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2'-Deoxy-5'-O-DMT-2'-fluorouridine

2'-Deoxy-5'-O-DMT-2'-fluorouridine structure

CAS No.: 146954-74-7

Chemical Name:: 2'-Deoxy-5'-O-DMT-2'-fluorouridine

Synonyms: 2'-F-dU;1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione;DMT-2'-F-dU;DMT-2'-F-U;5-DMT-2'-F-dT;5'-DMT-2'-F-dU;1-((2R,3R,4R,5R);5'-O-DMT-2'-F-dU;5'-O-DMTr-2'-F-dU;2'-F-5'-O-DMT-2'-dU

CBNumber:: CB6156598

Molecular Formula:: C30H29FN2O7

Molecular Weight:: 548.56

MDL Number:: MFCD06657648

MOL File:: 146954-74-7.mol

MSDS File:: SDS

Last updated:2026-04-21 11:20:27

Product description	Number	Pack Size	Price
2'-Deoxy-2'-fluorouridine-5'-triphosphate tetra lithium salt Asreported	295910	1mg	$425
2'-Deoxy-5'-O-DMT-2'-fluorouridine Asreported	295758	1g	$322
2'-Deoxy-2'-fluorouridine-5'-triphosphate tetra lithium salt Asreported	295910	2mg	$618
2'-Deoxy-5'-O-DMT-2'-fluorouridine Asreported	295758	2g	$460
2'-Deoxy-2'-fluorouridine-5'-triphosphate tetra lithium salt Asreported	295910	5mg	$901

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2'-Deoxy-5'-O-DMT-2'-fluorouridine Properties

Density	1.38±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	9.39±0.10(Predicted)
form	Powder
color	White to Pale Yellow
InChIKey	CSSFZSSZXOCCJB-MNBKXICWNA-N
SMILES	N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2=CC=C(C=C2)OC)C2=CC=C(C=C2)OC)[C@@H](O)[C@H]1F \|&1:8,10,36,38,r\|

SAFETY

Risk and Safety Statements

HS Code	2934999090

2'-Deoxy-5'-O-DMT-2'-fluorouridine price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	295910	2'-Deoxy-2'-fluorouridine-5'-triphosphate tetra lithium salt Asreported	146954-74-7	1mg	$425	2026-06-03	Buy
Usbiological	295758	2'-Deoxy-5'-O-DMT-2'-fluorouridine Asreported	146954-74-7	1g	$322	2026-06-03	Buy
Usbiological	295910	2'-Deoxy-2'-fluorouridine-5'-triphosphate tetra lithium salt Asreported	146954-74-7	2mg	$618	2026-06-03	Buy
Usbiological	295758	2'-Deoxy-5'-O-DMT-2'-fluorouridine Asreported	146954-74-7	2g	$460	2026-06-03	Buy
Usbiological	295910	2'-Deoxy-2'-fluorouridine-5'-triphosphate tetra lithium salt Asreported	146954-74-7	5mg	$901	2026-06-03	Buy

Product number	Packaging	Price	Buy
295910	1mg	$425	Buy
295758	1g	$322	Buy
295910	2mg	$618	Buy
295758	2g	$460	Buy
295910	5mg	$901	Buy

2'-Deoxy-5'-O-DMT-2'-fluorouridine Chemical Properties,Uses,Production

Uses

2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity[1].

Definition

2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity.

Biological Activity

2'-Deoxy-5'-O-DMT-2'-fluorouridine (compound 15h) has 100% inhibition against YFV at 20 mM. 2'-Deoxy-5'-O-DMT-2'-fluorouridine proves to be noncytotoxic at concentrations up to 20 mM.

Synthesis

40615-36-9

2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-xylofuranosyl)-

56287-17-3

146954-74-7

2'-Deoxy-2'-fluorouridine (3.00 g, 12.2 mmol) was dissolved in anhydrous pyridine, and the decompression concentration operation was repeated three times to achieve dehydration azeotropic distillation. Subsequently, the reaction mixture was dissolved in anhydrous pyridine (120 mL) under argon protection, 4,4'-dimethoxytrityl chloride (4.55 g, 13.4 mmol) was added, and the reaction was stirred for 3 hours at room temperature. After completion of the reaction, ethyl acetate (150 mL) and water (60 mL) were added to the reaction mixture and layered. The organic layer was washed sequentially with 5% aqueous sodium bicarbonate (20 mL x 3), water (20 mL) and saturated saline (20 mL), followed by drying with anhydrous sodium sulfate. After filtration, the solvent was removed by evaporation and the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 50:50 to 0:100 (v/v) containing 1% triethylamine). The fraction containing the target product was collected and concentrated to give 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (8.48 g, quantitative yield).

