Dextromethorphan hydrobromide monohydrate
- CAS No.
- 6700-34-1
- Chemical Name:
- Dextromethorphan hydrobromide monohydrate
- Synonyms
- Dextromethorphan HBr monohydrate;DextroMethorphan hydrobroMide hydrate;dextromethorphansigmareference*standard;Dextromethorphan Hydrobromide dextrorotation;(9S,13S,14S)-3-METHOXY-17-METHYLMORPHINAN HYDROBROMIDE, D-3-METHOXY-N-METHYLMORPHINAN HYDROBROMIDE MONOHYDRATE;DMHM;Dextromethorphan hyd;DEXTROMETHORPHAN HBr IP;Morphinan,3-methoxy-17-methyl-;Dextromethorphani Hydrobromidum
- CBNumber:
- CB6131946
- Molecular Formula:
- C18H28BrNO2
- Molecular Weight:
- 370.33
- MDL Number:
- MFCD02173901
- MOL File:
- 6700-34-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 116-119°C |
|---|---|
| alpha | [α]D25 +26～+30° (c=1.85, H2O) |
| Flash point | 11 °C |
| storage temp. | Store at RT |
| solubility | Sparingly soluble in water, freely soluble in ethanol (96 per cent). |
| form | solid |
| color | White to Off-White |
| PH | pH (10g/l, 25℃) : 5.2～6.5 |
| BRN | 6453793 |
| InChI | InChI=1/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/s3 |
| InChIKey | QYPSYPPSHXDFLV-UHFFFAOYSA-N |
| SMILES | O(C1C=CC2C[C@]3([H])N(C)CC[C@]4(CCCC[C@@]43[H])C=2C=1)C.Br.O |&1:6,12,17,r| |
| LogP | 1.351 (est) |
| CAS DataBase Reference | 6700-34-1(CAS DataBase Reference) |
| FDA UNII | 9D2RTI9KYH |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H411 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P310-P391-P405 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25 | |||||||||
| Safety Statements | 7-16-36/37-45 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 3822000002 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Chronic 2 |
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| NFPA 704 |
|
Dextromethorphan hydrobromide monohydrate price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR1018 | Dextromethorphan HBr certified reference material, pharmaceutical secondary standard | 6700-34-1 | 10 g | $566 | 2026-04-30 | Buy |
| Sigma-Aldrich | D2531 | Dextromethorphan hydrobromide monohydrate ≥99% (TLC) | 6700-34-1 | 5g | $93.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | D0740000 | Dextromethorphan hydrobromide European Pharmacopoeia (EP) Reference Standard | 6700-34-1 | 100 mg | $221 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1181007 | Dextromethorphan hydrobromide United States Pharmacopeia (USP) Reference Standard | 6700-34-1 | 500mg | $455 | 2026-04-30 | Buy |
| Sigma-Aldrich | D0740000 | Dextromethorphan hydrobromide European Pharmacopoeia (EP) Reference Standard | 6700-34-1 | D0740000 | $168 | 2024-03-01 | Buy |
Dextromethorphan hydrobromide monohydrate Chemical Properties, Uses, Production
Description
Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant. However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-
Chemical Properties
White Solid
Uses
An antitussive drug. Orally active synthetic morphine analog. Analgesic (narcotic). Racemethorphan and levomethorpham are controlled substances (opiates).
Uses
Antitussive;Opioid ligand
Definition
ChEBI: Dextromethorphan hydrobromide is the hydrobromide and monohydrate of the antitussive drug dextromethorphan. It is a hydrate and a hydrobromide. It contains a dextromethorphan.
brand name
Benylin DM (Parke-Davis); Dextromethorphan Hydrobromide OROS Tablets (Ciba-Geigy); Drixoral Cough (Schering-Plough HealthCare); PediaCare 1 (McNeil Consumer); Romilar (Hoffmann-LaRoche-International); St. Joseph Cough Syrup (Schering-Plough HealthCare).
Biological Activity
Non-competitive, low affinity NMDA receptor antagonist. Antitussive, anticonvulsive and neuroprotective agent.
Toxics Screening Level
The Initial Threshold Screening Level (ITSL) is 0.4 μg/m3 annual average.
References
[1] DONALD C. BOLSER. Antitussive effects of GABAB agonists in the cat and guinea-pig[J]. British Journal of Pharmacology, 1993, 110 1: 491-495. DOI: 10.1111/j.1476-5381.1993.tb13837.x
[2] HASSAN JAMALI Azhdar H. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice[J]. Neuroscience Letters, 2020, 729: Article 134988. DOI: 10.1016/j.neulet.2020.134988
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[4] CHULATHIDA CHOMCHAI Boonying M. Stimulant methamphetamine and dextromethorphan use among Thai adolescents: implications for health of women and children.[J]. Journal of Medical Toxicology, 2012: 291-294. DOI: 10.1007/s13181-012-0228-0
Dextromethorphan hydrobromide monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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