1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)
- CAS No.
- 288148-34-5
- Chemical Name:
- 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)
- Synonyms
- EOS-61290;1-methyl-(9CI);Relacorilant Impurity 2;1-methylpyrazole-4-sulfonyl chloride;1-methyl-4-pyrazolesulfonyl chloride;1-Methyl-1H-pyrazol-4-sulfonyl chloride;4-(Chlorosulphonyl)-1-methyl-1H-pyrazole;1-Methyl-1H-pyrazole-4-sulphonyl chloride;1H-pyrazole-4-sulfonyl chloride, 1-methyl-;1-Methyl-1H-pyrazole-4-sulfonylchloride,97%
- CBNumber:
- CB61297490
- Molecular Formula:
- C4H5ClN2O2S
- Molecular Weight:
- 180.61
- MDL Number:
- MFCD04968667
- MOL File:
- 288148-34-5.mol
- MSDS File:
- SDS
| Boiling point | 295.7±13.0 °C(Predicted) |
|---|---|
| Density | 1.60±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | crystalline solid |
| pka | -3.33±0.10(Predicted) |
| color | White |
| Sensitive | Moisture Sensitive |
| InChI | InChI=1S/C4H5ClN2O2S/c1-7-3-4(2-6-7)10(5,8)9/h2-3H,1H3 |
| InChIKey | RDAVKKQKMLINOH-UHFFFAOYSA-N |
| SMILES | N1(C)C=C(S(Cl)(=O)=O)C=N1 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317 | |||||||||
| Precautionary statements | P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 43 | |||||||||
| Safety Statements | 36/37 | |||||||||
| RIDADR | UN3265 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 2933199090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Skin Sens. 1 | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CBR01513 | 1H-Pyrazole-4-sulfonyl chloride Aldrich | 288148-34-5 | 1g | $391 | 2024-03-01 | Buy |
| Usbiological | 284767 | 1-Methyl-1H-pyrazole-4-sulfonyl chloride Asreported | 288148-34-5 | 1g | $333 | 2026-06-03 | Buy |
| Usbiological | 284767 | 1-Methyl-1H-pyrazole-4-sulfonyl chloride Asreported | 288148-34-5 | 2g | $460 | 2026-06-03 | Buy |
| Usbiological | 284767 | 1-Methyl-1H-pyrazole-4-sulfonyl chloride Asreported | 288148-34-5 | 5g | $686 | 2026-06-03 | Buy |
| Usbiological | 284767 | 1-Methyl-1H-pyrazole-4-sulfonyl chloride Asreported | 288148-34-5 | 10g | $955 | 2026-06-03 | Buy |
1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) Chemical Properties, Uses, Production
Uses
1-Methyl-1H-pyrazole-4-sulfonyl Chloride is used as a reagent in the preparation of benzoindazoles as glucocorticoid receptor modulators.
Synthesis
930-36-9
288148-34-5
1-Methyl-1H-pyrazole (100 g, 1.18 mol) was slowly added dropwise to chlorosulfonic acid (325 mL, 4.84 mol) at 0 °C and under nitrogen protection, keeping stirring. The reaction mixture was then heated to reflux at 110 °C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and quenched by careful pouring into crushed ice with continuous stirring. The precipitated white solid product was collected by vacuum filtration and washed well with cold water. Finally, the product was dried under vacuum to afford 1-methyl-1H-pyrazole-4-sulfonyl chloride (72.2 g, 33% yield), which can be used in subsequent reactions without further purification.
References
[1] Patent: WO2009/29439, 2009, A1. Location in patent: Page/Page column 24
[2] Patent: US6103708, 2000, A
[3] Patent: WO2005/97162, 2005, A2. Location in patent: Page/Page column 432
1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Jingfu Biotechnology Co., LTD | 0598-5859955 13313739955 | sales@jingfubio.com | China | 30 | 58 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 28-83379370 13880556291 | tcy@tcypharm.com | China | 509 | 57 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 |
View Latest Price from 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)
288148-34-5
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-05-07 | 1-methyl-1H-pyrazole-4-sulfonyl chloride
288148-34-5
|
0.98 | 1 tons | Suzhou Nordica Biopharma CO.,LTD | |||
 |
2019-07-06 | 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)
288148-34-5
|
$1.00 | 1G | 98% | 100KG | Career Henan Chemical Co |
-
- 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)
288148-34-5
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-methyl-1H-pyrazole-4-sulfonyl chloride
288148-34-5
- 0.98
- Suzhou Nordica Biopharma CO.,LTD
-
- 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)
288148-34-5
- $1.00
- 98%
- Career Henan Chemical Co
