5-Pyrazolecarboxylic acid
- CAS No.
- 1621-91-6
- Chemical Name:
- 5-Pyrazolecarboxylic acid
- Synonyms
- 1H-PYRAZOLE-3-CARBOXYLIC ACID;PYRAZOLE-3-CARBOXYLIC ACID;Pyrazole-5-carboxylic acid;SKL261;AKOS B000140;AKOS BB-9039;01H-Pyrazole;3- pyrazol formate;ART-CHEM-BB B000140;TIMTEC-BB SBB000005
- CBNumber:
- CB6317652
- Molecular Formula:
- C4H4N2O2
- Molecular Weight:
- 112.09
- MDL Number:
- MFCD00077436
- MOL File:
- 1621-91-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 211°C |
|---|---|
| Boiling point | 417.1±18.0 °C(Predicted) |
| Density | 1.524±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 3.98±0.10(Predicted) |
| form | Powder |
| color | White |
| λmax | 260nm(MeOH)(lit.) |
| InChI | InChI=1S/C4H4N2O2/c7-4(8)3-1-2-5-6-3/h1-2H,(H,5,6)(H,7,8) |
| InChIKey | KOPFEFZSAMLEHK-UHFFFAOYSA-N |
| SMILES | N1C=CC(C(O)=O)=N1 |
| CAS DataBase Reference | 1621-91-6(CAS DataBase Reference) |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P332+P313-P362+P364 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 38 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29331990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Skin Irrit. 2 | |||||||||
| NFPA 704 |
|
5-Pyrazolecarboxylic acid price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 707384 | 1H-Pyrazole-3-carboxylic acid 97% | 1621-91-6 | 1g | $41.8 | 2026-04-30 | Buy |
| TCI Chemical | P1862 | Pyrazole-3-carboxylic Acid >98.0%(HPLC) | 1621-91-6 | 1g | $17 | 2026-04-30 | Buy |
| TCI Chemical | P1862 | Pyrazole-3-carboxylic Acid >98.0%(HPLC) | 1621-91-6 | 5g | $71 | 2026-04-30 | Buy |
| AstaTech | CL3512 | PYRAZOLE-3-CARBOXYLIC ACID 97% | 1621-91-6 | 25G | $27 | 2026-04-30 | Buy |
| AstaTech | CL3512 | PYRAZOLE-3-CARBOXYLIC ACID 97% | 1621-91-6 | 100G | $77 | 2026-04-30 | Buy |
5-Pyrazolecarboxylic acid Chemical Properties,Uses,Production
Chemical Properties
White to light brown powder
Uses
1H-pyrazole-3-carboxylic Acid is a histone lysine demethylase KDM4C and proline racemase inhibitor.
Synthesis
1453-58-3
1621-91-6
The general procedure for the synthesis of pyrazole-3-carboxylic acid from 3-methylpyrazole was as follows: an aqueous solution of potassium permanganate (KMnO4, 40.9 g, 0.26 mol) was slowly added to a stirring solution of 3-methyl-1H-pyrazole (9.8 mL, 0.12 mol) dissolved in 0.5 L of water. The reaction mixture was heated to reflux and maintained for 5 hours. After completion of the reaction, the black suspension was cooled and filtered. The filtrate was concentrated to a smaller volume and acidified with 3 N hydrochloric acid (HCl). Subsequently, the precipitated white solid product was collected and washed with ethyl ether (Et2O) to give the final pyrazole-3-carboxylic acid in 100% yield.
References
[1] Journal of the American Chemical Society, 2000, vol. 122, # 44, p. 10810 - 10820
[2] Patent: WO2004/80999, 2004, A1. Location in patent: Page 43
[3] Russian Journal of Physical Chemistry, 1992, vol. 66, # 4, p. 463 - 465
[4] Zhurnal Fizicheskoi Khimii, 1992, vol. 66, # 4, p. 871 - 874
[5] Organic Mass Spectrometry, 1982, vol. 17, # 7, p. 299 - 303
5-Pyrazolecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Liheng Biotechnology Co., Ltd. | 0531-18763987518 18763987518 | levi@lihengpharm.com | China | 1760 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Yangzhou Siyu Chemical Co.,Ltd. | 0514-87325867 | sales@siyuchem.com | China | 370 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Lastest Price from 5-Pyrazolecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-02 | 5-Pyrazolecarboxylic acid
1621-91-6
|
$6.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 5-Pyrazolecarboxylic acid
1621-91-6
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | 5-Pyrazolecarboxylic Acid
1621-91-6
|
$10.70 | 10kg | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 5-Pyrazolecarboxylic acid
1621-91-6
- $6.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 5-Pyrazolecarboxylic acid
1621-91-6
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 5-Pyrazolecarboxylic Acid
1621-91-6
- $10.70
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
