Tilorone dihydrochloride
- CAS No.
- 27591-69-1
- Chemical Name:
- Tilorone dihydrochloride
- Synonyms
- Flu;TILORONE HYDROCHLORIDE;2,7-BIS[2-(DIETHYLAMINO)ETHOXY]-9-FLUORENONE DIHYDROCHLORIDE;Deae-f;nsc-143969;Rmi 10008da;TILORONE 2HCL;Tilorone DiHCl;Tilolone hydrochloride;2,7-Bis-deae-fluorenone
- CBNumber:
- CB6144470
- Molecular Formula:
- C25H36Cl2N2O3
- Molecular Weight:
- 483.47
- MDL Number:
- MFCD00134071
- MOL File:
- 27591-69-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Tilorone dihydrochloride 95% | 220957 | 100mg | $192 |
| Tilorone Dihydrochloride >98.0%(HPLC)(T) | T2836 | 100mg | $88 |
| Tilorone Dihydrochloride >98.0%(HPLC)(T) | T2836 | 1g | $355 |
| Tilorone (hydrochloride) ≥98% | 17868 | 50mg | $41 |
| Tilorone (hydrochloride) ≥98% | 17868 | 100mg | $75 |
| More product size | |||
| Melting point | 230-233 °C(lit.) |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Methanol (Slightly) |
| form | Solid |
| color | Orange |
| Merck | 14,9440 |
| InChI | InChI=1S/C25H34N2O3.2ClH/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19;;/h9-12,17-18H,5-8,13-16H2,1-4H3;2*1H |
| InChIKey | BSVYJQAWONIOOU-UHFFFAOYSA-N |
| SMILES | C12C=CC(OCCN(CC)CC)=CC=1C(=O)C1C=C(OCCN(CC)CC)C=CC2=1.Cl.Cl |
| CAS DataBase Reference | 27591-69-1(CAS DataBase Reference) |
| FDA UNII | BJ507J4LKY |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335-H351 | |||||||||
| Precautionary statements | P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38-40 | |||||||||
| Safety Statements | 7-22-26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LL9000000 | |||||||||
| HS Code | 2922.39.4500 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Carc. 2 Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Toxicity | LD50 in mice, rats (single dose): 959, 852 mg/kg orally; 145, 244 mg/kg i.p. (Krueger, Mayer) | |||||||||
| NFPA 704 |
|
Tilorone dihydrochloride price More Price(87)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 220957 | Tilorone dihydrochloride 95% | 27591-69-1 | 100mg | $192 | 2026-04-30 | Buy |
| TCI Chemical | T2836 | Tilorone Dihydrochloride >98.0%(HPLC)(T) | 27591-69-1 | 100mg | $88 | 2026-04-30 | Buy |
| TCI Chemical | T2836 | Tilorone Dihydrochloride >98.0%(HPLC)(T) | 27591-69-1 | 1g | $355 | 2026-04-30 | Buy |
| Cayman Chemical | 17868 | Tilorone (hydrochloride) ≥98% | 27591-69-1 | 50mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 17868 | Tilorone (hydrochloride) ≥98% | 27591-69-1 | 100mg | $75 | 2026-04-30 | Buy |
Tilorone dihydrochloride Chemical Properties,Uses,Production
Description
Tilorone is an orally active, antiviral compound that induces interferon production and is reported to have antitumor, anti-inflammatory, and neuroprotective actions. With chronic administration, tilorone induces lysosomal glycosaminoglycan storage, rendering glycosaminoglycans resistant to enzymatic degradation.
Chemical Properties
Orange-yellow crystalline powder
Uses
Tilorone dihydrochloride was used to study the interaction of drugs with synthetic self-complementary DNA by SPR (Surface Plasmon Resonance).
Uses
Tilorone dihydrochloride is an orally active, interferon-inducing antiviral agent.
Definition
ChEBI: Tilorone dihydrochloride is the dihydrochloride salt of tilorone. It is used as an antiviral drug to treat influenza, herpes infection, viral hepatitis, acute respiratory viral infections and SARS. It has a role as an anti-inflammatory agent, an antineoplastic agent, an interferon inducer, a nicotinic acetylcholine receptor agonist and an antiviral drug. It contains a tilorone(2+).
brand name
Tilorone is INN.
General Description
Effect of tilorone dihydrochloride on the changes of transmembrane potential of mitochondrial membranes of the isolated rat hepatocytes has been investigated. Tilorone dihydrochloride is an orally active, interferon-inducing antiviral agent.
Synthesis
27591-97-5
27591-69-1
2 (100 g, 0.47 mol) was mixed with 2-diethylaminoethyl chloride hydrochloride (300 g, 1.74 mol), KOH (225 g, 4.01 mol), water (320 mL), and toluene (1.5 L), and the reaction was carried out at reflux for 24 hours. After completion of the reaction, the emulsion was cooled to room temperature and the organic layer was separated. The organic layer was washed with 3 mol/L aqueous KOH (500 mL) and subsequently concentrated to dryness under vacuum. The residue was dissolved in anhydrous ethanol (420 g) and the pH was adjusted to 3.0 by passing gaseous HCl. The orange product was recrystallized by ethanol, and after filtration and drying, 200 g of tilolone hydrochloride (Compound 1) was obtained in 93% yield. The melting point of the product was 231-233°C (literature value 235-236°C [22]).IR (KBr) spectrum showed characteristic absorption peaks: 2943.3, 2596.5 (CH), 1708.9 (C=O) cm1. ESI-MS (m/z): 411.0 [M+H] , molecular formula CHNO (molecular weight 410.3).1H-NMR (400 MHz, DO) chemical shift δ (ppm): 7.12 (d, J=6.5Hz, 2H), 6.99 (dd, J=6.5,1.6Hz, 2H), 6.89 (d, J=1.6Hz, 2H), 4.39 (t, J=3.6Hz , 4H), 3.68 (t, J=3.6Hz, 4H), 3.42 (q, J=5.6Hz, 8H), 1.44 (t, J=5.8Hz, 12H).
References
[1] Crystal Growth and Design, 2012, vol. 12, # 12, p. 6118 - 6125
[2] Molecules, 2015, vol. 20, # 12, p. 21458 - 21463
Tilorone dihydrochloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Mascot Import & Export Co., Ltd | +86-0519-85010339 +86-13584504415 | info@mascot-ie.com | China | 432 | 58 |
| Shandong Xingshun New Material Co., Ltd. | +86-0519-86461196 | gxx@xingshengtech.com | China | 552 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from Tilorone dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-09 | Tilorone dihydrochloride
27591-69-1
|
1KG | 99%,USP | 500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-05-11 | Tilorone dihydrochloride
27591-69-1
|
$48.00 | 98.00% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-20 | Tilorone dihydrochloride
27591-69-1
|
$48.00 | 98.00% | 10g | TargetMol Chemicals Inc. |
-
- Tilorone dihydrochloride
27591-69-1
- $0.00
- 99%,USP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Tilorone dihydrochloride
27591-69-1
- $48.00
- 98.00%
- TargetMol Chemicals Inc.
-
- Tilorone dihydrochloride
27591-69-1
- $48.00
- 98.00%
- TargetMol Chemicals Inc.
