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Methyl L-prolinate hydrochloride

Methyl L-prolinate hydrochloride Structure
Methyl L-prolinate hydrochloride structure
CAS No.
2133-40-6
Chemical Name:
Methyl L-prolinate hydrochloride
Synonyms
L-PROLINE METHYL ESTER HYDROCHLORIDE;PROLINE METHYL ESTER HYDROCHLORIDE;L-Proline Methyl Ester Monohydrochloride;L-Proline methyleester hydrochloride;Methyl L-prolinate hydrochloride USP/EP/BP;L-Proline methyl ester hydrochloride≥ 99% (HPLC);ine methyL;H-PRO-OME HCL;L-Pro-Ome.HCl;H-Pro-OMel.HCl
CBNumber:
CB3116045
Molecular Formula:
C6H12ClNO2
Molecular Weight:
165.62
MDL Number:
MFCD00012708
MOL File:
2133-40-6.mol
MSDS File:
SDS
Last updated:2026-01-13 11:19:06
Product description Number Pack Size Price
L-Proline methyl ester hydrochloride 98% 287067 1g $40
L-Proline methyl ester hydrochloride 98% 287067 5g $111
L-Proline Methyl Ester Hydrochloride >98.0%(N) P0342 5g $49
L-Proline Methyl Ester Hydrochloride >98.0%(N) P0342 25g $180
L-Proline methyl ester hydrochloride 98% 287067 25g $140
More product size
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Methyl L-prolinate hydrochloride Properties

Melting point 69-71 °C(lit.)
alpha -33 º (c=1, H2O)
Boiling point 55 °C / 11mmHg
Density 1.1426 (rough estimate)
refractive index -31.5 ° (C=1, H2O)
storage temp. Inert atmosphere,2-8°C
solubility Chloroform, Methanol (Slightly), Water (slightly)
form Crystalline Powder, Crystals, and/or Chunks
color White
optical activity [α]20/D 31°, c = 0.5 in H2O
Sensitive Hygroscopic
BRN 3596045
Stability Hygroscopic
Major Application peptide synthesis
InChI 1S/C6H11NO2.ClH/c1-9-6(8)5-3-2-4-7-5;/h5,7H,2-4H2,1H3;1H/t5-;/m0./s1
InChIKey HQEIPVHJHZTMDP-JEDNCBNOSA-N
SMILES Cl[H].[H][C@]1(CCCN1)C(=O)OC
CAS DataBase Reference 2133-40-6(CAS DataBase Reference)
FDA UNII 7LWL7P890M
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26-37/39
WGK Germany  3
F  3-8-10-21
Hazard Note  Harmful
HS Code  29189900
Storage Class 11 - Combustible Solids
NFPA 704
1
2 1

Methyl L-prolinate hydrochloride price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 287067 L-Proline methyl ester hydrochloride 98% 2133-40-6 1g $40 2026-03-19 Buy
Sigma-Aldrich 287067 L-Proline methyl ester hydrochloride 98% 2133-40-6 5g $111 2026-03-19 Buy
TCI Chemical P0342 L-Proline Methyl Ester Hydrochloride >98.0%(N) 2133-40-6 5g $49 2026-03-19 Buy
TCI Chemical P0342 L-Proline Methyl Ester Hydrochloride >98.0%(N) 2133-40-6 25g $180 2026-03-19 Buy
Sigma-Aldrich 287067 L-Proline methyl ester hydrochloride 98% 2133-40-6 25g $140 2026-03-19 Buy
Product number Packaging Price Buy
287067 1g $40 Buy
287067 5g $111 Buy
P0342 5g $49 Buy
P0342 25g $180 Buy
287067 25g $140 Buy

Methyl L-prolinate hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Crystalline

Uses

L-Proline Methyl Ester Hydrochloride (cas# 2133-40-6) is a compound useful in organic synthesis.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Methanol

67-56-1

L-Proline

147-85-3

Methyl L-prolinate hydrochloride

2133-40-6

The general procedure for the synthesis of L-proline methyl ester hydrochloride from methanol and L-proline was as follows: first, methyl (S)-pyrrolidine-2-carboxylate was prepared by reacting (S)-proline (10.2 g, 88.6 mmol) with SOCl (11.6 g, 7.10 mL, 97.5 mmol) in refluxed methanol (60 mL) for 29 hours. Upon completion of the reaction, excess solvent and SOCl were removed by distillation under reduced pressure to afford the proline ester as a gray oil (15.9 g, quantitative yield). Subsequently, 2-fluoro-1-nitrobenzene (6.92 g, 5.18 mL, 49.0 mmol) was reacted with methyl (S)-pyrrolidine-2-carboxylate (7.55 g, 45.6 mmol) prepared as described above according to the literature method to afford bright yellow crystals of L-prolinylmethyl ester hydrochloride (12.0 g, quantitative yield), which was used without further purification for subsequent The product can be used for subsequent experiments without further purification.

