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LASSBio-2052

LASSBio-2052 structure

CAS No.: 2549160-15-6

Chemical Name:: LASSBio-2052

Synonyms: LASSBio-2052;Benzoic acid, 2-[[(3-hydroxy-4-methoxyphenyl)methyl]amino]-, 2-[[4-(trifluoromethyl)phenyl]methylene]hydrazide

CBNumber:: CB614210473

Molecular Formula:: C23H20F3N3O3

Molecular Weight:: 443.42

MDL Number:

MOL File:: 2549160-15-6.mol

Last updated:2025-05-19 13:47:15

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LASSBio-2052 Properties

Melting point	172-173 °C
Density	1.284±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	9.843±0.10(predicted)

LASSBio-2052 Chemical Properties, Uses, Production

Uses

LASSBio-2052 is a derivative of N-acylhydrazone with antitumor activity against hepatocellular carcinoma (HCC). LASSBio-2052 inhibits HCC cells HepG2 and Hep3B, with IC50 of 18 and 41 μM. LASSBio-2052 arrests the cell cycle at G2/M phase, through downregulation of FOXM1. LASSBio-2052 induces apoptosis in HCC cells[1].

References

[1] Andrade AAR, et al., Antiproliferative Activity of N-Acylhydrazone Derivative on Hepatocellular Carcinoma Cells Involves Transcriptional Regulation of Genes Required for G2/M Transition. Biomedicines. 2024 Apr 18;12(4):892. DOI:10.3390/biomedicines12040892

LASSBio-2052 Preparation Products And Raw materials

Raw materials

Preparation Products

LASSBio-2052 Suppliers

Global Suppliers ( 4)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Beckham Medical Technology Co., Ltd	13816613772	huahero21@sina.com	China	2996	55
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9699	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60

Supplier	Advantage
Shanghai Beckham Medical Technology Co., Ltd	55
Shanghai Chaolan Chemical Technology Center	58
TargetMol Chemicals Inc.	58
ATK CHEMICAL COMPANY LIMITED	60

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LASSBio-2052 Benzoic acid, 2-[[(3-hydroxy-4-methoxyphenyl)methyl]amino]-, 2-[[4-(trifluoromethyl)phenyl]methylene]hydrazide 2549160-15-6