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L-Proline benzyl ester hydrochloride

L-Proline benzyl ester hydrochloride structure

CAS No.: 16652-71-4

Chemical Name:: L-Proline benzyl ester hydrochloride

Synonyms: H-PRO-OBZL;L-Pro-OBzl.HCl;L-PROLINE BENZYL ESTER;benzyl L-prolinate hydrochloride;PRO-OBZL HCL;H-Pro-Obzl.Hc;H-PRO-OBZL HCL;H-PRO-OBZL·HCL;H-Pro-OBzI.HCI;H-Pro-OBzl.HCI

CBNumber:: CB6426051

Molecular Formula:: C12H16ClNO2

Molecular Weight:: 241.71

MDL Number:: MFCD00039002

MOL File:: 16652-71-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:22:41

Product description	Number	Pack Size	Price
L-Proline benzyl ester hydrochloride 98%	364460	5g	$40
L-Proline Benzyl Ester Hydrochloride >98.0%(HPLC)(T)	P1727	5g	$20
L-Proline Benzyl Ester Hydrochloride >98.0%(HPLC)(T)	P1727	25g	$56
L-Proline benzyl ester hydrochloride Asreported	287761	10g	$333
L-Proline benzyl ester hydrochloride Asreported	287761	25g	$456
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L-Proline benzyl ester hydrochloride Properties

Melting point	148-151 °C(lit.)
alpha	-44 º (c=1, methanol)
refractive index	1.4365
storage temp.	Inert atmosphere,Room Temperature
solubility	soluble in Methanol
form	Crystalline Powder
color	White to pale yellow
optical activity	[α]20/D 48°, c = 1 in H2O
Water Solubility	miscible
Sensitive	Hygroscopic
BRN	3598081
Major Application	peptide synthesis
InChI	InChI=1/C12H15NO2.ClH/c14-12(11-7-4-8-13-11)15-9-10-5-2-1-3-6-10;/h1-3,5-6,11,13H,4,7-9H2;1H/t11-;/s3
InChIKey	NEDMOHHWRPHBAL-MERQFXBCSA-N
SMILES	[C@@H]1(NCCC1)C(=O)OCC1=CC=CC=C1.Cl \|&1:0,r\|
CAS DataBase Reference	16652-71-4(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P271-P280

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Xi,Xn

Risk Statements

36/38-36/37/38-22

Safety Statements

22-24/25-37/39-26-36/37/39

WGK Germany

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		1

L-Proline benzyl ester hydrochloride price More Price(61)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	364460	L-Proline benzyl ester hydrochloride 98%	16652-71-4	5g	$40	2026-04-30	Buy
TCI Chemical	P1727	L-Proline Benzyl Ester Hydrochloride >98.0%(HPLC)(T)	16652-71-4	5g	$20	2026-04-30	Buy
TCI Chemical	P1727	L-Proline Benzyl Ester Hydrochloride >98.0%(HPLC)(T)	16652-71-4	25g	$56	2026-04-30	Buy
Usbiological	287761	L-Proline benzyl ester hydrochloride Asreported	16652-71-4	10g	$333	2026-06-03	Buy
Usbiological	287761	L-Proline benzyl ester hydrochloride Asreported	16652-71-4	25g	$456	2026-06-03	Buy

Product number	Packaging	Price	Buy
364460	5g	$40	Buy
P1727	5g	$20	Buy
P1727	25g	$56	Buy
287761	10g	$333	Buy
287761	25g	$456	Buy

L-Proline benzyl ester hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

L-Proline Benzyl Ester Hydrochloride acts as a reagent in the synthesis and bioactivity of a goralatide analog with anti-leukemic activity.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

147-85-3

100-51-6

16652-71-4

Under nitrogen protection, benzyl alcohol (70 mL, 651 mmol) was cooled to 0 °C and thionyl chloride (7.0 mL, 91.2 mmol) was added slowly and dropwise. L-proline (5.0 g, 43.4 mmol) was then added, and the reaction system was kept stirred at 0 °C and under nitrogen atmosphere for 2 hours. The temperature was slowly increased to room temperature and stirring was continued for 48 hours. Upon completion of the reaction, the reaction mixture was slowly poured into ether (300 mL) and left to crystallize at -20°C for 7 days. The resulting white solid precipitate was collected by filtration, washed with ether and dried under vacuum to give L-proline benzyl ester hydrochloride (9.88 g, 93% yield). The product characterization data were as follows: melting point 142.1-144.0 °C (literature value: 143-144 °C); 1H NMR (300 MHz, CDCl3): δ 7.41-7.21 (m, 5H), 5.16 (s, 2H), 3.80 (dd, J = 3.83, 5.9 Hz, 1H), 3.15-3.01 (m, 1H), 3.00-2.82 (m, 1H), 2.42-2.21 (m, 1H), 2.13 (dd, J = 12.9, 7.5 Hz, 1H), 1.92-1.62 (m, 3H); 13C NMR (75 MHz, CDCl3): δ 175.5, 136.0, 128.8, 128.5, 128.3, 66.9, 59.9, 47.2, 30.4, 25.6. Elemental analysis (C12H16ClNO2) calculated values: C, 59.63; H, 6.67; N, 5.79; measured values: C, 59.50; H, 6.86; N, 5.64.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 5056 - 5060
[2] Tetrahedron, 2010, vol. 66, # 29, p. 5384 - 5395
[3] Patent: CN105061283, 2017, B. Location in patent: Paragraph 0030-0032; 0045-0047; 0057
[4] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1959, p. 1851; engl. Ausg. S. 1768, 1769
[5] Journal of Biological Chemistry, 1951, vol. 193, p. 97,108

