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1,3-DI-BOC-2-METHYLISOTHIOUREA

1,3-DI-BOC-2-METHYLISOTHIOUREA structure

CAS No.: 107819-90-9

Chemical Name:: 1,3-DI-BOC-2-METHYLISOTHIOUREA

Synonyms: 1,3-BIS(TERT-BUTOXYCARBONYL)-2-METHYL-2-THIOPSEUDOUREA;3-DI-BOC-2-METHYLISOTHIOUREA;1,3-DI-BOC-2-METHYLISOTHIOURE;1,3-DI-BOC-2-METHYLISOTHIOUREA;N,N'-DI-BOC-S-METHYLISOTHIOUREA;Bis(Boc)-2-methyl-2-thiopseudourea;N,N'-Di-BOC-S-methylisothiourea 97%;Methyl N,N'-Di-Boc-carbamimidothioate;1,3-Bis-Boc-2-methyl-2-thiopseudourea;1,3-Bis(t-butoxycarbonyl)-2-methylisothiourea

CBNumber:: CB6123543

Molecular Formula:: C12H22N2O4S

Molecular Weight:: 290.38

MDL Number:: MFCD00239356

MOL File:: 107819-90-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:09:03

Product description	Number	Pack Size	Price
1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea 98%	439908	5g	$155
1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea 98%	439908	25g	$606
N,N'-Bis(tert-butoxycarbonyl)-S-methylisothiourea >98.0%(HPLC)(N)	B4535	5g	$63
N,N'-Bis(tert-butoxycarbonyl)-S-methylisothiourea >98.0%(HPLC)(N)	B4535	25g	$216
1,3-di-Boc-2-methylisothiourea Asreported	273396	5g	$502
More product size

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1,3-DI-BOC-2-METHYLISOTHIOUREA Properties

Melting point	115-121 °C(lit.)
Density	1.10±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Acetonitrile (Very Slightly), Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	6.77±0.46(Predicted)
color	White to Off-White
BRN	5815984
Major Application	peptide synthesis
InChI	InChI=1S/C12H22N2O4S/c1-11(2,3)17-9(15)13-8(19-7)14-10(16)18-12(4,5)6/h1-7H3,(H,13,14,15,16)
InChIKey	UQJXXWHAJKRDKY-UHFFFAOYSA-N
SMILES	C(OC(C)(C)C)(=O)N=C(NC(OC(C)(C)C)=O)SC
UNSPSC Code	12352200
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	24/25
WGK Germany	3
HS Code	29309090
Storage Class	11 - Combustible Solids

1,3-DI-BOC-2-METHYLISOTHIOUREA price More Price(88)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	439908	1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea 98%	107819-90-9	5g	$155	2026-04-30	Buy
Sigma-Aldrich	439908	1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea 98%	107819-90-9	25g	$606	2026-04-30	Buy
TCI Chemical	B4535	N,N'-Bis(tert-butoxycarbonyl)-S-methylisothiourea >98.0%(HPLC)(N)	107819-90-9	5g	$63	2026-04-30	Buy
TCI Chemical	B4535	N,N'-Bis(tert-butoxycarbonyl)-S-methylisothiourea >98.0%(HPLC)(N)	107819-90-9	25g	$216	2026-04-30	Buy
Usbiological	273396	1,3-di-Boc-2-methylisothiourea Asreported	107819-90-9	5g	$502	2026-06-03	Buy

Product number	Packaging	Price	Buy
439908	5g	$155	Buy
439908	25g	$606	Buy
B4535	5g	$63	Buy
B4535	25g	$216	Buy
273396	5g	$502	Buy

1,3-DI-BOC-2-METHYLISOTHIOUREA Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder

Uses

Reagent for the guanylation of amines.

Synthesis

24424-99-5

867-44-7

107819-90-9

E) Preparation of N,N'-di-Boc-S-methylisothiourea: Di-tert-butyl dicarbonate (100 g, 458 mmol) was dissolved in tert-butanol (300 mL) under stirring conditions. Subsequently, a solution of S-methylisothiourea sulfate (32.7 g, 117 mmol) in water (150 mL) was slowly added, followed by dropwise addition of sodium hydroxide (19.2 g, 480 mmol) in water (150 mL). The reaction mixture was stirred continuously for 48 hours at room temperature. Upon completion of the reaction, the mixture was concentrated to one-third of the original volume under reduced pressure and then diluted with ether (500 mL). The organic phase was separated and washed once with water (250 mL), three times with 1N citric acid solution (250 mL), and again with water (250 mL), in that order. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 42 g (62% yield) of white solid product.

