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Methyl L-prolinate hydrochloride

Methyl L-prolinate hydrochloride Structure
Methyl L-prolinate hydrochloride structure
CAS No.
2133-40-6
Chemical Name:
Methyl L-prolinate hydrochloride
Synonyms
L-PROLINE METHYL ESTER HYDROCHLORIDE;PROLINE METHYL ESTER HYDROCHLORIDE;L-Proline Methyl Ester Monohydrochloride;L-Pro-Ome.HCl;L-Proline methyleester hydrochloride;Methyl L-prolinate hydrochloride USP/EP/BP;L-Proline methyl ester hydrochloride≥ 99% (HPLC);Methyl (2S)-pyrrolidine-2-carboxylate hydrochloride;ine methyL;PRO-OME.HCL
CBNumber:
CB3116045
Molecular Formula:
C6H12ClNO2
Molecular Weight:
165.62
MDL Number:
MFCD00012708
MOL File:
2133-40-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:56:01
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Methyl L-prolinate hydrochloride Properties

Melting point 69-71 °C(lit.)
alpha -33 º (c=1, H2O)
Boiling point 55 °C / 11mmHg
Density 1.1426 (rough estimate)
refractive index -31.5 ° (C=1, H2O)
storage temp. Inert atmosphere,2-8°C
solubility Chloroform, Methanol (Slightly), Water (slightly)
form Crystalline Powder, Crystals, and/or Chunks
color White
optical activity [α]20/D 31°, c = 0.5 in H2O
Sensitive Hygroscopic
BRN 3596045
Stability Hygroscopic
Major Application peptide synthesis
InChI 1S/C6H11NO2.ClH/c1-9-6(8)5-3-2-4-7-5;/h5,7H,2-4H2,1H3;1H/t5-;/m0./s1
InChIKey HQEIPVHJHZTMDP-JEDNCBNOSA-N
SMILES Cl[H].[H][C@]1(CCCN1)C(=O)OC
CAS DataBase Reference 2133-40-6(CAS DataBase Reference)
FDA UNII 7LWL7P890M
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26-37/39
WGK Germany  3
F  3-8-10-21
Hazard Note  Harmful
HS Code  29189900
Storage Class 11 - Combustible Solids
NFPA 704
1
2 1

Methyl L-prolinate hydrochloride price More Price(88)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 287067 L-Proline methyl ester hydrochloride 98% 2133-40-6 1g $40 2026-04-30 Buy
Sigma-Aldrich 287067 L-Proline methyl ester hydrochloride 98% 2133-40-6 5g $111 2026-04-30 Buy
TCI Chemical P0342 L-Proline Methyl Ester Hydrochloride >98.0%(N) 2133-40-6 5g $49 2026-04-30 Buy
TCI Chemical P0342 L-Proline Methyl Ester Hydrochloride >98.0%(N) 2133-40-6 25g $180 2026-04-30 Buy
Usbiological 287050 L-Proline methyl ester hydrochloride 2133-40-6 5g $293 2026-06-03 Buy
Product number Packaging Price Buy
287067 1g $40 Buy
287067 5g $111 Buy
P0342 5g $49 Buy
P0342 25g $180 Buy
287050 5g $293 Buy

Methyl L-prolinate hydrochloride Chemical Properties, Uses, Production

Chemical Properties

Crystalline

Uses

L-Proline Methyl Ester Hydrochloride (cas# 2133-40-6) is a compound useful in organic synthesis.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Methanol

67-56-1

L-Proline

147-85-3

Methyl L-prolinate hydrochloride

2133-40-6

The general procedure for the synthesis of L-proline methyl ester hydrochloride from methanol and L-proline was as follows: first, methyl (S)-pyrrolidine-2-carboxylate was prepared by reacting (S)-proline (10.2 g, 88.6 mmol) with SOCl (11.6 g, 7.10 mL, 97.5 mmol) in refluxed methanol (60 mL) for 29 hours. Upon completion of the reaction, excess solvent and SOCl were removed by distillation under reduced pressure to afford the proline ester as a gray oil (15.9 g, quantitative yield). Subsequently, 2-fluoro-1-nitrobenzene (6.92 g, 5.18 mL, 49.0 mmol) was reacted with methyl (S)-pyrrolidine-2-carboxylate (7.55 g, 45.6 mmol) prepared as described above according to the literature method to afford bright yellow crystals of L-prolinylmethyl ester hydrochloride (12.0 g, quantitative yield), which was used without further purification for subsequent The product can be used for subsequent experiments without further purification.

References

[1] Heterocycles, 1986, vol. 24, # 4, p. 1045 - 1060
[2] Bulletin des Societes Chimiques Belges, 1994, vol. 103, # 5-6, p. 201 - 206
[3] Journal of the Chemical Society - Perkin Transactions 1, 1998, # 22, p. 3767 - 3775
[4] European Journal of Organic Chemistry, 2002, # 19, p. 3304 - 3314
[5] Tetrahedron, 2008, vol. 64, # 42, p. 9992 - 9998

Methyl L-prolinate hydrochloride synthesis

67-56-1
15761-39-4
2133-40-6
Synthesis of Methyl L-prolinate hydrochloride from Methanol and BOC-L-Proline

Methyl L-prolinate hydrochloride Preparation Products And Raw materials

Raw materials

Boc-L-Proline-methyl ester methyl L-prolinate N-Carbobenzyloxy-L-proline methyl ester BOC-L-Proline Methanol
L-Proline

