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2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Structure
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene structure
CAS No.
898566-17-1
Chemical Name:
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
Synonyms
2-(4-Fluorophenyl)-5-(5-iodo-2-Methylbenzyl)thiophene;Canagliflozin INT5;2-(4-Fluorophenyl);2-(4-FLUOROPHENYL)-5-[(5-IODO-2-METHYLPHENYL)METHYL]THIOPHENE 898566-17-1;)-5-(5-iodo-2-methyL;Canagliflozin iMpurity D;Kangglinide Intermediate;-5-(5-iodo-2-methylbenzyl);Canagliflozin Intermediate1;2-(4-Fluorophenyl)-5-(5- iodo-methylphenyI) metl
CBNumber:
CB61463466
Molecular Formula:
C18H14FIS
Molecular Weight:
408.27
MDL Number:
MFCD12405593
MOL File:
898566-17-1.mol
MSDS File:
SDS
Last updated:2026-05-28 01:19:06
Product description Number Pack Size Price
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene TRC-F532295-500MG 500mg $65
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene TRC-F532295-250MG 250mg $59
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene TRC-F532295-1G 1g $90
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene FF34928 5g $900
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene FF34928 2g $900
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2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Properties

Melting point 109-110 °C
Boiling point 450.2±45.0 °C(Predicted)
Density 1.533
vapor pressure 0-0Pa at 20-25℃
storage temp. 2-8°C(protect from light)
solubility DMSO (Sparingly), Methanol (Slightly)
form Solid
color Pale Yellow
InChI InChI=1S/C18H14FIS/c1-12-2-7-16(20)10-14(12)11-17-8-9-18(21-17)13-3-5-15(19)6-4-13/h2-10H,11H2,1H3
InChIKey MGXZKAYHSITHMW-UHFFFAOYSA-N
SMILES C1(C2=CC=C(F)C=C2)SC(CC2=CC(I)=CC=C2C)=CC=1
LogP 7.5 at pH7
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Aquatic Chronic 4
Eye Dam. 1
REACH Registrations Active

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-F532295-500MG 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 898566-17-1 500mg $65 2026-06-03 Buy
TRC TRC-F532295-250MG 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 898566-17-1 250mg $59 2026-06-03 Buy
TRC TRC-F532295-1G 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 898566-17-1 1g $90 2026-06-03 Buy
Biosynth FF34928 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 898566-17-1 5g $900 2026-06-04 Buy
Biosynth FF34928 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 898566-17-1 2g $900 2026-06-04 Buy
Product number Packaging Price Buy
TRC-F532295-500MG 500mg $65 Buy
TRC-F532295-250MG 250mg $59 Buy
TRC-F532295-1G 1g $90 Buy
FF34928 5g $900 Buy
FF34928 2g $900 Buy

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid.

Uses

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene is an antidiabetic agent and a Canagliflozin (C175190) intermediate. Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and a candidate for the treatment of type 2 diabetes and obesity.

Synthesis

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

1030825-20-7

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene

898566-17-1

2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene (100 g; cf. WO 2005/012326) was dissolved in toluene (300 mL) at room temperature and under nitrogen atmosphere. To this solution, sodium iodide (83 g), cuprous(I) iodide (2.64 g), N,N'-dimethylethylenediamine (2.94 mL) and diethylene glycol dimethyl ether (50 mL) were added sequentially. The reaction mixture was heated to reflux temperature and stirred continuously for 36 hours. Upon completion of the reaction, ethyl acetate (300 mL) was added to the mixture at 40 °C and filtered through a filter pre-coated with activated carbon. The filtrate was washed and concentrated. The resulting residue was suspended in methanol (426 mL) at reflux temperature for 75 minutes. Subsequently, the suspension was cooled to 25 °C and stirring was continued for 1 hour. The precipitate was collected by filtration, washed with methanol and dried under vacuum at 50 °C to afford 2-(5-iodo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene (94.9 g) in white crystalline form. The mass spectrum (APCI) showed a m/z of 409 (M + H); the melting point was 109-110°C. The crystal was found to have the following properties.

References

[1] Patent: WO2009/35969, 2009, A1. Location in patent: Page/Page column 77
[2] Patent: US2010/99883, 2010, A1. Location in patent: Page/Page column 43
[3] Patent: US2016/228375, 2016, A1. Location in patent: Paragraph 0097; 0098

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene synthesis

1030825-20-7
898566-17-1
Synthesis of 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene from 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Preparation Products And Raw materials

Raw materials

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Sodium iodide Copper(l) iodide N,N'-Dimethyl-1,2-ethanediamine Toluene
Diglyme

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Preparation Products

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Suppliers

Global( 356)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20111 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14035 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21533 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Zhejiang ZETian Fine Chemicals Co. LTD 		18957127338 stella@zetchem.com China 2993 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2945 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
Shanghai Rochi Pharmaceutical Co.,Ltd. 		21-38751876 +8615000076078 info@rochipharma.com China 504 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14301 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Jinan Finer Chemical Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shanghai Rochi Pharmaceutical Co.,Ltd. 		58
Win-Win chemical CO., Limited 		58

View Lastest Price from 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene pictures 2026-08-31 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
898566-17-1
 0.99 RongNa Biotechnology Co.,Ltd
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene pictures 2026-08-26 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
898566-17-1
 $5.00 1KG 99% Henan Fengda Chemical Co., Ltd
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene pictures 2026-08-21 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
898566-17-1
 $60.00-100.00 100kg 99.99% 100Tons Hebei Dangtong Import and export Co LTD

898566-17-1(2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)Related Search:

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Thiophene, 2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]- 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Canagliflozin iMpurity D 2-((5-IODO-2-METHYLPHENYL)METHYL)-5-(4-FLUOROPHENYL)THIOPHENE Canagliflozin Intermediate1 2-(4-Fluorophenyl) -5-(5-iodo-2-methylbenzyl) 2-(4-Flurophenyl)-5-[(5-Iodo-2-methylphenyl] methyl] Thiophene 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl] )-5-(5-iodo-2-methyL 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene ISO 9001：2015 REACH Canagliflozin intermediates，2-(4-Fluorophenyl)-5-[(5-iodo-2- methylphenyl)methyl]thiophene 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene cas 898566-17-1 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophen... Canagliflozin impurity DQ: What is Canagliflozin impurity D Q: What is the CAS Number of Canagliflozin impurity D Q: What is the storage condition of Canagliflozin impurity D 2-(4-Fluorophenyl)-5-(5-iodo-methylphenyl) methyl] thiophene 2-(4-Fluorophenyl)-5-(5- iodo-methylphenyI) metl 2-(4-Fluoropheny1)-5-[(5-iodo-2 methylphenyl)methyl]thiophene Canagliflozin impurity-(2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene) Kangglinide Intermediate 2-(5-iodo-2-methylbenzyl)-5-(4-fluoro-phe?nyl)thiophene 2-(4-Fluorophenyl)-5-(5-iodo-2-Methylbenzyl)thiophene 2-(4-FLUOROPHENYL)-5-[(5-IODO-2-METHYLPHENYL)METHYL]THIOPHENE 898566-17-1 Canagliflozin INT5 898566-17-1 C18H14FIS C18H14FI 898566-17-1