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Tetraethylammonium fluoride dihydrate

CAS No.
665-46-3
Chemical Name:
Tetraethylammonium fluoride dihydrate
Synonyms
TETRAETHYLAMMONIUM FLUORIDE;[E4N]F;Tetraethylazanium fluoride;Tetraethylaminium·fluoride;TetraethylaMMoniuM Fluoride N,N,N-TRIETHYL-ETHANAMINIUFLUORIDE;N,N,N-Triethylethanaminium·fluoride;Tetraethylammonium fluoride dihydrate;Tetraethylammonium fluoride 2-hydrate;Tetraethylammonium Fluoride Hydrate>
CBNumber:
CB6148887
Molecular Formula:
C8H24FNO2
Molecular Weight:
185.28
MDL Number:
MFCD00011826
MOL File:
665-46-3.mol
Last updated:2025-07-24 18:13:48

Tetraethylammonium fluoride dihydrate Properties

Melting point 80 °C (decomp)
storage temp. Inert atmosphere,Room Temperature
InChI InChI=1S/C8H20N.FH.2H2O/c1-5-9(6-2,7-3)8-4;;;/h5-8H2,1-4H3;1H;2*1H2/q+1;;;/p-1
InChIKey HRTKQUHFGZFPPF-UHFFFAOYSA-M
SMILES [N+](CC)(CC)(CC)CC.[F-].[H]O[H].[H]O[H]
CAS DataBase Reference 665-46-3(CAS DataBase Reference)
EPA Substance Registry System Tetraethylammonium fluoride (665-46-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H335-H332-H315-H302-H312
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36
WGK Germany  3
3-9
HS Code  2921199990
NFPA 704
0
2 0

Tetraethylammonium fluoride dihydrate price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T0838 Tetraethylammonium Fluoride Hydrate >98.0%(T) 665-46-3 5g $129 2025-07-31 Buy
TCI Chemical T0838 Tetraethylammonium Fluoride Hydrate >98.0%(T) 665-46-3 25g $389 2025-07-31 Buy
TRC T303783 TetraethylammoniumFluoride 665-46-3 100mg $60 2021-12-16 Buy
Ark Pharm P000001702 Tetraethylammonium fluoride 97% 665-46-3 100g $75 2021-12-16 Buy
AK Scientific K089 Tetraethylammoniumfluoridedihydrate 665-46-3 10g $93 2021-12-16 Buy
Product number Packaging Price Buy
T0838 5g $129 Buy
T0838 25g $389 Buy
T303783 100mg $60 Buy
P000001702 100g $75 Buy
K089 10g $93 Buy

Tetraethylammonium fluoride dihydrate Chemical Properties,Uses,Production

Uses

Tetraethylammonium Fluoride Dihydrate is an analog of Tetraethylammonium Chloride (T292700). Tetraethylammonium Chloride can be used as a source of tetraethylammonium ions for various pharmaceutical studies and has the ability to block K+ channels in various tissues. Tetraethylammonium Chloride can also block the transmission of nervous impulses across autonomic ganglions.

Synthesis

Tetraethylammonium iodide

68-05-3

Tetraethylammonium fluoride dihydrate

665-46-3

(1) dissolve 10 g of tetraethylammonium iodide with 99% purity in 25 mL of distilled water, add 60 mL of hydrofluoric acid with a mass concentration of 35%, seal and heat at 50 °C with stirring; (2) ensure that the raw materials are fully reacted for at least 3 h, and then raise the temperature to 110 °C to evaporate the excess hydrogen fluoride gas and by-product hydrogen, and absorb the exhaust gas using calcium oxide, taking care to avoid tetraethylammonium fluoride ionic liquid dehydration; (3) diluting the undehydrated tetraethylammonium fluoride ionic liquid with distilled water, ensuring that the volume ratio of the tetraethylammonium fluoride ionic liquid to distilled water was less than 1:50. AgNO3 solution was added to the diluted solution, and if precipitation was observed to be generated, 20 mL of hydrofluoric acid was continued to be added, and steps (1) and (2) were repeated until no precipitate was generated in order to purify the tetraethylammonium fluoride ionic liquid; (4) The unpurified tetraethylammonium fluoride ionic liquid was dried under high vacuum at 120°C for at least 48 hours to remove water and residual hydrogen fluoride. The viscous liquid obtained needs to be diluted with distilled water to ensure that the volume ratio of viscous liquid to distilled water is less than 1:50, sealed and heated at 60°C, and the residual hydrogen fluoride concentration is detected using a hydrogen detector. If the reading is more than 0.1 ppm, then continue to dry in high vacuum at 120 ℃ until the concentration of hydrogen fluoride is less than 0.1 ppm When the concentration of hydrogen fluoride is detected to be less than 0.1 ppm, the resulting liquid is tetraethylammonium fluoride ionic liquid, and the weight of the final product is 5.67 g. The final product weighs 5.67 g. The final liquid is then dried in high vacuum at 120 ℃ until the concentration of hydrogen fluoride is less than 0.1 ppm.

References

[1] Patent: CN103992275, 2016, B. Location in patent: Paragraph 0264; 0265; 0266; 0267; 0268; 0269

Tetraethylammonium fluoride dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 205)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 info@fdachem.com China 20190 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49975 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29800 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569262 +86-15003564040 1087@dideu.com China 3947 58
SIMAGCHEM CORP
+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626 eric@witopchemical.com China 23541 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850 +86-13986145403; info@fortunachem.com China 5971 58

View Lastest Price from Tetraethylammonium fluoride dihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tetraethylammonium fluoride dihydrate pictures 2025-09-16 Tetraethylammonium fluoride dihydrate
665-46-3
US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
MCU pictures 2025-05-26 MCU
665-46-3
US $67.00 / kg 1kg 0.99 5000 tons Hebei Fengjia New Material Co., Ltd
Tetraethyl Ammonium Fluoride pictures 2024-01-16 Tetraethyl Ammonium Fluoride
665-46-3
US $5.00-0.50 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
  • MCU pictures
  • MCU
    665-46-3
  • US $67.00 / kg
  • 0.99
  • Hebei Fengjia New Material Co., Ltd
TETRAETHYLAMMONIUM FLUORIDE Tetraethylammonium fluoride dihydrate N,N,N-TRIETHYL-ETHANAMINIUFLUORIDE Ethanaminium, N,N,N-triethyl-, fluoride Tetraethylazanium fluoride N,N,N-Triethylethanaminium·fluoride Tetraethylaminium·fluoride TetraethylaMMoniuM Fluoride  [E4N]F Ethanaminium,N,N,N-triethyl-, fluoride (1:1) Tetraethylammonium Fluoride Hydrate> N,N,N-Triethylethanaminiumfluoriddihydrat Tetraethylammonium fluoride 2-hydrate Thiamethoxam Impurity 6 (Clothianidin) 665-46-3 C8H20FN4 C8H20FN2H2O C8H24FNO2 C8H20NF C2H54NF C8H20FN C8H26FNO3 Fluoride Sources Deprotection Protection and Derivatization Synthetic Reagents Ammonium Fluorides (Quaternary) Quaternary Ammonium Compounds Ammonium Fluorides (Quaternary) Quaternary Ammonium Compounds quarternary ammonium salts K00001