in an ice bath, followed by the slow addition of p-toluenesulfonyl chloride (TsCl, 84 g, 0.44 mol). When the addition was complete, the mixture was gradually warmed to room temperature and stirred continuously overnight. Upon completion of the reaction, the mixture was diluted with water (750 mL) and subsequently extracted with dichloromethane (300 mL x 3). The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. The resulting residue was washed with mixed solvents (petroleum ether/ethyl acetate = 70:1) to afford the target product 1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one as a light yellow solid (97 g, 99% yield). eSI MS m/z = 316.05 [M + H]+.

References

[1] Patent: WO2017/123884, 2017, A1. Location in patent: Page/Page column 92
[2] Heterocycles, 2000, vol. 52, # 1, p. 81 - 84
[3] Patent: WO2005/37796, 2005, A1. Location in patent: Page/Page column 160
[4] Patent: US2015/291533, 2015, A1. Location in patent: Paragraph 0137-0139

1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one Preparation Products And Raw materials

Raw materials

Butanoic acid, 4-[[(4-methylphenyl)sulfonyl]phenylamino]- 1H-1-Benzazepine-4-carboxylic acid, 2,3,4,5-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5-oxo-, methyl ester 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Tosyl chloride 5-Oxo-1-(4-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester

Pyridine Dichloromethane

1of2

Preparation Products

5H-1-Benzazepin-5-one, 4,4-difluoro-1,2,3,4-tetrahydro-

1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one Suppliers

Global Suppliers ( 84)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6740	52
Shanghai Ennopharm Co., Ltd.	+86 (21) 6435-5022		China	4263	65
Suzhou Sibian Chemical Technology Co.,Ltd.	0512-65617459 18915409046	sales@sibian-chem.com	China	1917	55
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12323	58
China Nobel Chem Co., Limited	+86(0)21 60484900		China	762	50
Shanghai JONLN Reagent Co., Ltd.	400-0066400 13621662912	422131432@qq.com	China	9970	55
Taizhou Tongxin Bio-Tech Co., Ltd	0523-86818997 18652728585	sales@allyrise.com	China	2987	60
Shanghai HuanChuan Industry Co.,Ltd.	021-61478794	sales@hcshhai.com	China	9781	50

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Shanghai Longsheng chemical Co.,Ltd.	59
XiaoGan ShenYuan ChemPharm co,ltd	52
Shanghai Ennopharm Co., Ltd.	65
Suzhou Sibian Chemical Technology Co.,Ltd.	55
Beijing HuaMeiHuLiBiological Chemical	58
China Nobel Chem Co., Limited	50
Shanghai JONLN Reagent Co., Ltd.	55
Taizhou Tongxin Bio-Tech Co., Ltd	60
Shanghai HuanChuan Industry Co.,Ltd.	50

View Latest Price from 1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-18	1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE 24310-36-9		1G	98.0%	2000	Shenzhen Nexcon Pharmatechs Ltd.
	2019-07-06	1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE 24310-36-9	$3.00	1KG	99%	100kg	Career Henan Chemical Co

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE
24310-36-9
98.0%
Shenzhen Nexcon Pharmatechs Ltd.

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE
24310-36-9
$3.00
99%
Career Henan Chemical Co

24310-36-9 (1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one) Related Search:

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2,3,4,5-Tetrahydro-1H-benzo[b]azepine

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