8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester
![8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester Structure](CAS/GIF/96428-50-1.gif)
- CAS No.
- 96428-50-1
- Chemical Name:
- 8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester
- Synonyms
- 2-carboethoxy-3-methyl-8-(phenylmethoxy)imidazo<1,2-a>pyridine;Imidazo[1,2-a]pyridine-3-carboxylicacid, 2-methyl-8-(phenylm...;Ethyl 8-(Benzyloxy)-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate;Ethyl 8-(benzyloxy)-2-MethylH-iMidazo[1,2-a]pyridine-3-carboxylate;ethyl 2-methyl-8-phenylmethoxyimidazo[1,2-a]pyridine-3-carboxylate;8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester;2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester;Imidazo[1,2-a]pyridine-3-carboxylic acid, 2-methyl-8-(phenylmethoxy)-, ethyl ester
- CBNumber:
- CB6198736
- Molecular Formula:
- C18H18N2O3
- Molecular Weight:
- 310.35
- MDL Number:
- MFCD06739215
- MOL File:
- 96428-50-1.mol
- MSDS File:
- SDS
8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | E59208 | Ethyl 8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate 95+% | 96428-50-1 | 100mg | $25 | 2026-05-06 | Buy |
| Synthonix | E59208 | Ethyl 8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate 95+% | 96428-50-1 | 250mg | $60 | 2026-05-06 | Buy |
| Synthonix | E59208 | Ethyl 8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate 95+% | 96428-50-1 | 1g | $70 | 2026-05-06 | Buy |
| Synthonix | E59208 | Ethyl 8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate 95+% | 96428-50-1 | 5g | $250 | 2026-05-06 | Buy |
| Synthonix | E59208 | Ethyl 8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate 95+% | 96428-50-1 | 10g | $1270 | 2026-05-06 | Buy |
8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester Chemical Properties, Uses, Production
Synthesis
24016-03-3
609-15-4
![8-BENZYLOXY-2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/96428-50-1.gif)
96428-50-1
Example 1A Synthesis of ethyl 8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate: 25 g (124.8 mmol) of 2-amino-3-benzyloxypyridine was dissolved in 781 ml of anhydrous ethanol, followed by the addition of 102.7 g (624.2 mmol) of ethyl 2-chloroacetoacetate and 2 tablespoons of 4A molecular sieves. The reaction mixture was heated to reflux (oil bath temperature 100 °C) for 2 days. Upon completion of the reaction, the mixture was concentrated and excess ethyl 2-chloroacetoacetate was removed by rotary evaporator under dry ice cooling conditions. The residue was purified by silica gel column chromatography with a mobile phase of cyclohexane: ethyl acetate (gradient elution from 9:1 to 4:1). Finally, 20.81 g of the target compound ethyl 2-methyl-8-(benzyloxy)imidazo[1,2-a]pyridine-3-carboxylate was obtained in 54% yield and 99% purity. The product was analyzed by LC-MS (Method 2): retention time Rt = 1.12 min, mass spectrum (ESpos): m/z = 311 (M + H)+. 1H NMR (400 MHz, DMSO-d6) data were as follows: δ= 1.35 (t, 3H), 2.59 (s, 3H), 4.34 (q, 2H), 5.32 (s, 2H). 7.01-7.09 (m, 2H), 7.33-7.48 (m, 3H), 7.52 (d, 2H), 8.81-8.86 (m, 1H).
References
[1] Patent: US2014/128386, 2014, A1. Location in patent: Paragraph 0984; 0985; 0986; 0987; 0988
[2] Patent: US2014/128372, 2014, A1. Location in patent: Paragraph 0489; 0490; 0491; 0492; 0493
[3] Patent: US2017/57954, 2017, A1. Location in patent: Paragraph 0620; 0621; 0622; 0623; 0624
[4] Patent: US2016/347770, 2016, A1. Location in patent: Paragraph 0691; 0692; 0693; 0694; 0695
[5] Journal of Medicinal Chemistry, 1985, vol. 28, # 7, p. 876 - 892
8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Cuisen Pharmaceutical Technology Co., Ltd. | 13472757003 | yongnan.wang@cendrix.cn | China | 971 | 65 |
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| Shanghai Toplab Chemical Co., Ltd. | 021-31137757-00; 18121466954;18121466954 | 28328681@qq.com | China | 184 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shandong Ono Chemical Co., Ltd. | 0539-6362799 20） | China | 9998 | 58 | |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Henan Alfachem Co.,Ltd. | 0371-55051623 18137891487 | 3983243027@qq.com | China | 9970 | 58 |
| 3A Chemicals | 400-668-9898 | service@3achem.com | China | 20535 | 58 |
| Shanghai zhigan biotechnology co., LTD | zhiqianbio@126.com | China | 19765 | 58 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25333 | 58 |