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Preparation Products

Methyl (2S)-1-(Prop-2-yn-1-yl)pyrrolidine-2-carboxylate MFCD16618466 2H-Pyrrole-5-carboxylic acid, 3,4-dihydro-, methyl ester (9CI) H-Ser-Pro-OH L-Prolinamide

Methyl L-prolinate hydrochloride Suppliers

Global Suppliers ( 537)
Supplier Tel Email Country ProdList Advantage
Hubei Hengluyuan Technology co.ltd 027-88188016 18717196322 1764683941@qq.com China 5943 58
Wuhan Mayue Longteng Technology Development Co., Ltd. 132-37125928 15171477138 2428374547@qq.com China 52 58
Changzhou Xiaqing Technological Co., Ltd. 88783621 15961106108 john.chiang@xialichem.com China 143 70
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Supplier Advantage
Hubei Hengluyuan Technology co.ltd 58
Wuhan Mayue Longteng Technology Development Co., Ltd. 58
Changzhou Xiaqing Technological Co., Ltd. 70
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
GL Biochem (Shanghai) Ltd 64

View Latest Price from Methyl L-prolinate hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl L-prolinate hydrochloride pictures 2026-09-18 Methyl L-prolinate hydrochloride
2133-40-6
 100g 98.5%min 100kgs WUHAN FORTUNA CHEMICAL CO., LTD
L-Pro-Ome.HCl pictures 2026-09-17 L-Pro-Ome.HCl
2133-40-6
 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
Methyl L-prolinate hydrochloride pictures 2025-04-04 Methyl L-prolinate hydrochloride
2133-40-6
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

Methyl L-prolinate hydrochloride Spectrum

Methyl L-prolinate hydrochloride(2133-40-6)1HNMRMethyl L-prolinate hydrochloride(2133-40-6)IRMethyl L-prolinate hydrochloride(2133-40-6)Raman

2133-40-6 (Methyl L-prolinate hydrochloride) Related Search:

tert-Butyl L-prolinate hydrochloride L-Alanine methyl ester hydrochloride Topotecan hydrochloride cis-4-Hydroxy-L-proline Methylparaben
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L-Proline-(4-3H(n)) H-Pro-OtBu Methyl tert-butyl 5-oxo-L-prolinate Ethyl L-serinate hydrochloride
2-Pyrrolidinecarbonitrile,1-acetyl-,(2S)-(9CI) H-Pro-Hyp-OH H-Ser-Gly-OH

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(S)-Pyrrolidine-2-carboxylic acid methyl ester hydrochloride L-Proline methyl ester hydrochloride≥ 99% (HPLC) Methyl L-prolite hydrochloride L-Proline methyleester hydrochloride H-L-PRO-OME HCL H-PRO-OME HCL L-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER HCL L-PROLINE METHYL ESTER HYDROCHLORIDE SALT METHYL L-PROLINATE HYDROCHLORIDE PROLINE-OME HCL L-Proline Methyl Ester HCl PAPAIN SUSPENSION IN 0.05 M SODIUM*ACETA TE L-PROLINE METHYL ESTER HYDROCHLORIDE, 9& L-Pro-OMe·HCl, 98% (2S)-2-(Methoxycarbonyl)pyrrolidin-1-ium chloride L-Proline methyl ester hydrochloride 98% H-Pro-OMe·HCl(Solid) ine methyL Methyl pyrrolidine-2-carboxylate hydrochloride 97% METHYL 2-PYRROLIDINE CARBOXYLATE HYDROCHLORIDE L-PRALINE METHYLESTER HYDROCHLORIDE PROLINE METHYL ESTER HYDROCHLORIDE Proline, Methyl ester, HCl L-Proline methyl ester hydrochloride, 98+% L-Sroline methyl ester hydrochloride, 98% (2S)-Pyrrolidine-2-carboxylic acid methyl·hydrochloric acid (2S)-Pyrrolidine-2-carboxylic acid methyl·hydrochloride L-Proline methyl·hydrochloric acid L-Pro-OMe·Hydrochloride Proline methyl·hydrochloride L-Prolin Methyl Ester Hydrochloride methyl－prolinatehydrochloride (2S)-Methyl pyrrolidine-2-carboxylate hydrochloride 98% L-Proline methyl est L-Proline methyl ester hydrochloride, Methyl L-prolinate hydrochloride L-Proline Methyl ester hydrochloride, 98% 1GR L-Proline Methyl Ester Monohydrochloride Methyl Proline Hydrochloride 2-pyrrolidinecarboxylic acid methyl ester hydrochloride (2S)-Methyl pyrrolidine-2-carboxylate hydrochloride L-ProlineMethylEsterHydrochloride> 2133-40-6 (L-PROLINE METHYL ESTER HYDROCHLORIDE) Methyl L-prolinate hydrochloride USP/EP/BP L-Proline, methyl ester, hydrochloride (1:1) H-Pro-OMel.HCl L-Proline methyl ester hydrochloride L-proline methyl ester hydrochloride, 98.5%min methyl (2S)-pyrrolidine-2-carboxylate hydrochloride - [M22329] L-PROLINE METHYL ESTER HYDROCHLORIDE L-Pro-Ome.HCl Methyl (2S)-pyrrolidine-2-carboxylate hydrochloride PRO-OME.HCL 2133-40-6 C6H11NO2ClH Peptide Synthesis Specialty Synthesis Amino Acid Derivatives Proline [Pro, P]