C 1311
- CAS No.
- 138154-39-9
- Chemical Name:
- C 1311
- Synonyms
- C 1311;Symadex;XLS-002;Symadex >=98% (HPLC);CUNDRHORZHFPLY-UHFFFAOYSA-N;5-((2-(Diethylamino)ethyl)amino)-8-hydroxy-6H-imidazo[4,5,1-de]acridin-6-one;6H-Imidazo[4,5,1-de]acridin-6-one, 5-[[2-(diethylamino)ethyl]amino]-8-hydroxy-
- CBNumber:
- CB61382587
- Molecular Formula:
- C20H22N4O2
- Molecular Weight:
- 350.41
- MDL Number:
- MFCD00947296
- MOL File:
- 138154-39-9.mol
| Product description | Number | Pack Size | Price |
| Symadex ≥98% (HPLC) | SML0465 | 5mg | $143 |
| Symadex ≥98% (HPLC) | SML0465 | 25mg | $390 |
| C-1311 95.00% | KIN0000064 | 5MG | $498.53 |
| Boiling point | 605.8±65.0 °C(Predicted) |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL (clear solution; warmed) |
| pka | 8.35±0.20(Predicted) |
| form | powder |
| color | white to beige |
| FDA UNII | MZ4Y5H4OAB |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
C 1311 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0465 | Symadex ≥98% (HPLC) | 138154-39-9 | 5mg | $143 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML0465 | Symadex ≥98% (HPLC) | 138154-39-9 | 25mg | $390 | 2025-07-31 | Buy |
| American Custom Chemicals Corporation | KIN0000064 | C-1311 95.00% | 138154-39-9 | 5MG | $498.53 | 2021-12-16 | Buy |
C 1311 Chemical Properties,Uses,Production
Uses
C-1311 shows to inhibit the catalytic activity of DNA topoisomerase II in vitro and in tumour cells. C-1311 prolongs G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe[1].
Biological Activity
Symadex is an FMS-like tyrosine kinase 3 (FLT3) and topoisomerase-II inhibitor; ABCG2 substrate; cell cycle modulator.
References
[1] Magdalena Hyzy, et al. Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells. Biochem Pharmacol. 2005 Mar 1;69(5):801-9. DOI:10.1016/j.bcp.2004.11.028
C 1311 Preparation Products And Raw materials
Raw materials
Preparation Products
C 1311 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49976 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20033 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Supplier | Advantage |
|---|---|
| CONIER CHEM AND PHARMA LIMITED | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | 58 |
| Energy Chemical | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 58 |
| Merck KGaA | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 58 |
