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TQ05310

TQ05310 Structure
TQ05310 structure
CAS No.
2071196-10-4
Chemical Name:
TQ05310
Synonyms
TQ05310;1,3,5-Triazine-2,4-diamine, N2-(1,1-dimethylethoxy)-N4-[2-(trifluoromethyl)-4-pyridinyl]-6-[6-(trifluoromethyl)-2-pyridinyl]-
CBNumber:
CB614907548
Molecular Formula:
C19H17F6N7O
Molecular Weight:
473.38
MDL Number:
MOL File:
2071196-10-4.mol
Last updated:2025-04-18 09:51:18
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TQ05310 Properties

Boiling point 468.779±55.00 °C(Press: 760.00 Torr)(predicted)
Density 1.466±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka 2.573±0.26(predicted)

TQ05310 Chemical Properties, Uses, Production

Uses

TQ05310 is an orally available inhibitor of IDH2 mutants, targeting both IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM) mutants. TQ05310 inhibits the production of 2-hydroxyglutarate (2-HG) and induces differentiation of cells expressing IDH2-R140Q and IDH2-R172K by inhibiting the enzymatic activity of mutant IDH2. TQ05310 can be used for the study of acute myeloid leukemia[1].

IC 50

IDH2-R140Q: 136.9 nM (IC50); IDH2‐R172K: 37.9 nM (IC50)

References

[1] Mingzhao Gao, et al. "Pharmacological characterization of TQ 05310, a potent inhibitor of isocitrate dehydrogenase 2 R140Q and R172K mutants." Cancer science 110.10 (2019): 3306-3314. DOI:10.1111/cas.14152

TQ05310 Preparation Products And Raw materials

Raw materials

Preparation Products

TQ05310 Suppliers

Global Suppliers ( 2)
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2996 55
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
TargetMol Chemicals Inc. 58

2071196-10-4 (TQ05310) Related Search:

1,3,5-Triazine-2,4-diamine, N2-[2-(trifluoromethyl)-4-pyridinyl]-6-[6-(trifluoromethyl)-2-pyridinyl]- Enasidenib TQ05310 Olutasidenib GSK321
DIM-C-pPhCO2Me

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TQ05310 1,3,5-Triazine-2,4-diamine, N2-(1,1-dimethylethoxy)-N4-[2-(trifluoromethyl)-4-pyridinyl]-6-[6-(trifluoromethyl)-2-pyridinyl]- 2071196-10-4