(S)-1-Boc-3-hydroxypiperidine
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(S)-1-Boc-3-hydroxypiperidine 속성
- 녹는점
- 34-40 °C
- 끓는 점
- 292.3±33.0 °C(Predicted)
- 밀도
- 1.107±0.06 g/cm3(Predicted)
- 인화점
- 110 °C
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 메탄올에 용해됩니다.
- 산도 계수 (pKa)
- 14.74±0.20(Predicted)
- 물리적 상태
- 분말 또는 결정성 분말
- 색상
- 흰색에서 황갈색까지
- ??? (Optical Rotation)
- [α]22/D +10.0°, c = 1 in chloroform
- InChI
- InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1
- InChIKey
- UIJXHKXIOCDSEB-QMMMGPOBSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1
- CAS 데이터베이스
- 143900-44-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36/37/39 | ||
| WGK 독일 | 3 | ||
| HS 번호 | 29339900 |
(S)-1-Boc-3-hydroxypiperidine C화학적 특성, 용도, 생산
개요
(S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield.화학적 성질
White powder용도
A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.(S)-1-Boc-3-hydroxypiperidine 준비 용품 및 원자재
원자재
준비 용품
(S)-1-Boc-3-hydroxypiperidine 공급 업체
글로벌( 620)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| SyncoZymes (Shanghai) Co., Ltd., | +8613681683526 |
lchen@syncozymes.com | China | 188 | 58 |
| Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +86-18616643091 |
info@rochipharma.com | China | 246 | 58 |
| Lianhe Aigen Pharmatech Co.,Ltd. | +86-18918657159; +undefined+undefined18918657159 |
sales@lianhe-aigen.com | China | 317 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49975 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 |
sales@ichemie.com | China | 1014 | 58 |
| Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 |
sales8@hbganmiao.com | China | 300 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +86-17709210191; +8617709210191 |
Jerry@xhobio.com | China | 883 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 |
niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 |
sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 |
info@dakenam.com | China | 13090 | 58 |
(S)-1-Boc-3-hydroxypiperidine 관련 검색:
터트-부틸 퍼옥시아세테이트 할로페리돌 tert-부틸알코올 3-히드록시피페리딘 삼차부틸 아세트산 N-BOC-2-하이드록시피페리딘 이브루티니브 (S)-이브루티닙 (S)-3-히드록시피페리딘 아크릴무수물 4-(4-메틸피페라진-1-일메틸)벤조산 이브루티닙불순물3 ImatinibMeta-methyl-piperazine불순물 N-(3-GUANIDINO-4-메틸페닐)-4-(메틸피페라진-1-YL-메틸)벤즈아미드 iMatinib관련물질C 1-피페리딘카르복실산,3-[4-a미노-3-(4-페녹시페닐)-1H-피라졸로[3,4-d]피리미딘-1-일]-,1,1-디메틸에틸에스테르,(3R)- 3-하이드록시피페리딘 수화염화물 디페