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AZD 5438

AZD 5438 structure

CAS No.: 602306-29-6

Chemical Name:: AZD 5438

Synonyms: AZD;CS-1903;AZD 5438;AZD5438, >=98%;AZD5438 ，S2621;AZD 5438; AZD5438;AZD 5438 USP/EP/BP;AZD5438 >=97% (HPLC);AZD-5438, 10 mM in DMSO;4-[2-Methyl-1-(1-Methylethyl)-1H-iMidazol-5-yl]-N-[4-(Methylsulfonyl)phenyl]-

CBNumber:: CB61512498

Molecular Formula:: C18H21N5O2S

Molecular Weight:: 371.46

MDL Number:: MFCD11112135

MOL File:: 602306-29-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
AZD5438 ≥97% (HPLC)	SML1855	5MG	$121
AZD5438 ≥97% (HPLC)	SML1855	25MG	$467
AZD 5438 ≥98%	21598	5mg	$98
AZD 5438 ≥98%	21598	10mg	$185
AZD 5438 ≥98%	21598	25mg	$412
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AZD 5438 Properties

Boiling point	655.2±65.0 °C(Predicted)
Density	1.31
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥42.1 mg/mL in EtOH
form	solid
pka	4.08±0.50(Predicted)
color	White to light yellow
InChI	InChI=1S/C18H21N5O2S/c1-12(2)23-13(3)20-11-17(23)16-9-10-19-18(22-16)21-14-5-7-15(8-6-14)26(4,24)25/h5-12H,1-4H3,(H,19,21,22)
InChIKey	WJRRGYBTGDJBFX-UHFFFAOYSA-N
SMILES	C1(NC2=CC=C(S(C)(=O)=O)C=C2)=NC=CC(C2N(C(C)C)C(C)=NC=2)=N1
FDA UNII	276Z913G29
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H401
Precautionary statements	P273-P501
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

AZD 5438 price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1855	AZD5438 ≥97% (HPLC)	602306-29-6	5MG	$121	2026-04-30	Buy
Sigma-Aldrich	SML1855	AZD5438 ≥97% (HPLC)	602306-29-6	25MG	$467	2026-04-30	Buy
Cayman Chemical	21598	AZD 5438 ≥98%	602306-29-6	5mg	$98	2026-04-30	Buy
Cayman Chemical	21598	AZD 5438 ≥98%	602306-29-6	10mg	$185	2026-04-30	Buy
Cayman Chemical	21598	AZD 5438 ≥98%	602306-29-6	25mg	$412	2026-04-30	Buy

Product number	Packaging	Price	Buy
SML1855	5MG	$121	Buy
SML1855	25MG	$467	Buy
21598	5mg	$98	Buy
21598	10mg	$185	Buy
21598	25mg	$412	Buy

AZD 5438 Chemical Properties,Uses,Production

Uses

AZD 5438 is a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, which leads to leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.

Definition

ChEBI: 4-(2-methyl-3-propan-2-yl-4-imidazolyl)-N-(4-methylsulfonylphenyl)-2-pyrimidinamine is a sulfonamide.

Biological Activity

azd5438 is a potent small molecule inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9 with half maximal inhibitory concentration ic50 of 16 nmol/l, 6 nmol/l and 20 nmol/l respectively. azd5438 has also been found to potently inhibit the human cyclin e/cdk2 complex, the cyclin b1/cdk1 complex and the cyclin a/cdk2 complex with ic50 of 0.006 μm, 0.016 μm and 0.045 μm respectively. in previous studies, azd5438 has exhibited significant anti-proliferative activity in a few human tumor cell lines with ic50 ranging from 0.2 μmol/l to 1.7 μmol/l, in which the phosphorylation of a few proteins, including cdk substrates prb, nucleolin, protein phosphatase 1a and rna polymerase ii cooh-terminal domain, and cell cycling at g2-m, s and g1 phases were inhibited.

in vivo

AZD5438 (50 mg/kg twice daily or 75 mg/kg, p.o.) inhibits human tumor xenograft growth. In vivo, AZD5438 reduces the proportion of actively cycling cells. Further pharmacodynamic analysis of AZD5438-treated SW620 xenografts shows that efficacious doses of AZD5438 (>40% tumor growth inhibition) maintains suppression of biomarkers, such as phospho-pRbSer249/Thr252, for up to 16 hours following a single oral dose^[1].

