8-BENZYLOXY-2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
![8-BENZYLOXY-2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Structure](CAS/GIF/96428-50-1.gif)
- CAS No.
- 96428-50-1
- Chemical Name:
- 8-BENZYLOXY-2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- 2-carboethoxy-3-methyl-8-(phenylmethoxy)imidazo<1,2-a>pyridine;Imidazo[1,2-a]pyridine-3-carboxylicacid, 2-methyl-8-(phenylm...;Ethyl 8-(Benzyloxy)-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate;Ethyl 8-(benzyloxy)-2-MethylH-iMidazo[1,2-a]pyridine-3-carboxylate;ethyl 2-methyl-8-phenylmethoxyimidazo[1,2-a]pyridine-3-carboxylate;8-BENZYLOXY-2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER;2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester;Imidazo[1,2-a]pyridine-3-carboxylic acid, 2-methyl-8-(phenylmethoxy)-, ethyl ester
- CBNumber:
- CB6198736
- Molecular Formula:
- C18H18N2O3
- Molecular Weight:
- 310.35
- MDL Number:
- MFCD06739215
- MOL File:
- 96428-50-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ethyl8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate | 4117AJ | 10g | $1778 |
| 8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridine-3-carboxylicacidethylester 96% | 68R0302 | 5g | $5998 |
| Ethyl8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate 95+% | A475400 | 100mg | $49 |
| Ethyl8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate 95+% | A475400 | 250mg | $71 |
| Ethyl8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate 95+% | A475400 | 1g | $178 |
| More product size | |||
8-BENZYLOXY-2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 4117AJ | Ethyl8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate | 96428-50-1 | 10g | $1778 | 2021-12-16 | Buy |
| J&W Pharmlab | 68R0302 | 8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridine-3-carboxylicacidethylester 96% | 96428-50-1 | 5g | $5998 | 2021-12-16 | Buy |
| Ambeed | A475400 | Ethyl8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate 95+% | 96428-50-1 | 100mg | $49 | 2021-12-16 | Buy |
| Ambeed | A475400 | Ethyl8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate 95+% | 96428-50-1 | 250mg | $71 | 2021-12-16 | Buy |
| Ambeed | A475400 | Ethyl8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate 95+% | 96428-50-1 | 1g | $178 | 2021-12-16 | Buy |
8-BENZYLOXY-2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Uses,Production
Synthesis
24016-03-3
609-15-4
![8-BENZYLOXY-2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/96428-50-1.gif)
96428-50-1
Example 1A Synthesis of ethyl 8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate: 25 g (124.8 mmol) of 2-amino-3-benzyloxypyridine was dissolved in 781 ml of anhydrous ethanol, followed by the addition of 102.7 g (624.2 mmol) of ethyl 2-chloroacetoacetate and 2 tablespoons of 4A molecular sieves. The reaction mixture was heated to reflux (oil bath temperature 100 °C) for 2 days. Upon completion of the reaction, the mixture was concentrated and excess ethyl 2-chloroacetoacetate was removed by rotary evaporator under dry ice cooling conditions. The residue was purified by silica gel column chromatography with a mobile phase of cyclohexane: ethyl acetate (gradient elution from 9:1 to 4:1). Finally, 20.81 g of the target compound ethyl 2-methyl-8-(benzyloxy)imidazo[1,2-a]pyridine-3-carboxylate was obtained in 54% yield and 99% purity. The product was analyzed by LC-MS (Method 2): retention time Rt = 1.12 min, mass spectrum (ESpos): m/z = 311 (M + H)+. 1H NMR (400 MHz, DMSO-d6) data were as follows: δ= 1.35 (t, 3H), 2.59 (s, 3H), 4.34 (q, 2H), 5.32 (s, 2H). 7.01-7.09 (m, 2H), 7.33-7.48 (m, 3H), 7.52 (d, 2H), 8.81-8.86 (m, 1H).
References
[1] Patent: US2014/128386, 2014, A1. Location in patent: Paragraph 0984; 0985; 0986; 0987; 0988
[2] Patent: US2014/128372, 2014, A1. Location in patent: Paragraph 0489; 0490; 0491; 0492; 0493
[3] Patent: US2017/57954, 2017, A1. Location in patent: Paragraph 0620; 0621; 0622; 0623; 0624
[4] Patent: US2016/347770, 2016, A1. Location in patent: Paragraph 0691; 0692; 0693; 0694; 0695
[5] Journal of Medicinal Chemistry, 1985, vol. 28, # 7, p. 876 - 892
8-BENZYLOXY-2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Nanjing Hengbei Chemicals Co., Ltd. | +86-25-58393656 | sales@hengbeichem.cn | China | 6854 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5899 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| shanghai Rainbow MediTech.Co.Ltd. | 021-64968085,64968086-5815,5812; 13472757003 | xiaoxia.zeng@rainbowpharma.cn | China | 961 | 65 |
| Nantong Bosu Pharmaceutical Technology Co., Ltd. | 0513-0513-51005092 13390947892 | tashiyxy@163.com | China | 806 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 17321281695 18019252918 | sale@amkchem.com | China | 15114 | 55 |
| Shanghai Toplab Chemical Co., Ltd. | 021-31137757-00; 18121466954 | 28328681@qq.com | China | 181 | 55 |
| Shandong Ono Chemical Co., Ltd. | 0539-6362799 20） | China | 9998 | 58 |
