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(1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride

(1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride structure

CAS No.: 87269-87-2

Chemical Name:: (1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride

Synonyms: Ramipril Intermediate;Ramipril Intermediate2;(2S,3aS,6aS)-Octahydrocyclopenta[b];Imidapril Impurity 19(Hydrochloride);Midapril impurity 19 (hydrochloride);(S,S,S)-2-AZABICYCLO (3,3,0) OCTANE CAR&;Benzyl (cis, endo) octahydrocyclopenta (Ramipril int);(3S)-BENZYL ENDO CIS-2-AZABICYCLO (3,3,0)-OCTANE HYDROCHLORIDE;(1s,3s,5s)-2-azabicyclo(3,3,0)octane-3-carboxylic acid benzy...;(1s,3s,5s)-2-azabicyclo(3,3,0)octane-3-carborylic acid benzyl ester

CBNumber:: CB6129000

Molecular Formula:: C15H20ClNO2

Molecular Weight:: 281.78

MDL Number:: MFCD04974076

MOL File:: 87269-87-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:59:37

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(1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride Properties

Melting point	176-180 °C(lit.)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Sparingly, Heated), Methanol (Slightly), Water (Slightly)
form	Solid
color	White to Off-White
optical activity	[α]20/D -26°, c = 1% in DMSO
Stability	Hygroscopic
InChI	1S/C15H19NO2.ClH/c17-15(18-10-11-5-2-1-3-6-11)14-9-12-7-4-8-13(12)16-14;/h1-3,5-6,12-14,16H,4,7-10H2;1H/t12-,13-,14-;/m0./s1
InChIKey	HLXCXOQXUDRJLF-JKBZPBJLSA-N
SMILES	Cl[H].[H][C@@]12CCC[C@]1([H])N[C@@H](C2)C(=O)OCc3ccccc3
UNSPSC Code	12352005

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08,GHS02
Signal word	Danger
Hazard statements	H304-H413-H225
Precautionary statements	P501-P273-P240-P210-P233-P243-P241-P242-P280-P370+P378-P331-P303+P361+P353-P301+P310-P403+P235-P405
PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	22-24/25
WGK Germany	3
HS Code	2933.99.9701
Storage Class	11 - Combustible Solids
REACH Registrations	Active

(1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	570907	Benzyl (S,S,S)-2-azabicyclo[3.3.0]octane-3-carboxylate hydrochloride 97%	87269-87-2	5g	$634	2023-06-20	Buy
Sigma-Aldrich	570907	Benzyl (S,S,S)-2-azabicyclo[3.3.0]octane-3-carboxylate hydrochloride 97%	87269-87-2	1g	$133	2023-01-07	Buy
TCI Chemical	B5344	Benzyl (S,S,S)-2-Azabicyclo[3.3.0]octane-3-carboxylate Hydrochloride >98.0%(HPLC)(T)	87269-87-2	1g	$56	2026-04-30	Buy
TCI Chemical	B5344	Benzyl (S,S,S)-2-Azabicyclo[3.3.0]octane-3-carboxylate Hydrochloride >98.0%(HPLC)(T)	87269-87-2	5g	$222	2026-04-30	Buy
Usbiological	A4930-03	(S,S,S)-2-Azabicyclo[3.3.0]octane-3-carboxylic Acid, Benzyl Ester, Hydrochloride		1g	$418	2026-06-03	Buy

Product number	Packaging	Price	Buy
570907	5g	$634	Buy
570907	1g	$133	Buy
B5344	1g	$56	Buy
B5344	5g	$222	Buy
A4930-03	1g	$418	Buy

(1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride Chemical Properties, Uses, Production

Synthesis

2-Benzoylamino-3-(2-oxocyclopentyl)propionate ethyl ester was synthesized from benzamide and ethyl pyruvate via condensation and addition reactions. Further hydrolysis, cyclization, and hydrogenation yielded the key intermediate of ramipril, (1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride. The synthetic reaction formula is shown in the figure below:

Synthesis of 87269-87-2

Chemical Properties

Thick Yellow Oil

Uses

Benzyl (S,S,S)-2-azabicyclo[3.3.0]octane-3-carboxylate hydrochloride can be used:

In the preparation of ramipril, an angiotensin-converting enzyme (ACE) inhibitor.
As a starting material for the synthesis of octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as potent DPP4 inhibitors.

Uses

In intermediate in the synthesis of Ramipril

(1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride Suppliers

Global Suppliers ( 209)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6741	52
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	7909	65
Tianjin heowns Biochemical Technology Co., Ltd.	400 638 7771	sales@heowns.com	China	14412	57
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9874	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
ShangHai DEMO Chemical Co.,Ltd	57
Energy Chemical	61
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
XiaoGan ShenYuan ChemPharm co,ltd	52
Daicel Chiral Technologies (China)CO.,LTD	65
Tianjin heowns Biochemical Technology Co., Ltd.	57
Shanghai Topbiochem Technology Co., Ltd	58
Shanghai T&W Pharmaceutical Co., Ltd.	58

View Latest Price from (1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-08	(1S,3S,5S)-2-Azabicyclo[3,3,0] –octan-carboxylic acid benzylester hydrochloride 87269-87-2		1kg	99.0%	20 tons	Hangzhou ICH Biofarm Co., Ltd
2026-03-12	Imidapril Impurity 19(Hydrochloride) 87269-87-2		10mg	98%	500mg	ShenZhen H&D Pharmaceutical Technology Co., LTD
2019-07-06	(1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride 87269-87-2	$1.00	1KG	98%	1kg,5kg,100kg	Career Henan Chemical Co