References

[1] Heterocycles, 1986, vol. 24, # 4, p. 1045 - 1060
[2] Bulletin des Societes Chimiques Belges, 1994, vol. 103, # 5-6, p. 201 - 206
[3] Journal of the Chemical Society - Perkin Transactions 1, 1998, # 22, p. 3767 - 3775
[4] European Journal of Organic Chemistry, 2002, # 19, p. 3304 - 3314
[5] Tetrahedron, 2008, vol. 64, # 42, p. 9992 - 9998

Methyl L-prolinate hydrochloride synthesis

67-56-1
15761-39-4
2133-40-6
Synthesis of Methyl L-prolinate hydrochloride from Methanol and BOC-L-Proline

Methyl L-prolinate hydrochloride Preparation Products And Raw materials

Raw materials

Boc-L-Proline-methyl ester methyl L-prolinate N-CARBOBENZYLOXY-L-PROLINE METHYL ESTER BOC-L-Proline Methanol
L-Proline

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Preparation Products

Methyl (2S)-1-(Prop-2-yn-1-yl)pyrrolidine-2-carboxylate MFCD16618466 2H-Pyrrole-5-carboxylic acid, 3,4-dihydro-, methyl ester (9CI) H-SER-PRO-OH L-Prolinamide

Methyl L-prolinate hydrochloride Suppliers

Global( 521)Suppliers
Supplier Tel Email Country ProdList Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd 		+8618382028708 ni@enlaibio.com China 1098 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21592 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29822 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
Shanghai Longyu Biotechnology Co., Ltd. 		+8619521488211 info@longyupharma.com China 2542 58
Supplier Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Accela ChemBio Inc. 		58
Xiamen AmoyChem Co., Ltd 		58
Shanghai Longyu Biotechnology Co., Ltd. 		58

View Lastest Price from Methyl L-prolinate hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl L-prolinate hydrochloride pictures 2026-04-17 Methyl L-prolinate hydrochloride
2133-40-6
 US $0.00 / Kg/Bag 100g 98.5%min 100kgs WUHAN FORTUNA CHEMICAL CO., LTD
L-Pro-Ome.HCl pictures 2026-04-17 L-Pro-Ome.HCl
2133-40-6
 US $0.00-0.00 / kg 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
Methyl L-prolinate hydrochloride pictures 2025-04-04 Methyl L-prolinate hydrochloride
2133-40-6
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
  • L-Pro-Ome.HCl pictures
  • L-Pro-Ome.HCl
    2133-40-6
  • US $0.00-0.00 / kg
  • 98%
  • Sichuan HongRi Pharma-Tech Co.,Ltd

Methyl L-prolinate hydrochloride Spectrum

Methyl L-prolinate hydrochloride(2133-40-6)1HNMRMethyl L-prolinate hydrochloride(2133-40-6)IRMethyl L-prolinate hydrochloride(2133-40-6)Raman

2133-40-6(Methyl L-prolinate hydrochloride)Related Search:

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H-PRO-OTBU Thiophanate-methyl Methyl H-PRO-HYP-OH tert-butyl 5-oxo-L-prolinate
H-SER-GLY-OH Ethyl L-serinate hydrochloride 2-Pyrrolidinecarbonitrile,1-acetyl-,(2S)-(9CI)

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(S)-Pyrrolidine-2-carboxylic acid methyl ester hydrochloride L-Proline methyl ester hydrochloride≥ 99% (HPLC) Methyl L-prolite hydrochloride L-Proline methyleester hydrochloride H-L-PRO-OME HCL H-PRO-OME HCL L-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER HCL L-PROLINE METHYL ESTER HYDROCHLORIDE L-PROLINE METHYL ESTER HYDROCHLORIDE SALT METHYL L-PROLINATE HYDROCHLORIDE PROLINE-OME HCL L-Proline Methyl Ester HCl PAPAIN SUSPENSION IN 0.05 M SODIUM*ACETA TE L-PROLINE METHYL ESTER HYDROCHLORIDE, 9& L-Pro-OMe·HCl, 98% (2S)-2-(Methoxycarbonyl)pyrrolidin-1-ium chloride L-Proline methyl ester hydrochloride 98% H-Pro-OMe·HCl(Solid) ine methyL Methyl pyrrolidine-2-carboxylate hydrochloride 97% METHYL 2-PYRROLIDINE CARBOXYLATE HYDROCHLORIDE L-PRALINE METHYLESTER HYDROCHLORIDE PROLINE METHYL ESTER HYDROCHLORIDE Proline, Methyl ester, HCl L-Proline methyl ester hydrochloride, 98+% L-Sroline methyl ester hydrochloride, 98% (2S)-Pyrrolidine-2-carboxylic acid methyl·hydrochloric acid (2S)-Pyrrolidine-2-carboxylic acid methyl·hydrochloride L-Proline methyl·hydrochloric acid L-Pro-OMe·Hydrochloride Proline methyl·hydrochloride L-Prolin Methyl Ester Hydrochloride methyl－prolinatehydrochloride (2S)-Methyl pyrrolidine-2-carboxylate hydrochloride 98% L-Proline methyl est L-Proline methyl ester hydrochloride, Methyl L-prolinate hydrochloride Methyl (2S)-pyrrolidine-2-carboxylate hydrochloride L-Proline Methyl ester hydrochloride, 98% 1GR L-Proline Methyl Ester Monohydrochloride Methyl Proline Hydrochloride 2-pyrrolidinecarboxylic acid methyl ester hydrochloride (2S)-Methyl pyrrolidine-2-carboxylate hydrochloride L-ProlineMethylEsterHydrochloride> 2133-40-6 (L-PROLINE METHYL ESTER HYDROCHLORIDE) Methyl L-prolinate hydrochloride USP/EP/BP L-Proline, methyl ester, hydrochloride (1:1) H-Pro-OMel.HCl L-Proline methyl ester hydrochloride L-proline methyl ester hydrochloride, 98.5%min methyl (2S)-pyrrolidine-2-carboxylate hydrochloride - [M22329] L-Pro-Ome.HCl 2133-40-6 C6H11NO2ClH Peptide Synthesis Specialty Synthesis Amino Acid Derivatives Proline [Pro, P] Amino Acids and Derivatives