DL-Propargylglycine
- CAS No.
- 64165-64-6
- Chemical Name:
- DL-Propargylglycine
- Synonyms
- NSC21940;DL-Pra-OH;H-DL-PRA-OH;H-DL-Prg-OH;DL-PROPARGYL-GLY-OH;DL-Propargylglycine;DL-Gly(Propargyl)-OH;H-PROPARGYL-DL-GLY-OH;H-DL-GLY(PROPARGYL)-OH;H-PROPARGYL-DL-GLYCINE
- CBNumber:
- CB6140609
- Molecular Formula:
- C5H7NO2
- Molecular Weight:
- 113.11
- MDL Number:
- MFCD00056728
- MOL File:
- 64165-64-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | -20°C |
|---|---|
| solubility | Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml). |
| form | Crystalline Powder |
| color | White to off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
| Major Application | cell analysis |
| InChI | InChI=1S/C5H7NO2/c1-2-3-4(6)5(7)8/h1,4H,3,6H2,(H,7,8) |
| InChIKey | DGYHPLMPMRKMPD-UHFFFAOYSA-N |
| SMILES | C(N)(C(=O)O)CC#C |
| FDA UNII | FU67PLJ48R |
| UNSPSC Code | 12352209 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
DL-Propargylglycine price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P7888 | DL-Propargylglycine cystathionine γ-lyase inhibitor | 64165-64-6 | 1g | $256 | 2026-04-30 | Buy |
| Sigma-Aldrich | P7888 | DL-Propargylglycine cystathionine γ-lyase inhibitor | 64165-64-6 | 5g | $938 | 2026-04-30 | Buy |
| Usbiological | 287837 | DL-Propargylglycine Asreported | 64165-64-6 | 500mg | $333 | 2026-06-03 | Buy |
| Usbiological | 287837 | DL-Propargylglycine Asreported | 64165-64-6 | 1g | $529 | 2026-06-03 | Buy |
| Usbiological | 287837 | DL-Propargylglycine Asreported | 64165-64-6 | 2g | $726 | 2026-06-03 | Buy |
DL-Propargylglycine Chemical Properties, Uses, Production
Description
Propargylglycine (64165-64-6) is an irreversible inhibitor of the hydrogen sulfide biosynthesis enzyme, cystathione-γ-lyase. It inhibits H2S production in rat liver preparations (IC50=55 μM) and inhibits the rise in plasma H2S in rats with hemorrhagic shock2. Propargylglycine reduces inflammation in a rodent carrageenan-induced hindpaw edema model3 and ameliorates gentamycin-induced nephrotoxicity1.
Chemical Properties
White to off-white powder
Uses
Dl-propargylglycine is an inhibitor of hydrogen sulfide (H2S) production.
Synthesis Reference(s)
Journal of the American Chemical Society, 76, p. 3484, 1954 DOI: 10.1021/ja01642a036
Tetrahedron Letters, 22, p. 1787, 1981 DOI: 10.1016/S0040-4039(01)90439-3
Biochem/physiol Actions
DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis. Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H2S).
References
[1] VAN P. DAM . Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity[J]. European journal of pharmacology, 2012, 685 1: Pages 165-173. DOI:10.1016/j.ejphar.2012.04.030
[2] YING-YUAN PAMELA MOK. Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis[J]. British Journal of Pharmacology, 2009, 143 7: 881-889. DOI:10.1038/sj.bjp.0706014
[3] MADHAV BHATIA. Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat[J]. British Journal of Pharmacology, 2009, 145 2: 141-144. DOI:10.1038/sj.bjp.0706186
DL-Propargylglycine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shenzhen Sungening Bio-Tech Co., Ltd | +86-0755-89668383 | sales@sungening.com | China | 1319 | 65 |
| Goodee Pharma Co., Ltd. | 0512-62956210 | yongyan@goodeepharma.com | China | 132 | 60 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
View Latest Price from DL-Propargylglycine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | DL-PROPARGYLGLYCINE
64165-64-6
|
$10.00 | 10KG | 99% | 100kg | Career Henan Chemical Co |
-
- DL-PROPARGYLGLYCINE
64165-64-6
- $10.00
- 99%
- Career Henan Chemical Co
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