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BOC-HYP(BZL)-OH

BOC-HYP(BZL)-OH Structure
BOC-HYP(BZL)-OH structure
CAS No.
54631-81-1
Chemical Name:
BOC-HYP(BZL)-OH
Synonyms
BOC-HYP(BZL);BOC-HYP(BZL)-OH;BOC-L-HYP(BZL)-OH;Boc-Hyp(Bzl)·DCHA;BOC-PRO(4-OBZL)-OH;BOC-HYP(BZL)-OH DCHA;Boc-L-Hyp(Bzl)-OH·DCHA;BOC-HYP(BZL)-OH·DCHA,98%;BOC-HYP(BZL)-OH USP/EP/BP;BOC-HYDROXYPROLINE(BZL)-OH
CBNumber:
CB6148544
Molecular Formula:
C17H23NO5
Molecular Weight:
321.37
MDL Number:
MFCD00037325
MOL File:
54631-81-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:39:21
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BOC-HYP(BZL)-OH Properties

Melting point ~70 °C
Boiling point 461.3±45.0 °C(Predicted)
Density 1.21±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form Powder
pka 3.75±0.40(Predicted)
Appearance White to off-white Solid
optical activity [α]20/D 40±2°, c = 2% in ethanol
BRN 5296858
Major Application peptide synthesis
InChI 1S/C17H23NO5/c1-17(2,3)23-16(21)18-10-13(9-14(18)15(19)20)22-11-12-7-5-4-6-8-12/h4-8,13-14H,9-11H2,1-3H3,(H,19,20)/t13-,14+/m1/s1
InChIKey DGIGGVANZFKXLS-KGLIPLIRSA-N
SMILES CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1C(O)=O)OCc2ccccc2
CAS DataBase Reference 54631-81-1(CAS DataBase Reference)
UNSPSC Code 12352200
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 13 - Non Combustible Solids

BOC-HYP(BZL)-OH price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 15535 Boc-Hyp(Bzl)-OH ≥98.0% (HPLC) 54631-81-1 5g $261 2022-05-15 Buy
Usbiological 264602 Boc-O-benzyl-L-trans-4-hydroxyproline Asreported 54631-81-1 2g $360 2026-06-03 Buy
Usbiological 264602 Boc-O-benzyl-L-trans-4-hydroxyproline Asreported 54631-81-1 5g $563 2026-06-03 Buy
Usbiological 264602 Boc-O-benzyl-L-trans-4-hydroxyproline Asreported 54631-81-1 10g $781 2026-06-03 Buy
Usbiological 264602 Boc-O-benzyl-L-trans-4-hydroxyproline Asreported 54631-81-1 25g $1090 2026-06-03 Buy
Product number Packaging Price Buy
15535 5g $261 Buy
264602 2g $360 Buy
264602 5g $563 Buy
264602 10g $781 Buy
264602 25g $1090 Buy

BOC-HYP(BZL)-OH Chemical Properties,Uses,Production

Chemical Properties

White to off-white powder

Uses

Boc-Hyp(Bzl)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

(2S,4R)-1-BOC-4-BENZYLOXY-PYRROLIDINE-2-DICARBOXYLIC ACID METHYL ESTER

136024-60-7

4-Benzyloxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

40350-83-2

General procedure for the synthesis of 4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid from 1-(tert-butyl) 2-methyl (2S,4R)-4-(benzyloxy)pyrrolidine-1,2-dicarboxylic acid ester: lithium hydroxide was added to a mixture of THF and H2O (60 mL, 2:1, v/v/v/v/v) of compound 2 (3.45 g, 10.29 mmol) monohydrate (1.29 g, 30.87 mmol). The reaction mixture was stirred at room temperature for 3 hours. After the completion of the reaction was monitored by TLC, the reaction mixture was concentrated under reduced pressure, acidified to pH < 7 with 1N hydrochloric acid solution and subsequently extracted with ethyl acetate (3 x 30 mL). The organic layers were combined, washed with saturated sodium chloride solution (30 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by grinding with pentane (20 mL) to give compound 3 (3.21 g, 97% yield) in white solid form. Mass spectrum (ESI) m/z 322 [M+H]+.

