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ChemicalBook >> CAS DataBase List >>1,2,3,4-Tetrahydro-benzo[b]azepin-5-one

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Structure
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one structure
CAS No.
1127-74-8
Chemical Name:
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
Synonyms
Tovaptan impurity 13;1,2,3,4-Tetrahydrobenzoazepine-5-one;1,2,3,4-Tetrahydro-1-benzazepin-5-one;1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE;5-oxo-2,3,4,5-tetrahydro-1H-benzazepine;1,2,3,4-tetrahydrobenzo[b]azepin-5-tone;3,4-dihydro-1H-benzo[b]azepin-5(2H)-one;2,3,4,5-tetrahydro-1H-1-benzazepin-5-one;1,2,3,4-Tetrahydro-5H-1-benzazepin-5-one;1,2,3,4-Tetrahydrobenzazepine-5-one, 97%
CBNumber:
CB2357010
Molecular Formula:
C10H11NO
Molecular Weight:
161.2
MDL Number:
MFCD03426404
MOL File:
1127-74-8.mol
Last updated:2025-08-18 19:12:29
Product description Number Pack Size Price
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one P991965 50mg $45
1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 95.00% CHM0017090 500MG $791.52
1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 95.00% CHM0017090 1G $866.13
1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 95.00% CHM0017090 5G $1473.32
1,2,3,4-Tetrahydrobenzo[b]azepin-5-one X9031 1g $27
More product size
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1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Properties

Boiling point 314.6±12.0 °C(Predicted)
Density 1.100±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka 3.05±0.20(Predicted)
form Powder
color White to light green
InChI InChI=1S/C10H11NO/c12-10-6-3-7-11-9-5-2-1-4-8(9)10/h1-2,4-5,11H,3,6-7H2
InChIKey NKRKBYFBKLDCFB-UHFFFAOYSA-N
SMILES N1C2=CC=CC=C2C(=O)CCC1
CAS DataBase Reference 1127-74-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H332-H335-H312-H319-H302
Precautionary statements  P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P261-P271-P304+P340-P312
HazardClass  IRRITANT
HS Code  2933998090

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC P991965 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 1127-74-8 50mg $45 2021-12-16 Buy
American Custom Chemicals Corporation CHM0017090 1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 95.00% 1127-74-8 500MG $791.52 2021-12-16 Buy
American Custom Chemicals Corporation CHM0017090 1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 95.00% 1127-74-8 1G $866.13 2021-12-16 Buy
American Custom Chemicals Corporation CHM0017090 1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 95.00% 1127-74-8 5G $1473.32 2021-12-16 Buy
AK Scientific X9031 1,2,3,4-Tetrahydrobenzo[b]azepin-5-one 1127-74-8 1g $27 2021-12-16 Buy
Product number Packaging Price Buy
P991965 50mg $45 Buy
CHM0017090 500MG $791.52 Buy
CHM0017090 1G $866.13 Buy
CHM0017090 5G $1473.32 Buy
X9031 1g $27 Buy

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Chemical Properties,Uses,Production

Synthesis

Polyphosphoric acid (25g) was heated at 100°C under nitrogen until it could be stirred. 1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydro-benzo[b]azepin-5-one (2.6g, 8.2 6mmol) was added portion-wise and the reaction mixture was heated at 100°C for 1.5h. It was poured into ice and basified with 2M NaOH(aq). The aqueous layer was extracted twice with dichloromethane. The organic extracts were combined, washed with brine, dried and reduced in vacuo. The residue was purified by flash chromatography on silica gel (eluant; 40percent EtOAc: 60percent hexane) to yield 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one (1.05g, 79percent).

References

[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 19, p. 8670 - 8692
[2] Patent: WO2006/21213, 2006, A2. Location in patent: Page/Page column 34
[3] Patent: WO2005/37796, 2005, A1. Location in patent: Page/Page column 39
[4] Journal of Organic Chemistry, 2016, vol. 81, # 8, p. 3136 - 3148

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Preparation Products And Raw materials

Raw materials

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE

Preparation Products

2,3,4,5-Tetrahydro-1H-benzo[b]azepine

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Suppliers

Global( 203)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696 +86-17392712697 1022@dideu.com China 3996 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16516 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29734 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21620 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2972 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58

View Lastest Price from 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2,3,4-Tetrahydrobenzo[b]azepin-5-one pictures 2025-10-13 1,2,3,4-Tetrahydrobenzo[b]azepin-5-one
1127-74-8
 US $1.10-9.90 / kg 1kg 99%min 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one pictures 2024-07-14 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
1127-74-8
 US $0.10 / KG 1KG 98.0% 10 Shaanxi Dideu Medichem Co. Ltd
1,2,3,4-Tetrahydro-benzo[b]azepin-5-one pictures 2019-07-06 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
1127-74-8
 US $1.00 / KG 1KG 99% 1000KG Career Henan Chemical Co

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one Spectrum

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one(1127-74-8)1HNMR

1127-74-8(1,2,3,4-Tetrahydro-benzo[b]azepin-5-one)Related Search:

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 3-AMINO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 8-METHOXY-2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE
1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE 7-BROMO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 4-BROMO-1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE 1H-[1]-BENZAZEPHE-2,5(3H, 4H)-DIONE
7,9-DIMETHYL-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE 7-AMINO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 7-BROMO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 8-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE
8-AMINO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 8-METHOXY-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 7-NITRO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE

1of4

1,2,3,4-tetrahydrobenzo[b]azepin-5-tone 5-oxo-2,3,4,5-tetrahydro-1H-benzazepine 5H-1-Benzazepin-5-one, 1,2,3,4-tetrahydro- 1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 1,2,3,4-Tetrahydrobenzoazepine-5-one 1,2,3,4-Tetrahydrobenzazepine-5-one, 97% 1,2,3,4-Tetrahydro-5H-1-benzazepin-5-one 3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 3,4-Dihydro-1H-benzo[b]azepin-5(2H)-one 96% 1,2,3,4-Tetrahydro-1-benzazepin-5-one Tovaptan impurity 13 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one, CAS 1127-74-8 1127-74-8 Building Blocks/Intermediates pharmacetical