IC 50

cdk2-cyclin E: 6 nM (IC₅₀); cdk2-cyclin A: 45 nM (IC₅₀); cdk5-p25: 14 nM (IC₅₀); cdk1-cyclin B1: 16 nM (IC₅₀); cdk9-cyclin T: 20 nM (IC₅₀); cdk6-cyclin D3: 21 nM (IC₅₀); cdk4-cyclin D1: 449 nM (IC₅₀); cdk7-cyclin H: 821 nM (IC₅₀)

storage

Desiccate at RT

References

[1]camidge dr1, smethurst d, growcott j, barrass nc, foster jr, febbraro s, swaisland h, hughes a. a first-in-man phase i tolerability and pharmacokinetic study of the cyclin-dependent kinase-inhibitor azd5438 in healthy male volunteers. cancer chemother pharmacol. 2007 aug;60(3):391-8. epub 2006 nov 18.
[2]byth kf, thomas a, hughes g, forder c, mcgregor a, geh c, oakes s, green c, walker m, newcombe n, green s, growcott j, barker a, wilkinson rw. azd5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. mol cancer ther. 2009 jul;8(7):1856-66. doi: 10.1158/1535-7163.mct-08-0836. epub 2009 jun 9.

AZD 5438 Preparation Products And Raw materials

Raw materials

Preparation Products

AZD 5438 Suppliers

Global( 181)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Dideu Industries Group Limited	+8617392712697	1022@dideu.com	China	29091	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10378	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49860	58
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +86-15988602810	sales@anbuchem.com	China	5812	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +86-15965530500	nickzhang@hangyubiotech.com	China	9930	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
BOC Sciences	58
Zhejiang J&C Biological Technology Co.,Limited	58
GIHI CHEMICALS CO.,LIMITED	58
Zhengzhou Anbu Chem Co.,Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58

View Lastest Price from AZD 5438 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-27	AZD-5438 602306-29-6	$44.00-113.00		99.87%	10g	TargetMol Chemicals Inc.
2025-08-21	AZD-5438；AZD5438 602306-29-6		10g	99.0%min. HPLC	1000kg	HangZhou RunYan Pharma Technology Co.,LTD.
2019-12-26	AZD 5438 602306-29-6	$9.80	1g	≥99%	100kg	Career Henan Chemical Co

AZD-5438
602306-29-6
$44.00-113.00
99.87%
TargetMol Chemicals Inc.

AZD-5438；AZD5438
602306-29-6
99.0%min. HPLC
HangZhou RunYan Pharma Technology Co.,LTD.

AZD 5438
602306-29-6
$9.80
≥99%
Career Henan Chemical Co

AZD 5438 Spectrum

AZD 5438(602306-29-6)¹HNMR

602306-29-6(AZD 5438)Related Search:

p-Menthane 4-METHYL-2-PENTYNE Cumene Alisertib (MLN8237) BMS-265246

PD 0332991 HCl (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Flavopiridol (Alvocidib) HCl Olaparib 1-ISOPROPYL-2,5-DIMETHYLIMIDAZOLE

AZD 5438

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2-Pyrimidinamine,4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]- AZD 5438 4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine 4-[2-Methyl-1-(1-Methylethyl)-1H-iMidazol-5-yl]-N-[4-(Methylsulfonyl)phenyl]- 2-Pyrimidinamine,4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-(AZD 5438) 4-[2-Methyl-1-isopropyl-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine 4-[2-Methyl-1-isopropyl-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine AZD 5438 AZD 5438 4-[2-Methyl-1-isopropyl-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine AZD5438, >=98% CS-1903 AZD 5438; AZD5438 AZD5438 >=97% (HPLC) AZD 5438 USP/EP/BP AZD-5438, 10 mM in DMSO AZD5438 ，S2621 AZD 602306-29-6 C18H21N5O2S Inhibitors API intermediates Potent inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9.