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(S)-1-Boc-3-hydroxypiperidine

(S)-1-Boc-3-hydroxypiperidine Structure
(S)-1-Boc-3-hydroxypiperidine structure
CAS No.
143900-44-1
Chemical Name:
(S)-1-Boc-3-hydroxypiperidine
Synonyms
tert-butyl (S)-3-hydroxypiperidine-1-carboxylate;(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Ibrutinib Interm 0441;(S)-1-TERT-BUTOXYCARBONYL-3-HYDROXYPIPERIDINE;CAS:143900-44-1;1,1-DiMethylethy;(S)-BOC-piperidinol;Ilutinib impurity 7;(S)-1-BOC-3-PIPERIDINOL;（S）-N-BOC-3-piperidinol
CBNumber:
CB6197360
Molecular Formula:
C10H19NO3
Molecular Weight:
201.26
MDL Number:
MFCD06659041
MOL File:
143900-44-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-23 14:48:42
Request For Quotation

(S)-1-Boc-3-hydroxypiperidine Properties

Melting point 34-40 °C
Boiling point 292.3±33.0 °C(Predicted)
Density 1.107±0.06 g/cm3(Predicted)
Flash point 110 °C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in methanol.
pka 14.74±0.20(Predicted)
form Powder or Crystalline Powder
color White to tan
optical activity [α]22/D +10.0°, c = 1 in chloroform
InChI InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1
InChIKey UIJXHKXIOCDSEB-QMMMGPOBSA-N
SMILES N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1
CAS DataBase Reference 143900-44-1(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39
WGK Germany  3
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
1
2 0

(S)-1-Boc-3-hydroxypiperidine price More Price(81)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 687367 (S)-1-Boc-3-hydroxypiperidine 97% 143900-44-1 1g $123 2026-04-30 Buy
TCI Chemical B4446 (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) 143900-44-1 1g $18 2026-04-30 Buy
TCI Chemical B4446 (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) 143900-44-1 5g $51 2026-04-30 Buy
Usbiological 262045 S-1-Boc-3-hydroxypiperidine Asreported 143900-44-1 5g $322 2026-06-03 Buy
Usbiological 262045 S-1-Boc-3-hydroxypiperidine Asreported 143900-44-1 10g $438 2026-06-03 Buy
Product number Packaging Price Buy
687367 1g $123 Buy
B4446 1g $18 Buy
B4446 5g $51 Buy
262045 5g $322 Buy
262045 10g $438 Buy

(S)-1-Boc-3-hydroxypiperidine Chemical Properties, Uses, Production

Uses

(S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.

Description

(S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield.

Chemical Properties

White powder

Uses

A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.

Uses

(S)-1-Boc-3-hydroxypiperidine is used as pharmaceutical intermediate.

(S)-1-Boc-3-hydroxypiperidine synthesis

98977-36-7
143900-44-1
Synthesis of (S)-1-Boc-3-hydroxypiperidine from 1-Boc-3-piperidone

(S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-3-Hydroxypiperidine hydrochloride (3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine (S)-3-Methoxypiperidine (S)-3-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester (S)-1-(tert-Butoxycarbonyl)piperidin-3-yl methanesulfonate

(S)-1-Boc-3-hydroxypiperidine Suppliers

Global Suppliers ( 625)
Supplier Tel Email Country ProdList Advantage
Suzhou lipin Chemical Co., Ltd 0512-67509664 19888480046 3516936381@qq.com China 111 58
Shanghai SE Pharm Co., Ltd 18112588827 sales4@sepharm.com.cn China 285 60
Chiral Quest (Suzhou) Co., Ltd. 0512-62956066 18112603058 kendoll@cqpharm.com China 96 58
Anhui nuoquan pharmaceutical co. LTD 15705561919 chunli.yi@nuozhanchem.com China 90 55
Shanghai Tube Pharmaceutical Co., Ltd. 021-54338626 18017892860 sales@tubepharm.com China 2709 58
Nanjing Tianyuexing Bio-tech Co.,Ltd. 吴经理15305186370 15305186370 david@chicopharm.com China 716 58
Beijing Dongxing Science and Technology Co.,Ltd 15801121354; 15801121354 dx_chem@sina.com China 23 58
Xi'an Sunriver Biotech Ltd. 13991954170 info@sunriverbio.com China 176 58
Anqing CHICO Pharmaceutical Co., Ltd. 18061456370 david@chicopharm.com China 461 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
Suzhou lipin Chemical Co., Ltd 58
Shanghai SE Pharm Co., Ltd 60
Chiral Quest (Suzhou) Co., Ltd. 58
Anhui nuoquan pharmaceutical co. LTD 55
Shanghai Tube Pharmaceutical Co., Ltd. 58
Nanjing Tianyuexing Bio-tech Co.,Ltd. 58
Beijing Dongxing Science and Technology Co.,Ltd 58
Xi'an Sunriver Biotech Ltd. 58
Anqing CHICO Pharmaceutical Co., Ltd. 58
J & K SCIENTIFIC LTD. 76

