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1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate

1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Structure
1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate structure
CAS No.
161491-24-3
Chemical Name:
1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
Synonyms
Methyl N-Boc-4-piperidone-3-carboxylate;1-Boc-4-oxo-3-piperidine carboxylic acid Methyl ester;methyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate;1-O-tert-butyl 3-O-methyl 4-oxopiperidine-1,3-dicarboxylate;N-BOC-3-carbomethoxy-4-piperidone;1-tert-Butyl 3-methyl 4-oxopiperidine-;Methyl N-BOC-4-piperidine-3-carboxylate;Methyl 1-BOC-4-oxopiperidine-3-carboxylate;METHYL N-BOC-4-OXOPIPERIDINE-3-CARBOXYLATE;Methyl1-N-Boc4-oxopiperidine-3-carboxylate
CBNumber:
CB61501216
Molecular Formula:
C12H19NO5
Molecular Weight:
257.28
MDL Number:
MFCD08752608
MOL File:
161491-24-3.mol
MSDS File:
SDS
Last updated:2026-05-28 03:08:12
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1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Properties

Melting point 32-34 °C
Boiling point 350.0±42.0 °C(Predicted)
Density 1.175±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
pka 11.06±0.20(Predicted)
Appearance White to yellow Solid
InChI InChI=1S/C12H19NO5/c1-12(2,3)18-11(16)13-6-5-9(14)8(7-13)10(15)17-4/h8H,5-7H2,1-4H3
InChIKey HBWUTYLVFYVXML-UHFFFAOYSA-N
SMILES N1(C(OC(C)(C)C)=O)CCC(=O)C(C(OC)=O)C1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
HS Code  2933399990

1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical M3338 1-tert-Butyl 3-Methyl 4-Oxopiperidine-1,3-dicarboxylate 161491-24-3 5G $33 2026-04-30 Buy
TCI Chemical M3338 1-tert-Butyl 3-Methyl 4-Oxopiperidine-1,3-dicarboxylate 161491-24-3 25G $101 2026-04-30 Buy
Usbiological 263847 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Asreported 161491-24-3 500mg $389 2026-06-03 Buy
Usbiological 263847 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Asreported 161491-24-3 1g $556 2026-06-03 Buy
Usbiological 263847 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Asreported 161491-24-3 2g $805 2026-06-03 Buy
Product number Packaging Price Buy
M3338 5G $33 Buy
M3338 25G $101 Buy
263847 500mg $389 Buy
263847 1g $556 Buy
263847 2g $805 Buy

1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Chemical Properties, Uses, Production

Application

1-tert-butyl 4-oxopiperidinium-1,3-dicarboxylic acid ester and 3-methyl ester can be used as organic synthesis intermediates and pharmaceutical intermediates in laboratory research and development processes and chemical and pharmaceutical synthesis processes.

Chemical Properties

White to Light yellow powder to crystal

Synthesis

N-(tert-Butoxycarbonyl)-4-piperidone

79099-07-3

Dimethyl carbonate

616-38-6

1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate

161491-24-3

60% sodium hydride (3.5 g, 88 mmol) was suspended in anhydrous toluene (50 mL) at room temperature and protected by nitrogen. Dimethyl carbonate (4.32 g, 48.0 mmol) was added slowly and dropwise to this suspension over a period of 0.5 hours. After the addition of a few drops of methanol, a solution of N-tert-butoxycarbonyl-4-piperidone (4.8 g, 24 mmol) dissolved in anhydrous toluene (20 mL) was added dropwise to the reaction mixture while maintaining the reaction system at 80 °C with stirring. The reaction mixture was continued to be stirred at the same temperature for 3 h. The reaction mixture was subsequently cooled to 0 °C (ice bath) and the pH was adjusted to 6-6.5 with acetic acid. the resulting cold mixture was diluted with water (10 mL) and the pH was adjusted to 8 with 5% sodium hydroxide solution. the toluene layer was separated and the aqueous layer was extracted with toluene (20 mL). The combined organic layers were dried with anhydrous sodium sulfate and concentrated under reduced pressure. The product was dried under vacuum to afford methyl methyl-1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate (5.0 g, 80% yield). The resulting compound did not require further purification and could be used directly in the subsequent reaction.