(1S,3S,5S)-2-Azabicyclo[3,3,0] –octan-carboxylic acid benzylester hydrochloride
87269-87-2
99.0%
Hangzhou ICH Biofarm Co., Ltd

Imidapril Impurity 19(Hydrochloride)
87269-87-2
98%
ShenZhen H&D Pharmaceutical Technology Co., LTD

(1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride
87269-87-2
$1.00
98%
Career Henan Chemical Co

(1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride Spectrum

(1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride(87269-87-2)¹HNMR

87269-87-2 ((1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride) Related Search:

Benzyl chloride Benzoyl peroxide Benzyl acetate Benzyl benzoate Benzyl butyrate

Benzyl alcohol 1-Octanesulfonic acid, sodium salt, monohydrate n-Octane 2-Azabicyclo[3.3.0]octane-3-carboxylic acid (S,S)-2-Azabicyclo[3,3,0]-octane-3-carboxylic acid benzylester hydrochloride

(S,S,S)-2-Azabicyclo[3,3,0]-octane-carboxylic acid benzylester hydrochloride Benzyl AcidEster L-Proline benzyl ester hydrochloride 3-Cyclopentane-L-alanine

Ethyl L-leucinate hydrochloride Methyl L-prolinate hydrochloride N-Cyclopentyl-amino-acetic acid ethyl ester HCl

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(1S,3S,5S)-2-azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride (1S, 3S, 5S)-2-Azabicyclo[3,3,0]Octane-3-Carborylic Acid Benzyl Ester hydrochlor (S,S,S)-2-AZABICYCLO (3,3,0) OCTANE CAR& (3S)–BENZYL CIS ENDO–2–AZABICYCLO [3.3.0] –OCTANE–3–CARBOXYLATE HYDROCHLORIDE (3S)-BENZYL ENDO CIS-2-AZABICYCLO (3,3,0)-OCTANE HYDROCHLORIDE BENZYL (S,S,S)-2-AZABICYCLO[3.3.0]OCTANE-3-CARBOXYLATE HYDROCHLORIDE ENDO, CIS-2-AZABICYCLO [3.3.0] OCTANE-3-CARBOXYLIC ACID BENZYL ESTER HYDROCHLORIDE CIS,ENDO-2-AZABICYCLO[3,3,0]OCTANE-3-CARBOXYLIC ACID BENZYL ESTER HYDROCHLORIDE (S,S,S)-2-AZABICYCLO[3,3,0]-OCTANE-3-CARBOXYLIC ACID BENZYL ESTER HYDROCHLORIDE Ramipril Intermediate2 6-(phenylmethyl)-1,2,3,3a,4,5,6,6a-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride (1s,3s,5s)-2-azabicyclo(3,3,0)octane-3-carborylic acid benzyl ester benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride (1S,3S,5S)-2-AZABICYCLO[3,3,0]OCTANE-3-CARBORYLICACIDBENZYLESTERHYDROCHLORIDE(FORRAMIPRIL) (S,S,S)-Octahydro-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester HCl (S,S,S)-Octahydro-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester hydrochloride (S,S,S)-2-Azabicyclo-[3,3,0]-octane carboxylic acid benzylester hydrochloride, (S,S,S)-2-Azabicyclo[3,3,0]octane-3-carboxylic acid benzyl ester hydrochloride (S,S,S)-2-Azabicyclo[3,3,0]-Octane-Carboxylic Acid Benzyl Ester Hydroxychloride (2S,3aS,6aS)-Benzyl octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride Ramipril Intermediate (2S,3aS,6aS)-octahydro-Cyclopenta[b]pyrrole-2-carboxylic acid, Benzyl Ester, HCl (2S,3aS,6aS)-Octahydrocyclopenta[b] Cyclopenta[b]?pyrrole-2-carboxylic acid, octahydro-, phenylmethyl ester, hydrochloride (1:1), (2S,3aS,6aS) (1s,3s,5s)-2-azabicyclo(3,3,0)octane-3-carboxylic acid benzy... (2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic Acid Phenylmethyl Ester Hydrochloride (1S,3S,5S)-2-Azabicyclo[3,3,0] –octan-carboxylic acid benzylester hydrochloride (1S, 3S, 5S) -2-azabicyclic [3,3,0] octane-3-carboxylic acid benzyl ester hydrochloride Benzyl (cis, endo) octahydrocyclopenta (Ramipril int) Benzyl (1S,3S,5S)-2-azabicyclo[3,3,0]octane-3-carboxylate hydrochloride (1S, 3S, 5S) -2-Azabicyclo [3,3,0] octane-3-carboxylate benzyl ester hydrochloride (1S, 3S, 5S) -2-Azabicyclo [3,3,0] octan-3-carboxylic acid benzyl ester hydrochloride Imidapril Impurity 19(Hydrochloride) Midapril impurity 19 (hydrochloride) Benzyl (S,S,S)-2-azabicyclo[3.3.0]octane-3-carboxylate hydrochloride Ramipril Impurity as hydrochloride: (2S,3aS,6aS)-Octahydro-cyclopenta[b]pyrrole-2-carboxylic Acid Phenyl methyl Ester hydrochloride benzyl (2S,3aS,6aS)-1,2,3,3a,4,5,6,6a-octahydrocyclopenta[b]pyrrole-2-carboxylate 87269-87-2 Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Pharmaceutical Intermediates