5-Chloro-2-methylphenylboronic acid
- CAS No.
- 148839-33-2
- Chemical Name:
- 5-Chloro-2-methylphenylboronic acid
- Synonyms
- 5-CHLORO-2-METHYLPHE;5-Chloro-o-tolylboronic Acid;5-Chloro-2-methylphenylboronicaci;2-METHYL-5-CHLOROPHENYLBORONICACID;5-Chloro-2-methylphenylboronic acid;5-Chloro-2-Methylphenyl boconic acid;5-CHLORO-2-METHYLBENZENEBORONIC ACID;5-Chloro-2-methylphenyl boronic acid ,97%;Boronic acid, B-(5-chloro-2-methylphenyl)-;5-Chloro-2-methylphenylboronic acid - [C2230]
- CBNumber:
- CB6161657
- Molecular Formula:
- C7H8BClO2
- Molecular Weight:
- 170.4
- MDL Number:
- MFCD03411939
- MOL File:
- 148839-33-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 162-166 |
|---|---|
| Boiling point | 328.0±52.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 7.63±0.58(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 148839-33-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22-36-22 | |||||||||
| Safety Statements | 26-36/37/39-36-60-37 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
5-Chloro-2-methylphenylboronic acid price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2665 | 5-Chloro-2-methylphenylboronic Acid (contains varying amounts of Anhydride) | 148839-33-2 | 1g | $43 | 2026-04-30 | Buy |
| TCI Chemical | C2665 | 5-Chloro-2-methylphenylboronic Acid (contains varying amounts of Anhydride) | 148839-33-2 | 5g | $153 | 2026-04-30 | Buy |
| Activate Scientific | AS51161 | 5-Chloro-2-methylphenylboronic acid 97% | 148839-33-2 | 1g | $24 | 2026-06-04 | Buy |
| Activate Scientific | AS51161 | 5-Chloro-2-methylphenylboronic acid 97% | 148839-33-2 | 5g | $37 | 2026-06-04 | Buy |
| Apolloscientific | OR10415 | 5-Chloro-2-methylbenzeneboronic acid 97% | 148839-33-2 | 1g | $21 | 2026-06-04 | Buy |
5-Chloro-2-methylphenylboronic acid Chemical Properties, Uses, Production
Chemical Properties
Off-white Cryst
Uses
suzuki reaction
Synthesis
121-43-7
33184-48-4
148839-33-2
The general procedure for the synthesis of 5-chloro-2-methylphenylboronic acid from trimethyl borate and 4-chloro-2-iodotoluene was carried out as follows: firstly, magnesium shavings (0.346 g, 14.25 mmol) were activated by heating in an oven at 120°C for 16 hours. Anhydrous tetrahydrofuran (50 ml) and a small amount of iodine crystals were added to the activated magnesium crumbs using pre-oven dried glassware. Subsequently, 4-chloro-2-iodotoluene was added via syringe and the reaction system was ensured to be in an oxygen-free environment. The reaction mixture was heated and refluxed for 5.5 hours under a continuous flow of argon gas. Upon completion of the reaction, the system was cooled to -78°C (using a dry ice-acetone bath) and a solution of anhydrous tetrahydrofuran (10 ml) of trimethyl borate (2.47 g, 23.76 mmol) was slowly added dropwise. After the dropwise addition, the reaction system was allowed to warm up slowly to room temperature and stirring was continued for 16 hours. At the end of the reaction, the reaction was quenched by careful addition of 1 M hydrochloric acid (20 ml), followed by extraction of the reaction mixture with ether (3 x 50 ml). The organic phases were combined, washed with water (3 x 50 ml), dried with magnesium sulfate and concentrated under reduced pressure. Finally, the residue was washed with hexane to afford the target product 5-chloro-2-methylphenylboronic acid (0.537 g, 26% yield) as a white powder.
References
[1] Patent: US2004/204386, 2004, A1
5-Chloro-2-methylphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
View Latest Price from 5-Chloro-2-methylphenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 5-CHLORO-2-METHYLPHENYLBORONIC ACID
148839-33-2
|
$1.00 | 1KG | 97%-99% | 1kg;5kg;100kg | Career Henan Chemical Co |
-
- 5-CHLORO-2-METHYLPHENYLBORONIC ACID
148839-33-2
- $1.00
- 97%-99%
- Career Henan Chemical Co
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