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View Latest Price from (S)-1-Boc-3-hydroxypiperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-1-Boc-3-hydroxypiperidine pictures 2026-09-17 (S)-1-Boc-3-hydroxypiperidine
143900-44-1
 $63.00-308.00 100g 0.99 100kg Shanghai UCHEM Inc.
(S)-1-Boc-3-hydroxypiperidine pictures 2026-08-20 (S)-1-Boc-3-hydroxypiperidine
143900-44-1
 $1.10 1g 99.0% Min 100 Tons Dideu Industries Group Limited
(S)-1-Boc-3-hydroxypiperidine pictures 2026-08-08 (S)-1-Boc-3-hydroxypiperidine
143900-44-1
 1kg 99.9% 20 tons Hangzhou ICH Biofarm Co., Ltd

(S)-1-Boc-3-hydroxypiperidine Spectrum

(S)-1-Boc-3-hydroxypiperidine(143900-44-1)1HNMR

143900-44-1 ((S)-1-Boc-3-hydroxypiperidine) Related Search:

(R)-1-BOC-3-HYDROXYPIPERIDINE,(R)-1-N-BOC-3-HYDROXYPIPERIDINE,(R)-N-BOC-3-HYDROXYPIPERIDINE tert-Butyl peroxyacetate Haloperidol 3-Hydroxypiperidine tert-Butyl acetate
Btk inhibitor 1 (R enantioMer hydrochloride) Ibrutinib Impurity 21 tert-Butanol N-Boc-2-hydroxypiperidine Ibrutinib
Ibrutinib Impurity 24 (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one (S)-Ibrutinib (S)-3-Hydroxypiperidine Ibrutinib Dimer Impurity
Ibrutinib Impurity 28 Ibrutinib Impurity 25 Acrylic anhydride

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(S)-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE (S)-1-BOC-3-HYDROXYPIPERIDINE (S)-1-BOC-3-PIPERIDINOL (S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPIPERIDINE HYDROCHLORIDE (S)-N-BOC-3-HYDROXY PIPERIDINE (S)-TERT BUTYL-3-HYDROXYPIPERIDINE-1-CARBOXYLATE 1-PIPERIDINECARBOXYLIC ACID, 3-HYDROXY-, 1,1-DIMETHYLETHYL ESTER, (3S)- (S)-1-Boc-3-hydroxypiperidine 97% 15. (S)-tert-butyl 3-hydroxypiperidine-1-carboxylate1 tert-butyl (S)-3-hydroxypiperidine-1-carboxylate143900-44-1 (S)-1-BOC-3-HYDROXYPIPERIDINE 3PC-20160102 [REJECTED MATERIAL IS SENDING BACK TOYOU DUE TO FAILED IN QUALITY PARAMETERS (S)-N-Boc-3-hydroxypiperidine,98%e.e. (S)-1-Boc-3-Hdroxypiperidine (S)-1-Boc-3-hydroxypiperi... tert-Butyl (3S)-3-hydroxypiperidine-1-carboxylate, (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine (S)-tert-butyl 3-hydroxypiperidin-1-carboxylate (3S)-3-Hydroxy-1-piperidinecarboxylic Acid 1,1-diMethylethyl Ester 1,1-DiMethylethy tert- butyl (3S)-3-hydroxy piperidine-1-carboxylate (3S)-hydroxy-1-piperidinecarboxylic acid 1,1-diMethylethyl ester (S)-1-Boc-3-hydroxypiperidine,97% (S)-1-Boc-3-hydroxypiperidine (S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine (S)-1-N-BOC-3-HYDROXY-PIPERIDINE (S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine (S)-3-Hydroxypiperidine, N-BOC protected (S)-1-BOC-Piperidin-3-ol (S)-1-Boc-3-hydroxypiperidine,(S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate (3S)-3-Hydroxypiperidine, N-BOC protected (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine > (S)-1-tert-butyrolactone-3-hydroxypiperidine （S）-N-BOC-3-piperidinol (S)-1-Boc-4-hydroxypiperidine (S) -1-tert-butyloxycarbonyl-3-hydroxypiperidine (S)-1-BOC-3-HYDROXYPIPERIDINE, IBRUTINIB INT (S)-1-Boc-3-hydroxypiperidine ISO 9001：2015 REACH Ibrutinib Interm 0441 (S)-BOC-piperidinol Thieno[2,3-c]pyridine-3-carboxylicacid,2-amino-4,5,6,7-tetrahydro-8-(phenylmethyl)-,ethylester Carbamicacid,N-[2-(2-hydroxyethoxy)ethyl]-,1,6-dimethylethylester 1-Piperidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (3S)- (9CI, ACI) 3-hydroxy-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester (3S)- (9CI ACI) 3-Hydroxy-1-piperidinecarboxylic acid tert-butyl ester (3S)- (S) 1-tert-butoxycarbonyl-3-hydroxypyridine Ilutinib impurity 7 CAS:143900-44-1 (S)-1-Boc-3-hydroxypiperidine (S)-1-(tert-Butoxycarbonyl)-3-carboxypiperidine tert-butyl (S)-3-hydroxypiperidine-1-carboxylate (Intermediate of Ibrutinib) (S)-1-TERT-BUTOXYCARBONYL-3-HYDROXYPIPERIDINE (S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-butyl (S)-3-hydroxypiperidine-1-carboxylate 143900-44-1 14390-44-1 14390-44-1 43900-44-1 C10H19NO3HCl New Products for Chemical Synthesis May/June 2007 Piperazine