L-Proline benzyl ester hydrochloride synthesis

Synthesis of L-Proline benzyl ester hydrochloride from L-Proline and Benzyl alcohol

L-Proline benzyl ester hydrochloride Preparation Products And Raw materials

Raw materials

1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester, (2S)- L-Proline BOC-L-Proline Benzyl alcohol

Preparation Products

L-Proline benzyl ester hydrochloride Suppliers

Global( 374)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	Brad@rongnabiotech.com	China	3371	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	988	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114	sales@amoychem.com	China	6361	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58

Supplier	Advantage
RongNa Biotechnology Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
AB PharmaTech,LLC	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58

View Lastest Price from L-Proline benzyl ester hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-11	L-Proline benzyl ester hydrochloride 16652-71-4	$1.00	1g	99%	1000kg	RongNa Biotechnology Co.,Ltd
2025-04-04	L-Proline benzyl ester hydrochloride 16652-71-4		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	L-Proline benzyl ester hydrochloride 16652-71-4	$1.00	1KG	99%	20kg	Career Henan Chemical Co

L-Proline benzyl ester hydrochloride
16652-71-4
$1.00
99%
RongNa Biotechnology Co.,Ltd

L-Proline benzyl ester hydrochloride
16652-71-4
98%
Henan Aochuang Chemical Co.,Ltd.

L-Proline benzyl ester hydrochloride
16652-71-4
$1.00
99%
Career Henan Chemical Co

L-Proline benzyl ester hydrochloride Spectrum

L-Proline benzyl ester hydrochloride(16652-71-4)MS L-Proline benzyl ester hydrochloride(16652-71-4)¹HNMR L-Proline benzyl ester hydrochloride(16652-71-4)IR1 L-Proline benzyl ester hydrochloride(16652-71-4)IR2 L-Proline benzyl ester hydrochloride(16652-71-4)Raman

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L-PYRROLIDINE-2-CARBOXYLIC ACID BENZYL ESTER HCL L-PROLINE BENZYL ESTER HCL L-PROLINE BENZYL ESTER HYDROCHLORIDE SALT L-PROLINE BENZYL ESTER MONOHYDROCHLORIDE H-PRO-OBZL HCL PROLINE-OBZL HCL PRO-OBZL HCL 2-pyrrolidinecarboxylic acid (phenylmethyl) ester chloride (S)-Pyrrolidine-2-carboxylic acid benzyl ester hydrochloride L-Proline benzyl ester hydrochloride≥ 98% (HPLC) H-Pro-Obzl.Hc L-Proline benzyl ester hydrochloride 98% benzyl prolinate hydrochloride TIMTEC-BB SBB003206 l-proline,phenylmethylester,hydrochloride H-PRO-OBZL·HCL Proline benzyl ester hydrochloride L-PROLINE BENZYL ESTER HYDROCHLORIDE, 98 % H-L-Pro-OBzl*HCl L-Proline benzyl ester hydrochloride L-Proline benzyl est L-Proline benzyl ester hydrochloride (for Enalapril) L-Proline benzyl ester hydchloride benzyl (2S)-pyrrolidine-2-carboxylate hydrochloride H-Pro-OBzl·HCl L-Proline benzyl ester hydrochloride L-ProlineBenzylEsterHydrochloride> Proline, phenylmethyl ester, hydrochloride Benzyl pyrrolidine-2-carboxylate hydrochloride L-Proline benzyl ester hydrochloride USP/EP/BP L-Proline benzyl ester hydrochloride,16652-71-4 L-Proline Benzyl Ester Hydrochloride extrapure, 99% L-Proline, phenylmethyl ester, hydrochloride (1:1) H-Pro-OBzI.HCI H-Pro-OBzl.HCI L-Proline Benzyl Ester Hydrocloride Lisinopril intermediates L-Proline benzyl ester hydrochloride H-Pro-OBz1.HCI benzyl L-prolinate hydrochloride H-PRO-OBZL L-PROLINE BENZYL ESTER L-Pro-OBzl.HCl 16652-71-4 C12H15NO2HCI C12H15NO2ClH C12H15NO2xHCl AMINE Specialty Synthesis Peptide Synthesis Amino Acid Derivatives Proline [Pro, P] Amino Acids and Derivatives Amino Acid Benzyl Esters Amino Acids (C-Protected) Biochemistry Amino hydrochloride Amino Acid Derivatives Peptide Synthesis Proline