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(S)-1-Boc-3-hydroxypiperidine

(S)-1-Boc-3-hydroxypiperidine structure

CAS No.: 143900-44-1

Chemical Name:: (S)-1-Boc-3-hydroxypiperidine

Synonyms: tert-butyl (S)-3-hydroxypiperidine-1-carboxylate;(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Ibrutinib Interm 0441;(S)-1-TERT-BUTOXYCARBONYL-3-HYDROXYPIPERIDINE;CAS:143900-44-1;1,1-DiMethylethy;(S)-BOC-piperidinol;Ilutinib impurity 7;(S)-1-BOC-3-PIPERIDINOL;（S）-N-BOC-3-piperidinol

CBNumber:: CB6197360

Molecular Formula:: C10H19NO3

Molecular Weight:: 201.26

MDL Number:: MFCD06659041

MOL File:: 143900-44-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:35:33

Product description	Number	Pack Size	Price
(S)-1-Boc-3-hydroxypiperidine 97%	687367	1g	$123
(S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC)	B4446	1g	$18
(S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC)	B4446	5g	$51
(S)-1-N-BOC-3-HYDROXY-PIPERIDINE 97%	56850	25G	$22
(S)-1-N-BOC-3-HYDROXY-PIPERIDINE 97%	56850	100G	$59
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(S)-1-Boc-3-hydroxypiperidine Properties

Melting point	34-40 °C
Boiling point	292.3±33.0 °C(Predicted)
Density	1.107±0.06 g/cm3(Predicted)
Flash point	110 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in methanol.
pka	14.74±0.20(Predicted)
form	Powder or Crystalline Powder
color	White to tan
optical activity	[α]22/D +10.0°, c = 1 in chloroform
InChI	InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1
InChIKey	UIJXHKXIOCDSEB-QMMMGPOBSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1
CAS DataBase Reference	143900-44-1(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39

WGK Germany

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

REACH Registrations

Active

NFPA 704

	1
2		0

(S)-1-Boc-3-hydroxypiperidine price More Price(60)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	687367	(S)-1-Boc-3-hydroxypiperidine 97%	143900-44-1	1g	$123	2026-04-30	Buy
TCI Chemical	B4446	(S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC)	143900-44-1	1g	$18	2026-04-30	Buy
TCI Chemical	B4446	(S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC)	143900-44-1	5g	$51	2026-04-30	Buy
AstaTech	56850	(S)-1-N-BOC-3-HYDROXY-PIPERIDINE 97%	143900-44-1	25G	$22	2026-04-30	Buy
AstaTech	56850	(S)-1-N-BOC-3-HYDROXY-PIPERIDINE 97%	143900-44-1	100G	$59	2026-04-30	Buy

Product number	Packaging	Price	Buy
687367	1g	$123	Buy
B4446	1g	$18	Buy
B4446	5g	$51	Buy
56850	25G	$22	Buy
56850	100G	$59	Buy

(S)-1-Boc-3-hydroxypiperidine Chemical Properties,Uses,Production

Uses

(S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.

Description

(S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield.

Chemical Properties

White powder

Uses

A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.

Uses

(S)-1-Boc-3-hydroxypiperidine is used as pharmaceutical intermediate.

(S)-1-Boc-3-hydroxypiperidine synthesis

Synthesis of (S)-1-Boc-3-hydroxypiperidine from 1-Boc-3-piperidone

(S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-3-Hydroxypiperidine hydrochloride (3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine (S)-3-Methoxypiperidine (S)-3-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester (S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE

(S)-1-Boc-3-hydroxypiperidine Suppliers

Global( 617)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SyncoZymes (Shanghai) Co., Ltd.,	+8613681683526	lchen@syncozymes.com	China	286	58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.	+86-18616643091	info@rochipharma.com	China	246	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1006	58
Hebei Ganmiao New material Technology Co., LTD	+86-17332992504	sales8@hbganmiao.com	China	300	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60

Supplier	Advantage
SyncoZymes (Shanghai) Co., Ltd.,	58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Hangzhou ICH Biofarm Co., Ltd	58
Hebei Ganmiao New material Technology Co., LTD	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60

Synthetic Method and FTIR analysis of (S)-1-Boc-3-hydroxypiperidine
(S)-1-Boc-3-hydroxypiperidine serves as an important chiral intermediate in the synthesis of ibrutinib, an anticancer drug tar....
Mar 13，2026

Uses and Preparation of (S)-1-Boc-3-hydroxypiperidine
As a piperidine derivative, (S)-1-tert-butoxycarbonyl-3-hydroxypiperidine (1) is an important intermediate with a chiral struc....
Jul 11，2022

View Lastest Price from (S)-1-Boc-3-hydroxypiperidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-29	(S)-1-Boc-3-hydroxypiperidine 143900-44-1	US $63.00-308.00 / g	100g	0.99	100kg	Shanghai UCHEM Inc.
2026-01-04	(S)-1-Boc-3-hydroxypiperidine 143900-44-1	US $0.00-0.00 / kg	1kg	99.9%	20 tons	Hangzhou ICH Biofarm Co., Ltd
2025-12-01	(S)-1-Boc-3-hydroxypiperidine 143900-44-1	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

(S)-1-Boc-3-hydroxypiperidine
143900-44-1
US $63.00-308.00 / g
0.99
Shanghai UCHEM Inc.