References

[1] European Journal of Medicinal Chemistry, 2009, vol. 44, # 10, p. 4063 - 4069
[2] Patent: WO2016/123571, 2016, A1. Location in patent: Paragraph 00265
[3] Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13271 - 13280
[4] Journal of the American Chemical Society, 2015, vol. 137, # 21, p. 6738 - 6741
[5] Patent: CN107163045, 2017, A. Location in patent: Paragraph 0037; 0038

1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate synthesis

24424-99-5
71486-53-8
161491-24-3
Synthesis of 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate from Di-tert-butyl dicarbonate and Methyl 4-oxo-3-piperidinecarboxylate hydrochloride

1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Preparation Products And Raw materials

Raw materials

Methyl 4-oxo-3-piperidinecarboxylate hydrochloride 4-Oxo-piperidine-3-carboxylic acid methyl ester Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride Sodium hydride Dimethyl carbonate
Mineral oil N-(tert-Butoxycarbonyl)-4-piperidone Di-tert-butyl dicarbonate

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Preparation Products

tert-butyl 4-hydroxy-3-(hydroxymethyl)piperidine-1-carboxylate

1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Suppliers

Global Suppliers ( 144)
Supplier Tel Email Country ProdList Advantage
Hangzhou Changjiu Pharmaceutical Technology Co. , Ltd. 18918890396; 18918890396 49087067@qq.com China 53 58
Shanghai Hao Yun Chemical Science Co.,Ltd. 021-68367562 sales@haoyunchem.com China 493 55
Chengdu jingzhihuacheng Chemical Technology Co., Ltd. 028-37664989 15900794981 873239557@qq.com China 1050 58
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 28-83379370 13880556291 tcy@tcypharm.com China 509 57
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Sphchem Co., Ltd. 021-56491756 13512199871 2819742715@qq.com China 3994 55
Supplier Advantage
Hangzhou Changjiu Pharmaceutical Technology Co. , Ltd. 58
Shanghai Hao Yun Chemical Science Co.,Ltd. 55
Chengdu jingzhihuacheng Chemical Technology Co., Ltd. 58
Jia Xing Isenchem Co.,Ltd 66
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 57
Pure Chemistry Scientific Inc. 62
Tetranov Biopharm 64
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Sphchem Co., Ltd. 55

View Latest Price from 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl N-Boc-4-piperidone-3-carboxylate pictures 2026-09-02 Methyl N-Boc-4-piperidone-3-carboxylate
161491-24-3
 $1.00-200.00 1KG 99%, 99.5% Sublimated Henan Fengda Chemical Co., Ltd
1-(tert-butyl) 3-methyl 4-oxopiperidine -1,3-dicarboxylate pictures 2024-07-06 1-(tert-butyl) 3-methyl 4-oxopiperidine -1,3-dicarboxylate
161491-24-3
 $300.00 1kg 98% 2mt/month Sach biotech Co.,Ltd
1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate pictures 2019-08-06 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
161491-24-3
 $1.00 1KG 98% 10KG Career Henan Chemical Co

1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Spectrum

1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate(161491-24-3)1HNMR

161491-24-3 (1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate) Related Search:

1-tert-Butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate Methyl 6-bromo-3-oxo-3,4-dihydropyrazine-2-carboxylate 1-tert-Butoxycarbonyl-4-oxo-3-piperidinecarboxylate benzyl ester 1-Boc-3-formyl-4-oxo-piperidine 1-tert-Butyl 3-ethyl 3-methyl-4-oxopiperidine-1,3-dicarboxylate
4-Oxo-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 1-Boc-3-methyl-piperidin-4-one 3-Methyl-4-oxo-1-piperidinecarboxylic acid ethyl ester N-Boc-3-carboethoxy-4-piperidone dimethyl 4-oxopiperidine-1,3-dicarboxylate
Methyl N-Boc-piperidine-3-carboxylate Methyl 1-methyl-4-oxopiperidine-3-carboxylate 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate

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METHYL N-BOC-4-OXOPIPERIDINE-3-CARBOXYLATE 1-N-Boc Methyl 4-oxopiperidine-3-carboxylate Methyl1-N-Boc4-oxopiperidine-3-carboxylate 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate 1-(tert-Butoxycarbonyl)-3-Methyl-4-oxopiperidine-3-carboxylic acid 1-N-Boc methyl 4-oxopiperidine-3-carboxylate, 1-tert-butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate 1-tert-butoxycarbonyl-4-oxo-3-piperidine carboxylate methyl ester 1,3-Piperidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) 3-Methyl ester Methyl 1-BOC-4-oxopiperidine-3-carboxylate Methyl N-Boc-4-Oxopyrrolidine-3-carboxylate 1-tert-Butyl 3-methyl 4-oxopiperidine- Methyl N-BOC-4-piperidine-3-carboxylate 1-tert-Butyl 3-Methyl 4-oxo-1,3-piperidinedicarboxylate 1-(1,1-Dimethylethyl) 3-methyl 4-oxo-1,3-piperidinedicarboxylate N-BOC-3-carbomethoxy-4-piperidone 4-Oxo-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester，Relacorilant intermediate 1-Boc-4-oxo-3-piperidine carboxylic acid Methyl ester 1-O-tert-butyl 3-O-methyl 4-oxopiperidine-1,3-dicarboxylate methyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate Methyl N-Boc-4-piperidone-3-carboxylate 161491-24-3 pharmacetical