References

[1] Patent: US9994614, 2018, B2. Location in patent: Page/Page column 51; 52; 53
[2] Patent: WO2012/146666, 2012, A1. Location in patent: Page/Page column 206

BOC-HYP(BZL)-OH Preparation Products And Raw materials

Raw materials

(2S,4R)-1-BOC-4-BENZYLOXY-PYRROLIDINE-2-DICARBOXYLIC ACID METHYL ESTER Tetrahydrofuran Lithium hydroxide monohydrate

Preparation Products

BOC-HYP(BZL)-OH Suppliers

Global( 151)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Energy Chemical 61
GL Biochem (Shanghai) Ltd 64
Capot Chemical Co., Ltd 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Pure Chemistry Scientific Inc. 62
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60
Sichuan Kulinan Technology Co., Ltd 57

View Lastest Price from BOC-HYP(BZL)-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BOC-HYP(BZL)-OH pictures 2019-07-06 BOC-HYP(BZL)-OH
54631-81-1
 $100.00 1KG 99% Career Henan Chemical Co

BOC-HYP(BZL)-OH Spectrum

BOC-HYP(BZL)-OH(54631-81-1)1HNMR

54631-81-1(BOC-HYP(BZL)-OH)Related Search:

H-Arg(Boc)2-pNA Fmoc-L-beta-homoleucine H-Arg(Boc)2-AMC Bis(H-Arg(Boc)2)-rhodaMine 110 BOC-L-BETA-HOMOLEUCINE
L-beta-Homoleucine hydrochloride Boc-Hyp-OEt Z-HOMOARGININE BOC-HOMOARGININE (NO2) L-Hydroxyproline
L-Proline Dicyclohexylamine Fmoc-Hyp(tBu)-OH BOC-HYP(BZL)-OH Fmoc-Hyp(Bzl)-OH
(2S,4R)-Boc-4-(2-naphthylmethoxy)-pyrrolidine-2-carboxylic acid FMOC-L-HYP(BOM)-OH (2S,4R)-1-BOC-4-BENZYLOXY-PYRROLIDINE-2-DICARBOXYLIC ACID METHYL ESTER

1of4

(4R)-1-Boc-4-(phenylmethoxy)-L-proline Boc-Hyp(Bzl)-OH >=98.0% (HPLC) BOC-HYP(BZL)-OH·DCHA,98% Boc-O-benzyl-L-trans-4-hydroxyproline≥ 98% (HPLC) Boc-L-Hyp(Bzl)-OH·DCHA Boc-O-benzyl-L-trans-4-hydroxyproline dicyclohexylammonium salt99% T-BUTYLOXYCARBONYL-O-BENZYL-L-HYDROXYPROLINE 4-hydroxypyrrolidine-1,2-dicarboxylic acid O1-tert-butyl ester O2-(phenylmethyl) ester N-ALPHA-T-BUTOXYCARBONYL-O-BENZYL-L-HYDROXYPROLINE N-ALPHA-T-BUTOXYCARBONYL-O-BENZYL-TRANS-4-HYDROXY-L-PROLINE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-4-O-BENZYL-HYDROXYPROLINE BOC-PRO(4-OBZL)-OH BOC-O-BENZYL-L-4-HYDROXYPROLINE BOC-O-BENZYL-L-4-TRANS-HYDROXYPROLINE BOC-O-BENZYL-L-4-TRANS-HYDROXYPROLINE DICYCLOHEXYLAMMONIUM SALT BOC-O-BENZYL-4-HYDROXY-L-PROLINE(TRANS) BOC-O-BENZYL-4-L-HYDROXYPROLINE DICYCLOHEXYLAMMONIUM SALT BOC-O-BENZYL-L-TRANS-4-HYDROXYPROLINE BOC-O-BENZYL-L-HYDROXYPROLINE BOC-L-HYP(BZL)-OH BOC-HYP(BZL) BOC-HYP(BZL)-OH BOC-HYP(BZL)-OH DCHA BOC-HYDROXYPROLINE(BZL)-OH Boc-O-benzyl-trans-4-hydroxy-L-proline Boc-O-Benzyl-L-Hydroxyproline Dicyclohexylammonium Salt N-ALPHA-T-BUTYLOXYCARBONYL-L-4-O-BENZYL-HYDROXYPROLINE NALPHA-tert-Butoxycarbonyl-O-benzyl-trans-4-hydroxy-L-proline N-alpha-t-Butyloxycarbonyl-4-O-benzyl-trans-L-hydroxyproline (2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (Tert-Butoxy)Carbonyl Hyp(Bzl)-OH 1,2-Pyrrolidinedicarboxylic acid, 4-(phenylmethoxy)-, 1-(1,1-dimethylethyl) ester, (2S,4R)- (2S,4R)-4-(Benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylicaci BOC-HYP(BZL)-OH USP/EP/BP Boc-Hyp(Bzl)·DCHA (2S,4R)-N-Boc-4-(benzyloxy)pyrrolidine-2-carboxylic Acid 54631-81-1 54631-81-8 C29H46N2O5 C17H23NO5C12H23N Specialty Synthesis Proline Derivatives Peptide Synthesis Unnatural Amino Acid Derivatives Hydroxyproline [Hyp] Unusual Amino Acids Boc-Amino acid series Amino Acid Derivatives Amino Acids