3-Iodo-4-methoxy-pyridine
- CAS No.
- 89640-55-1
- Chemical Name:
- 3-Iodo-4-methoxy-pyridine
- Synonyms
- 3-Iodo-4-methoxy-pyridine;Pyridine, 3-iodo-4-methoxy-
- CBNumber:
- CB6127420
- Molecular Formula:
- C6H6INO
- Molecular Weight:
- 235.02
- MDL Number:
- MFCD01416617
- MOL File:
- 89640-55-1.mol
- MSDS File:
- SDS
| Melting point | 78 °C(Solv: ligroine (8032-32-4)) |
|---|---|
| Boiling point | 271.2±25.0 °C(Predicted) |
| Density | 1.825±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 4.52±0.18(Predicted) |
| form | solid |
| Appearance | White to yellow Solid |
| InChI | InChI=1S/C6H6INO/c1-9-6-2-3-8-4-5(6)7/h2-4H,1H3 |
| InChIKey | WZAPSURIRLYQEJ-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(OC)=C1I |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
3-Iodo-4-methoxy-pyridine price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000651 | 3-Iodo-4-methoxypyridine Aldrich | 89640-55-1 | 1g | $870 | 2026-04-30 | Buy |
| Activate Scientific | AS47141 | 3-Iodo-4-methoxypyridine 98% | 89640-55-1 | 1g | $55 | 2026-06-04 | Buy |
| Activate Scientific | AS47141 | 3-Iodo-4-methoxypyridine 98% | 89640-55-1 | 5g | $176 | 2026-06-04 | Buy |
| Activate Scientific | AS47141 | 3-Iodo-4-methoxypyridine 98% | 89640-55-1 | 25g | $548 | 2026-06-04 | Buy |
| Synthonix | K42934 | 3-Iodo-4-methoxypyridine 98% | 89640-55-1 | 250mg | $68 | 2026-05-06 | Buy |
3-Iodo-4-methoxy-pyridine Chemical Properties, Uses, Production
Synthesis
620-08-6
89640-55-1
The general procedure for the synthesis of 3-iodo-4-methoxypyridine from 4-methoxypyridine was as follows: n-butyllithium (ca. 1.6 M hexane solution, 1.5 mmol) was sequentially added to a stirred solution of 2,2,6,6-tetramethylpiperidine (0.25 mL, 1.5 mmol) in tetrahydrofuran (THF, 2-3 mL) at 0 °C. After 5 min, n-butyllithium (ca. 1.6 M hexane solution, 1.5 mmol) was added. ZnCl2TMEDA complex (0.13 g, 0.50 mmol). The reaction mixture was continued to be stirred at 0 °C for 15 min and then 4-methoxypyridine (1.0 mmol) was added at 0-10 °C. After the reaction mixture was stirred for 2 h at room temperature, a THF (4 mL) solution of iodine (I2, 0.38 g, 1.5 mmol) was added. After the mixture was stirred overnight, the reaction was quenched by the addition of saturated aqueous sodium thiosulfate (Na2S2O3) solution (4 mL) and extracted with ethyl acetate (AcOEt, 320 mL). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. Finally, the target product, 3-iodo-4-methoxypyridine, was purified by silica gel column chromatography (eluent given in the product specification).
References
[1] Tetrahedron, 2016, vol. 72, # 17, p. 2196 - 2205
[2] Tetrahedron, 1993, vol. 49, # 37, p. 8373 - 8380
[3] Tetrahedron Letters, 2011, vol. 52, # 36, p. 4590 - 4594
[4] Chemical Communications, 2014, vol. 50, # 85, p. 12859 - 12862
[5] Chemistry - A European Journal, 2013, vol. 19, # 24, p. 7944 - 7960
3-Iodo-4-methoxy-pyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
| Shanghai Carlow Chemicals Co., Ltd. | 21-33526724 18930996265 | info@carlowchem.com | China | 1996 | 58 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189;18621755571 | mychess007@163.com | China | 1994 | 55 |
View Latest Price from 3-Iodo-4-methoxy-pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | 3-Iodo-4-methoxypyridine
89640-55-1
|
$9.80 | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- 3-Iodo-4-methoxypyridine
89640-55-1
- $9.80
- ≥98%
- Career Henan Chemical Co
