Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>1,2,3,4-Tetrahydro-benzo[b]azepin-5-one

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Structure
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one structure
CAS No.
1127-74-8
Chemical Name:
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
Synonyms
1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;1,2,3,4-Tetrahydro-1-benzazepin-5-one;Tovaptan impurity 13;1,2,3,4-Tetrahydrobenzoazepine-5-one;5-oxo-2,3,4,5-tetrahydro-1H-benzazepine;1,2,3,4-tetrahydrobenzo[b]azepin-5-tone;1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE;3,4-dihydro-1H-benzo[b]azepin-5(2H)-one;2,3,4,5-tetrahydro-1H-1-benzazepin-5-one;1,2,3,4-Tetrahydro-5H-1-benzazepin-5-one
CBNumber:
CB2357010
Molecular Formula:
C10H11NO
Molecular Weight:
161.2
MDL Number:
MFCD03426404
MOL File:
1127-74-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-05 19:35:02
Request For Quotation

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Properties

Boiling point 314.6±12.0 °C(Predicted)
Density 1.100±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka 3.05±0.20(Predicted)
form Powder
color White to light green
InChI InChI=1S/C10H11NO/c12-10-6-3-7-11-9-5-2-1-4-8(9)10/h1-2,4-5,11H,3,6-7H2
InChIKey NKRKBYFBKLDCFB-UHFFFAOYSA-N
SMILES N1C2=CC=CC=C2C(=O)CCC1
CAS DataBase Reference 1127-74-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H332-H335-H312-H319-H302
Precautionary statements  P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P261-P271-P304+P340-P312
HazardClass  IRRITANT
HS Code  2933998090

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AstaTech 59670 1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 98% 1127-74-8 5G $34 2026-04-30 Buy
AstaTech 59670 1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 98% 1127-74-8 25G $111 2026-04-30 Buy
Apolloscientific OR315598 3,4-Dihydro-1H-benzo[b]azepin-5(2H)-one >98% 1127-74-8 1g $21 2026-06-04 Buy
Apolloscientific OR315598 3,4-Dihydro-1H-benzo[b]azepin-5(2H)-one >98% 1127-74-8 5g $35 2026-06-04 Buy
Apolloscientific OR315598 3,4-Dihydro-1H-benzo[b]azepin-5(2H)-one >98% 1127-74-8 25g $166 2026-06-04 Buy
Product number Packaging Price Buy
59670 5G $34 Buy
59670 25G $111 Buy
OR315598 1g $21 Buy
OR315598 5g $35 Buy
OR315598 25g $166 Buy

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Chemical Properties, Uses, Production

Synthesis

Polyphosphoric acid (25g) was heated at 100°C under nitrogen until it could be stirred. 1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydro-benzo[b]azepin-5-one (2.6g, 8.2 6mmol) was added portion-wise and the reaction mixture was heated at 100°C for 1.5h. It was poured into ice and basified with 2M NaOH(aq). The aqueous layer was extracted twice with dichloromethane. The organic extracts were combined, washed with brine, dried and reduced in vacuo. The residue was purified by flash chromatography on silica gel (eluant; 40percent EtOAc: 60percent hexane) to yield 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one (1.05g, 79percent).

References

[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 19, p. 8670 - 8692
[2] Patent: WO2006/21213, 2006, A2. Location in patent: Page/Page column 34
[3] Patent: WO2005/37796, 2005, A1. Location in patent: Page/Page column 39
[4] Journal of Organic Chemistry, 2016, vol. 81, # 8, p. 3136 - 3148

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Preparation Products And Raw materials

Raw materials

1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

Preparation Products

2,3,4,5-Tetrahydro-1H-benzo[b]azepine

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Suppliers

Global Suppliers ( 209)
Supplier Tel Email Country ProdList Advantage
Jiangxi Jinfeng Pharmaceutical Co., Ltd 793-5181188 18170363299 yangyuening@jxjfpharma.com China 62 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Supplier Advantage
Jiangxi Jinfeng Pharmaceutical Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Chembest Research Laboratories Limited 61
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64

View Latest Price from 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2,3,4-Tetrahydrobenzo[b]azepin-5-one pictures 2026-08-25 1,2,3,4-Tetrahydrobenzo[b]azepin-5-one
1127-74-8
 $1.10-9.90 1kg 99%min 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one pictures 2026-08-13 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
1127-74-8
 1G 99% 2000 Shenzhen Nexcon Pharmatechs Ltd.
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one pictures 2025-12-24 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
1127-74-8
 1KG 98.0% 10 Shaanxi Dideu Medichem Co. Ltd

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Spectrum

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one(1127-74-8)1HNMR

1127-74-8 (1,2,3,4-Tetrahydro-benzo[b]azepin-5-one) Related Search:

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 3-AMINO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE
8-METHOXY-2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE 8-Amino-1,3,4,5-tetrahydrobenzo[b]azepine-2-one 1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one 2H-1-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-methoxy- 7-AMINO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE
8-Chloro-1,2,3,4-tetrahydro-benzo[b]azepin-5-one 7-Bromo-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 2,3,4,5-Tetrahydro-benzo[c]azepin-1-one 4-Bromo-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one 7-Nitro-1,3,4,5-tetrahydro-benzo[b]azepin-2-one
1H-[1]-Benzazephe-2,5(3H, 4H)-dione 7-Bromo-1,2,3,4-tetrahydro-benzo[b]azepin-5-one 7,9-Dimethyl-1,2,3,4-tetrahydro-benzo[b]azepin-5-one

1of4

1,2,3,4-tetrahydrobenzo[b]azepin-5-tone 5-oxo-2,3,4,5-tetrahydro-1H-benzazepine 5H-1-Benzazepin-5-one, 1,2,3,4-tetrahydro- 1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 1,2,3,4-Tetrahydrobenzoazepine-5-one 1,2,3,4-Tetrahydrobenzazepine-5-one, 97% 1,2,3,4-Tetrahydro-5H-1-benzazepin-5-one 3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 3,4-Dihydro-1H-benzo[b]azepin-5(2H)-one 96% Tovaptan impurity 13 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one, CAS 1127-74-8 1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 1,2,3,4-Tetrahydro-1-benzazepin-5-one 1127-74-8 Building Blocks/Intermediates pharmacetical