References

[1] Christopher McGuigan, et al. Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues. ChemistryOpen. 2016 Jan 21;5(3):227-35. DOI:10.1002/open.201500216

2'-Deoxy-5'-O-DMT-2'-fluorouridine Preparation Products And Raw materials

Raw materials

4,4'-Dimethoxytrityl chloride 4,4'-dimethoxytrityl alcohol 2'-Deoxy-2'-fluoro-L-uridine 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-xylofuranosyl)-

Preparation Products

2'-Deoxy-5'-O-DMT-2'-fluorouridine Suppliers

Global( 146)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Allbiosyn Biotechnology Co.,Ltd.	+8618666985712	info@allbiosyn.com	China	295	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5742	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8741	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20582	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9539	58

Supplier	Advantage
Allbiosyn Biotechnology Co.,Ltd.	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Antai Fine Chemical Technology Co.,Limited	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Shanghai UCHEM Inc.	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58

View Lastest Price from 2'-Deoxy-5'-O-DMT-2'-fluorouridine manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-21	2'-Deoxy-5'-O-DMT-2'-fluorouridine 146954-74-7			10g	TargetMol Chemicals Inc.
2026-03-30	2'-Deoxy-5'-O-DMT-2'-fluorouridine 146954-74-7	1G	98%	2000	Shenzhen Nexcon Pharmatechs Ltd.
2025-04-04	5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE 146954-74-7	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2'-Deoxy-5'-O-DMT-2'-fluorouridine
146954-74-7
$0.00
TargetMol Chemicals Inc.

2'-Deoxy-5'-O-DMT-2'-fluorouridine
146954-74-7
98%
Shenzhen Nexcon Pharmatechs Ltd.

5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE
146954-74-7
98%
Henan Aochuang Chemical Co.,Ltd.

146954-74-7(2'-Deoxy-5'-O-DMT-2'-fluorouridine)Related Search:

N-Acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]cytidine 5'-O-DMT-2'-TBDMS-Uridine 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-O-METHYLURIDINE 2'-O-TBDMS-5'-O-DMT-N4-Ac cytidin 5'-O-(4,4'-Dimethoxytrityl)uridine

5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE 2'-Fluoro-2'-deoxyuridine 2'-Fluoro-5'-O-dimethoxytrityluridine-3'-O-cyanoethyldiisopropropylphosphoramidite

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5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE 2'-Deoxy-5'-O-DMT-2'-fluoro-D-uridine 2'-Deoxy-5'-O-DMT-2'-fluorouridine 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine 5'-O-(4,4'-DiMethoxytrityl)-2'-fluoro-2'-deoxyuridine 1-((2R,3R,4R,5R) -3-fluoro-4-hydroxytetrahydrofuran-2-yl) -5-((Bis(4-methoxyphenyl) 2'-Deoxy-5'-O-DMTr-2'-fluoro-uridine 1-(5-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-3-FLUORO-4-HYDROXYOXOLAN-2-YL)-3H-PYRIMIDINE-2,4- 5'-DMT-2'-F-dU Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro- 5'-O-DMT-2'-F-dU 2’-Deoxy-5’-O-(4,4’-dimethoxytrityl)-2’-fluorouridine 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE USP/EP/BP 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine, 98%, DMT-2'-F-U 5-DMT-2'-F-dT 5'-ODMT-2'-Fluoro Uridine 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-3-fluoro-4-hydroxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione 5'-O-DMT-2'-fluoro-2'-deoxyuridine 5'-O-DMT-2'-F-deoxyuridine 5’-O-(4,4’-Dimethoxytrityl)-2’-fluoro-2’-deoxyuridine 2'-F-5'-O-DMT-2'-dU 5'-O-DMTr-2'-F-dU 5 ' - 0 - (4,4'- DIMETHOXYTRI - TYL) - 2'- FLUORO- D- URDINE 5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-Fluoro-2'-Deoxyuridine 5'-O-DMT-2'-Fluoro-2'-deoxyuridine 5'-O-DMT-2'-F-dU, 5'-O-(4,4’-dimethoxytrityl)-2’-fluoro-2’-deoxyuridine 1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione 2'-F-dU DMT-2'-F-dU 146954-74-7 C30H29N2O7F Modified（deoxy）nucleoside