(S)-1-Boc-3-hydroxypiperidine
143900-44-1
US $0.00-0.00 / kg
99.9%
Hangzhou ICH Biofarm Co., Ltd

(S)-1-Boc-3-hydroxypiperidine
143900-44-1
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

(S)-1-Boc-3-hydroxypiperidine Spectrum

(S)-1-Boc-3-hydroxypiperidine(143900-44-1)¹HNMR

143900-44-1((S)-1-Boc-3-hydroxypiperidine)Related Search:

3-Hydroxypiperidine tert-Butyl acetate (R)-1-BOC-3-HYDROXYPIPERIDINE,(R)-1-N-BOC-3-HYDROXYPIPERIDINE,(R)-N-BOC-3-HYDROXYPIPERIDINE tert-Butyl peroxyacetate Haloperidol

Btk inhibitor 1 (R enantioMer hydrochloride) Ibrutinib Impurity 21 tert-Butanol N-BOC-2-HYDROXYPIPERIDINE (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one

Ibrutinib Impurity 24 Ibrutinib (S)-Ibrutinib (S)-3-Hydroxypiperidine Ibrutinib Dimer Impurity

Ibrutinib Impurity 28 Ibrutinib Impurity 25 Acrylic anhydride

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(S)-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE (S)-1-BOC-3-HYDROXYPIPERIDINE (S)-1-BOC-3-PIPERIDINOL (S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPIPERIDINE HYDROCHLORIDE (S)-N-BOC-3-HYDROXY PIPERIDINE (S)-TERT BUTYL-3-HYDROXYPIPERIDINE-1-CARBOXYLATE 1-PIPERIDINECARBOXYLIC ACID, 3-HYDROXY-, 1,1-DIMETHYLETHYL ESTER, (3S)- (S)-1-Boc-3-hydroxypiperidine 97% 15. (S)-tert-butyl 3-hydroxypiperidine-1-carboxylate1 tert-butyl (S)-3-hydroxypiperidine-1-carboxylate143900-44-1 (S)-1-BOC-3-HYDROXYPIPERIDINE 3PC-20160102 [REJECTED MATERIAL IS SENDING BACK TOYOU DUE TO FAILED IN QUALITY PARAMETERS (S)-N-Boc-3-hydroxypiperidine,98%e.e. (S)-1-Boc-3-Hdroxypiperidine (S)-1-Boc-3-hydroxypiperi... tert-Butyl (3S)-3-hydroxypiperidine-1-carboxylate, (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine (S)-tert-butyl 3-hydroxypiperidin-1-carboxylate (3S)-3-Hydroxy-1-piperidinecarboxylic Acid 1,1-diMethylethyl Ester 1,1-DiMethylethy tert- butyl (3S)-3-hydroxy piperidine-1-carboxylate (3S)-hydroxy-1-piperidinecarboxylic acid 1,1-diMethylethyl ester (S)-1-Boc-3-hydroxypiperidine,97% (S)-1-Boc-3-hydroxypiperidine (S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine (S)-1-N-BOC-3-HYDROXY-PIPERIDINE (S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine (S)-3-Hydroxypiperidine, N-BOC protected (S)-1-BOC-Piperidin-3-ol (S)-1-Boc-3-hydroxypiperidine,(S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate (3S)-3-Hydroxypiperidine, N-BOC protected (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine > (S)-1-tert-butyrolactone-3-hydroxypiperidine （S）-N-BOC-3-piperidinol (S)-1-Boc-4-hydroxypiperidine (S) -1-tert-butyloxycarbonyl-3-hydroxypiperidine (S)-1-BOC-3-HYDROXYPIPERIDINE, IBRUTINIB INT (S)-1-Boc-3-hydroxypiperidine ISO 9001：2015 REACH Ibrutinib Interm 0441 (S)-BOC-piperidinol Thieno[2,3-c]pyridine-3-carboxylicacid,2-amino-4,5,6,7-tetrahydro-8-(phenylmethyl)-,ethylester Carbamicacid,N-[2-(2-hydroxyethoxy)ethyl]-,1,6-dimethylethylester 1-Piperidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (3S)- (9CI, ACI) 3-hydroxy-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester (3S)- (9CI ACI) 3-Hydroxy-1-piperidinecarboxylic acid tert-butyl ester (3S)- (S) 1-tert-butoxycarbonyl-3-hydroxypyridine Ilutinib impurity 7 CAS:143900-44-1 (S)-1-Boc-3-hydroxypiperidine (S)-1-(tert-Butoxycarbonyl)-3-carboxypiperidine tert-butyl (S)-3-hydroxypiperidine-1-carboxylate (Intermediate of Ibrutinib) (S)-1-TERT-BUTOXYCARBONYL-3-HYDROXYPIPERIDINE (S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-butyl (S)-3-hydroxypiperidine-1-carboxylate 143900-44-1 14390-44-1 14390-44-1 43900-44-1 C10H19NO3HCl New Products for Chemical Synthesis May/June 2007 Piperazine

(S)-1-Boc-3-hydroxypiperidine

(S)-1-Boc-3-hydroxypiperidine Properties

SAFETY

Risk and Safety Statements

(S)-1-Boc-3-hydroxypiperidine price More Price(60)

(S)-1-Boc-3-hydroxypiperidine Chemical Properties,Uses,Production

Uses

Description

Chemical Properties

Uses

Uses

(S)-1-Boc-3-hydroxypiperidine synthesis

(S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-1-Boc-3-hydroxypiperidine Suppliers

Related articles

View Lastest Price from (S)-1-Boc-3-hydroxypiperidine manufacturers

(S)-1-Boc-3-hydroxypiperidine Spectrum

143900-44-1((S)-1-Boc-3-hydroxypiperidine)Related Search: