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Acros Organics |
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+32 14/57.52.11 |
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info@acros.com |
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| | N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine Basic information |
| Product Name: | N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine | | Synonyms: | meyers' tms form;N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine,98%;N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidineMeyers' TMS form reagent;Methanimidamide, N'-(1,1-dimethylethyl)-N-methyl-N-[(trimethylsilyl)methyl]-;N'-tert-butyl-N-methyl-N-(trimethylsilylmethyl)methanimidamide;N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine | | CAS: | 80376-66-5 | | MF: | C10H24N2Si | | MW: | 200.4 | | EINECS: | | | Product Categories: | | | Mol File: | 80376-66-5.mol |  |
| | N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine Chemical Properties |
| Boiling point | 78-80 °C (7 mmHg) | | refractive index | 1.45-1.452 | | storage temp. | 0-6°C |
| Provider | Language |
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ACROS
| English |
| | N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine Usage And Synthesis |
| Chemical Properties | CLEAR PALE YELLOW LIQUID | | Uses | N-METHYL-N-TRIMETHYLSILYLMETHYL-N'-TERT-BUTYLFORMAMIDINE conveniently effects the transformation of ketones and aldehydes to homologated nitriles, amines, aldehydes, and ketones.
| | Synthesis |
N-METHYL-N-TRIMETHYLSILYLMETHYL-N'-TERT-BUTYLFORMAMIDINE is easily synthesized by a two-step procedure (eq 1).1 Initially, the condensation of t-Butylamine with either N,N-Dimethylformamide or dimethylformamide dimethyl acetal cleanly affords N′-t-Butyl-N,N-dimethylformamidine. Subsequent lithiation and silylation with Chlorotrimethylsilane results in a 70% overall yield of the purified title reagent.
| | storage | The reagent should be handled in a fume hood. Refrigeration should be used for prolonged storage.
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| | N-Methyl-N-trimethylsilylmethyl-N'-tert-butylformamidine Preparation Products And Raw materials |
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