References

[1] Journal of Organic Chemistry, 1987, vol. 52, # 9, p. 1700 - 1703
[2] Patent: US5914319, 1999, A
[3] Patent: US5705487, 1998, A
[4] Patent: US5710130, 1998, A
[5] Patent: US5726159, 1998, A

1,3-DI-BOC-2-METHYLISOTHIOUREA synthesis

Synthesis of 1,3-DI-BOC-2-METHYLISOTHIOUREA from Di-tert-butyl dicarbonate and 2-Methyl-2-thiopseudourea sulfate

1,3-DI-BOC-2-METHYLISOTHIOUREA Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate Sodium hydroxide tert-Butanol 2-Methyl-2-thiopseudourea sulfate Citric acid

Preparation Products

1,3-DI-BOC-2-METHYLISOTHIOUREA Suppliers

Global( 178)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
PharmOrgSyn Laboratories Co., Ltd.	+86-021-38228826 +86-13916602830	sales@pharmorgsyn.cn	China	139	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Alfa Chemistry	--	info@alfa-chemistry.com	United States	2344	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52704	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58

Supplier	Advantage
PharmOrgSyn Laboratories Co., Ltd.	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Biochempartner	58
Accela ChemBio Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
Alfa Chemistry	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Nextpeptide Inc	58

View Lastest Price from 1,3-DI-BOC-2-METHYLISOTHIOUREA manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea 107819-90-9	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
	2019-08-06	1,3-DI-BOC-2-METHYLISOTHIOUREA 107819-90-9	$1.00	1KG	98%	10KG	Career Henan Chemical Co

1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea
107819-90-9
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1,3-DI-BOC-2-METHYLISOTHIOUREA
107819-90-9
$1.00
98%
Career Henan Chemical Co

1,3-DI-BOC-2-METHYLISOTHIOUREA Spectrum

1,3-DI-BOC-2-METHYLISOTHIOUREA(107819-90-9)¹HNMR 1,3-DI-BOC-2-METHYLISOTHIOUREA(107819-90-9)FT-IR 1,3-DI-BOC-2-METHYLISOTHIOUREA(107819-90-9)IR

107819-90-9(1,3-DI-BOC-2-METHYLISOTHIOUREA)Related Search:

N-Boc-cadaverine N,N'-Disuccinimidyl carbonate Chloro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate 1,3-Bis(methoxycarbonyl)-2-methyl-2-thiopseudoeura 1,3-DI-BOC-2-METHYLISOTHIOUREA

N,N'-DI-BOC-S-METHYLISOTHIOUREA N,N'-BIS(TERT-BUTOXYCARBONYL)-S-METHYLISOTHIOUREA 1,3-DI-BOC-2-METHYLISOTHIOUREA 1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseud 1,3-Di-Boc-2-methylisothiourea, N,Nμ-Di-Boc-S-methylisothiourea, N,Nμ-Bis(tert-butoxycarbonyl)-S-methylisothiourea 1,3-Di-Boc-2-methylisothiourea, N,Nμ-Bis(tert-butoxycarbonyl)-S-methylisothiourea CarbaMic acid,N-[[[(1,1-diMethylethoxy)carbonyl]aMino](Methylthio)Methylene]-,1,1- 1,3-di-(tert-butoxycarbonyl)-2-Methylisothiourea [[[(1,1-Dimethylethoxy)carbonyl]amino](methylthio)methylene]carbamic acid 1,1-dimethylethyl ester 1,3-Bis(tert-butoxycarbonyl)-2-methylisothiourea 1,3-Bis(tert-butoxycarbonyl)-2-methylthiopseudourea 1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea,95% 1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea,1,3-Di-Boc-2-methylisothiourea, N,N′-Bis(tert-butoxycarbonyl)-S-methylisothiourea, N,N′-Di-Boc-S-methylisothiourea N,N'-Di-BOC-S-methylisothiourea 97% N,N'-Bis(tert-butoxycarbonyl)carbamimidothioic Acid Methyl Ester 1,3-Di-tert-butyloxycarbonyl-S-methylisothiourea Bis(Boc)-2-methyl-2-thiopseudourea N,N'-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea N,N'-Di(tert-butoxycarbonyl)-S-methylisothiourea N,N'-Bis(tert-butoxycarbonyl)-S-methylisothiourea≥ 98% (TLC) 1,3-DI-BOC-2-METHYLISOTHIOURE 1,3-Bis-(tert-butoxycarbonyl)-2-methyl-2-thiopseudiurea CarbaMic acid,N-[[[(1,1-diMethylethoxy)carbonyl]aMino](Methylthio)Methylene]-,1,1-diMethylethyl ester 1,3-Bis(t-butoxycarbonyl)-2-methylisothiourea N,N'-Bis(tert-butoxycarbonyl)-S-methylisothiourea > Methyl N,N'-Bis(tert-butoxycarbonyl)carbamimidothioate Methyl N,N'-Di-Boc-carbamimidothioate N,N'-Di-Boc-carbamimidothioic Acid Methyl Ester 3-DI-BOC-2-METHYLISOTHIOUREA tert-butyl N-[(Z)-{[(tert-butoxy)carbonyl]amino}(methylsulfanyl)methylidene]carbamate 1,3-Bis-Boc-2-methyl-2-thiopseudourea 1,1-Dimethylethyl N-[[[(1,1-dimethylethoxy)carbonyl]amino](methylthio)methylene]carbamate tert-Butyl N--(N-BOC-amino)-(methylthio)methylenecarbamate 1,1-Dimethylethyl N-[[[(1,1-dimethylethoxy)carbonyl]amino](methylthio)methylene]carbamate (ACI) 1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea 1,3-BIS(TERT-BUTOXYCARBONYL)-2-METHYL-2-THIOPSEUDOUREA 107819-90-9 CH33CO2CNCSCH3NHCO2CCH33 C12H22N2O4S Guanidine Protection/Guanidinylation Specialty Synthesis Peptide Synthesis