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N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine

N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine structure

CAS No.: 80376-66-5

Chemical Name:: N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine

Synonyms: meyers' tms form;N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine;N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine,98%;N'-tert-butyl-N-methyl-N-(trimethylsilylmethyl)methanimidamide;Methanimidamide, N'-(1,1-dimethylethyl)-N-methyl-N-[(trimethylsilyl)methyl]-;N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidineMeyers' TMS form reagent

CBNumber:: CB6160140

Molecular Formula:: C10H24N2Si

Molecular Weight:: 200.4

MDL Number:: MFCD00272687

MOL File:: 80376-66-5.mol

Last updated:2026-09-12 18:53:57

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N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine Properties

Boiling point	78-80 °C (7 mmHg)
refractive index	1.45-1.452
storage temp.	0-6°C

SAFETY

Risk and Safety Statements

Hazard Codes	Xn
Risk Statements	20/21/22
Safety Statements	36/37

N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine Chemical Properties, Uses, Production

Chemical Properties

CLEAR PALE YELLOW LIQUID

Uses

N-METHYL-N-TRIMETHYLSILYLMETHYL-N'-TERT-BUTYLFORMAMIDINE conveniently effects the transformation of ketones and aldehydes to homologated nitriles, amines, aldehydes, and ketones.

Synthesis

N-METHYL-N-TRIMETHYLSILYLMETHYL-N'-TERT-BUTYLFORMAMIDINE is easily synthesized by a two-step procedure (eq 1).1 Initially, the condensation of t-Butylamine with either N,N-Dimethylformamide or dimethylformamide dimethyl acetal cleanly affords N′-t-Butyl-N,N-dimethylformamidine. Subsequent lithiation and silylation with Chlorotrimethylsilane results in a 70% overall yield of the purified title reagent.
N-METHYL-N-TRIMETHYLSILYLMETHYL-N'-TERT-BUTYLFORMAMIDINE synthesis route

storage

The reagent should be handled in a fume hood. Refrigeration should be used for prolonged storage.

N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine Suppliers

Global Suppliers ( 4)

Supplier	Tel	Email	Country	ProdList	Advantage
Acros Organics	--	info@acros.com	Belgium	6756	81
3B Scientific Corporation	--	sales@3bsc.com	United States	6637	47
Service Chemical Inc.	--	sales@chemos-group.com	Germany	6281	71
Kanto Chemical Co., Inc.	--	reag-info@gms.kanto.co.jp	Japan	6739	74

Supplier	Advantage
Acros Organics	81
3B Scientific Corporation	47
Service Chemical Inc.	71
Kanto Chemical Co., Inc.	74

80376-66-5 (N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine) Related Search:

N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine N'-tert-Butyl-N,N-dimethylformamidine (Trimethylsilyl)methylamine

meyers' tms form N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine,98% N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidineMeyers' TMS form reagent Methanimidamide, N'-(1,1-dimethylethyl)-N-methyl-N-[(trimethylsilyl)methyl]- N'-tert-butyl-N-methyl-N-(trimethylsilylmethyl)methanimidamide N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine 80376-66-5 C10H24N2Si