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ChemicalBook >> CAS DataBase List >>4,5,6,7-Tetrahydro-benzo[b]thiophene-3-carboxylic acid

4,5,6,7-Tetrahydro-benzo[b]thiophene-3-carboxylic acid

4,5,6,7-Tetrahydro-benzo[b]thiophene-3-carboxylic acid Structure
4,5,6,7-Tetrahydro-benzo[b]thiophene-3-carboxylic acid structure
CAS No.
19156-54-8
Chemical Name:
4,5,6,7-Tetrahydro-benzo[b]thiophene-3-carboxylic acid
Synonyms
4,5,6,7-Tetrahy;4,5,6,7-Tetrahydrobenzothiophene-3-carboxylic acid;4,5,6,7-Tetrahydro-ben[B]thiophene-3-carboxylic acid;Benzo[b]thiophene-3-carboxylic acid, 4,5,6,7-tetrahydro-;4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid 97%;2-broMo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid;4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid(SALTDATA: FREE);4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID ISO 9001：2015 REACH
CBNumber:
CB61492125
Molecular Formula:
C9H10O2S
Molecular Weight:
182.24
MDL Number:
MFCD00652575
MOL File:
19156-54-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:53:53
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4,5,6,7-Tetrahydro-benzo[b]thiophene-3-carboxylic acid Properties

Melting point 179-184°C
Boiling point 350.5±42.0 °C(Predicted)
Density 1.317±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 4.35±0.20(Predicted)
form solid
Appearance White to off-white Solid
InChI InChI=1S/C9H10O2S/c10-9(11)7-5-12-8-4-2-1-3-6(7)8/h5H,1-4H2,(H,10,11)
InChIKey TUZZQEHPGHKGRJ-UHFFFAOYSA-N
SMILES C12CCCCC=1C(C(O)=O)=CS2
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P302+P352-P305+P351+P338-P321-P405-P501
WGK Germany  3
HazardClass  IRRITANT
HS Code  2934999090
Storage Class 11 - Combustible Solids
NFPA 704
0
0 0

4,5,6,7-Tetrahydro-benzo[b]thiophene-3-carboxylic acid price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 760188 4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid 97% 19156-54-8 1g $153 2023-06-20 Buy
Apolloscientific OR960181 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid 97% 19156-54-8 250mg $21 2026-06-04 Buy
Apolloscientific OR960181 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid 97% 19156-54-8 1g $22 2026-06-04 Buy
Apolloscientific OR960181 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid 97% 19156-54-8 5g $108 2026-06-04 Buy
Apolloscientific OR960181 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid 97% 19156-54-8 25g $527 2026-06-04 Buy
Product number Packaging Price Buy
760188 1g $153 Buy
OR960181 250mg $21 Buy
OR960181 1g $22 Buy
OR960181 5g $108 Buy
OR960181 25g $527 Buy

4,5,6,7-Tetrahydro-benzo[b]thiophene-3-carboxylic acid Chemical Properties,Uses,Production

Synthesis

Ethyl 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

14559-12-7

4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID

19156-54-8

The general procedure for the synthesis of 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid from ethyl 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate was as follows: general method: potassium hydroxide (KOH, 1.7 g, 30 mmol) was added to ethyl 4,5,6,7-tetrahydrobenzo[B]thiophene-3-carboxylate (30 mmol) in aqueous (H2O. 20 mL) emulsion. The mixture was heated under vigorous stirring until a clarified solution was obtained (about 1 h), then stirring was continued for 30 min. The reaction solution was cooled to room temperature and washed with toluene (PhMe); the aqueous layer was separated and acidified with hydrochloric acid (HCl) to pH 4. The precipitate was collected by filtration and recrystallized with a solvent mixture of ethanol (EtOH)-N,N-dimethylformamide (DMF).

References

[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 12, p. 2446 - 2455
[2] Chemistry of Heterocyclic Compounds, 2015, vol. 50, # 12, p. 1748 - 1755
[3] Khim. Geterotsikl. Soedin., 2014, vol. 50, # 12, p. 1900 - 1907,8

4,5,6,7-Tetrahydro-benzo[b]thiophene-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Ethyl 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

Preparation Products

4,5,6,7-Tetrahydro-benzo[b]thiophene-3-carboxylic acid Suppliers

Global( 49)Suppliers
Supplier Tel Email Country ProdList Advantage
Zhengzhou Ruke Biological Co., Ltd. 15981811963 1410472904@qq.com China 5824 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
Shanghai ZaiQi Bio-Tech Co., Ltd. 021-54824098, 021-37212705 021-37212706, 13391256916 sales@chemzq.com China 569 55
Shanghai Leto Pharmatech Co.,Ltd. 86-021-5821 5861; 18016401466 sales@letopharm.com China 235 58
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 021-54824098 chemfun@chemfun.net China 489 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Supplier Advantage
Zhengzhou Ruke Biological Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
Shanghai ZaiQi Bio-Tech Co., Ltd. 55
Shanghai Leto Pharmatech Co.,Ltd. 58
Chemfun Medical Technology(Shanghai) Co., Ltd. 58
Sigma-Aldrich 80

View Lastest Price from 4,5,6,7-Tetrahydro-benzo[b]thiophene-3-carboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID pictures 2026-08-20 4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID
19156-54-8
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID pictures 2019-12-25 4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID
19156-54-8
 $1.00 1g ≥98% Career Henan Chemical Co

4,5,6,7-Tetrahydro-benzo[b]thiophene-3-carboxylic acid Spectrum

4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID(19156-54-8)1HNMR

19156-54-8(4,5,6,7-Tetrahydro-benzo[b]thiophene-3-carboxylic acid)Related Search:

2-Amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid methyl ester Ethyl 2-acetamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-[(2-chloroacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate AURORA 3766 AKOS 93369
BUTTPARK 128\48-16 AKOS AUF1322 AKOS 92930 AKOS 89941 BUTTPARK 123\48-20
Ethyl 2-(((4-chlorophenyl)amino)carbonylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-((thioxo((4-(trifluoromethoxy)phenyl)amino)methyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-((2,2-dicyanovinyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-((3-(2-chlorophenyl)-5-methylisoxazol-4-yl)carbonylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-(2,2,3,3,4,4,4-heptafluorobutanoylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
Ethyl 2-(((1,3-dioxoindan-2-ylidene)methyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-(((4-(trifluoromethoxy)phenyl)amino)carbonylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-[2-(2,4-dichlorophenoxy)acetamido]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

1of4

4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid(SALTDATA: FREE) 4,5,6,7-Tetrahydro-ben[B]thiophene-3-carboxylic acid 2-broMo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid 4,5,6,7-Tetrahydrobenzothiophene-3-carboxylic acid 4,5,6,7-Tetrahy Benzo[b]thiophene-3-carboxylic acid, 4,5,6,7-tetrahydro- 4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid 97% 4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID ISO 9001：2015 REACH 19156-54-8 C9H9O2S