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8-Epi PGF2alpha-d4

8-Epi PGF2alpha-d4 Structure
8-Epi PGF2alpha-d4 structure
CAS No.
211105-40-7
Chemical Name:
8-Epi PGF2alpha-d4
Synonyms
IPF2ALPHA-IIID4;8-ISOPROSTANE-D4;8-Epi PGF2alpha-d4;8-iso Prostaglandin F2α-d4;PXGPLTODNUVGFL-FLRLWOSLSA-N;8-ISO PROSTAGLANDIN F2ALPHA-D4;9ALPHA, 11ALPHA, 15S-TRIHYDROXY-(8BETA)-PROSTA-5Z, 13E-DIEN-1-OIC-3,3,4,4-D4 ACID;8-Iso Prostaglandin F2α-[D4] In Methyl Acetate, Concentration: 100μg/mL (Standard)
CBNumber:
CB6149006
Molecular Formula:
C20H30D4O5
Molecular Weight:
358.51
MDL Number:
MFCD00797664
MOL File:
211105-40-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:53:53
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8-Epi PGF2alpha-d4 Properties

storage temp. Store at -20°C
solubility 10 mM Na2CO3: >6.5 mg/ml (from PGF2a),DMF: >100 mg/ml (from PGF2a),DMSO: >100 mg/ml (from PGF2a),Ethanol: >100 mg/ml (from PGF2a),PBS pH 7.2: >10 mg/ml (from PGF2a)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319-H336
Precautionary statements  P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

8-Epi PGF2alpha-d4 price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 316350 8-iso Prostaglandin F2α-d4 ≥99%deuteratedforms(d1-d4) 211105-40-7 25μg $219 2026-04-30 Buy
Cayman Chemical 316350 8-iso Prostaglandin F2α-d4 ≥99%deuteratedforms(d1-d4) 211105-40-7 50μg $416 2026-04-30 Buy
Cayman Chemical 316350 8-iso Prostaglandin F2α-d4 ≥99%deuteratedforms(d1-d4) 211105-40-7 100μg $788 2026-04-30 Buy
Cayman Chemical 316350 8-iso Prostaglandin F2α-d4 ≥99% deuterated forms (d1-d4) 211105-40-7 500μg $2144 2021-12-16 Buy
Medical Isotopes, Inc. 404 8-isoProstaglandin-F2-α(3,3,4,4-d4) 211105-40-7 100ug $890 2021-12-16 Buy
Product number Packaging Price Buy
316350 25μg $219 Buy
316350 50μg $416 Buy
316350 100μg $788 Buy
316350 500μg $2144 Buy
404 100ug $890 Buy

8-Epi PGF2alpha-d4 Chemical Properties, Uses, Production

Uses

8-Iso-PGF2a-d4 (8-iso Prostaglandin F2α-d4) is an active compound. 8-Iso-PGF2a-d4 can be used the internal standard[1].

Biological Activity

8-iso PGF2α-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 8-iso PGF2α by GC- or LC-mass spectrometry. 8-iso Prostaglandin F2α (8-iso PGF2α) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.1,2,3 It circulates in human plasma in two distinct forms - esterified in LDL phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine.1,2 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle.4 Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10-6 M) and I-BOP (3 x 10-7 M) with IC50 values of 1.6 x 10-6 M and 1.8 x 10-6 M, respectively.3

References

1.Morrow, J.D., Hill, K.E., Burk, R.F., et al.A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanismProc. Natl. Acad. Sci. U.S.A.87(23)9383-9387(1990) 2.Morrow, J.D., Harris, T.M., and Roberts, L.J., IINoncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoidsAnal. Biochem.184(1)1-10(1990) 3.Morrow, J.D., Minton, T.A., and Roberts, L.J., IIThe F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonistProstaglandins44(2)155-163(1992) 4.Kiriyama, M., Ushikubi, F., Kobayashi, T., et al.Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cellsBr. J. Pharmacol.122(2)217-224(1997)

8-Epi PGF2alpha-d4 Preparation Products And Raw materials

Raw materials

Preparation Products

8-Epi PGF2alpha-d4 Suppliers

Global Suppliers ( 14)
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai Universal Biotech Co.,Ltd 15921930842 15921930842 yh-wang@univ-bio.com China 25030 58
CHINA ISOTOPE CO., LIMITED 02151600108 13062666369 info@isotopechem.com China 4721 58
Chengdu Peter-like Biotechnology Co., Ltd. 028-81700200 13308200041 2851167782@qq.com China 10763 58
TargetMol 400-821-0310 15002144251 xuexiang.shao@tsbiochem.com China 29128 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai Universal Biotech Co.,Ltd 58
CHINA ISOTOPE CO., LIMITED 58
Chengdu Peter-like Biotechnology Co., Ltd. 58
TargetMol 58

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IPF2ALPHA-IIID4 8-iso Prostaglandin F2α-d4 PXGPLTODNUVGFL-FLRLWOSLSA-N 8-ISO PROSTAGLANDIN F2ALPHA-D4 8-ISOPROSTANE-D4 9ALPHA, 11ALPHA, 15S-TRIHYDROXY-(8BETA)-PROSTA-5Z, 13E-DIEN-1-OIC-3,3,4,4-D4 ACID 8-Iso Prostaglandin F2α-[D4] In Methyl Acetate, Concentration: 100μg/mL (Standard) 8-Epi PGF2alpha-d4 211105-40-7