Benzyl N-(2-hydroxyethyl)carbamate
- CAS No.
- 77987-49-6
- Chemical Name:
- Benzyl N-(2-hydroxyethyl)carbamate
- Synonyms
- Benzyl (2-hydroxyethyl)carbaMate;2-(CARBOBENZOXYAMINO)-1-ETHANOL;Z-GLY-OL;Z-GLYCINOL;N-Z-ETHANOLAMINE;Cbz-Gly-OL;Z-NH-(CH2)2-OH;Z-ETHANOLAMINE;Z-AMINOETHANOL;N-CBZ-GLYCINOL
- CBNumber:
- CB6201850
- Molecular Formula:
- C10H13NO3
- Molecular Weight:
- 195.22
- MDL Number:
- MFCD00191060
- MOL File:
- 77987-49-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 58-60 °C (lit.) |
|---|---|
| Boiling point | 215 °C/15 mmHg (lit.) |
| Density | 1.1926 (rough estimate) |
| refractive index | 1.5150 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in water or 1% acetic acid |
| pka | 11.80±0.46(Predicted) |
| form | Powder |
| color | White |
| BRN | 2050891 |
| InChI | InChI=1S/C10H13NO3/c12-7-6-11-10(13)14-8-9-4-2-1-3-5-9/h1-5,12H,6-8H2,(H,11,13) |
| InChIKey | SAGINAGERRNGGV-UHFFFAOYSA-N |
| SMILES | C(OCC1=CC=CC=C1)(=O)NCCO |
| CAS DataBase Reference | 77987-49-6(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29221985 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Benzyl N-(2-hydroxyethyl)carbamate price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 407909 | N-Z-Ethanolamine 98% | 77987-49-6 | 5g | $35 | 2023-06-20 | Buy |
| Sigma-Aldrich | 407909 | N-Z-Ethanolamine 98% | 77987-49-6 | 25g | $40 | 2023-06-20 | Buy |
| TCI Chemical | H0793 | 2-(Carbobenzoxyamino)-1-ethanol >97.0%(GC) | 77987-49-6 | 5g | $62 | 2026-04-30 | Buy |
| TCI Chemical | H0793 | 2-(Carbobenzoxyamino)-1-ethanol >97.0%(GC) | 77987-49-6 | 25g | $244 | 2026-04-30 | Buy |
| Usbiological | 457370 | N-(Benzyloxycarbonyl)ethanolamine | 77987-49-6 | 1g | $312 | 2026-06-03 | Buy |
Benzyl N-(2-hydroxyethyl)carbamate Chemical Properties,Uses,Production
Chemical Properties
White powder
Uses
N-(Benzyloxycarbonyl)ethanolamine is an intermediate used to prepare alkynylaryladenines as A2A adenosine receptor agonists and effects on hepatic glucose production. It is also used in the synthesis of functionalized N-arylaminoethyl amides as noncovalent inhibitors of cathepsin S.
reaction suitability
reagent type: cross-linking reagent
Synthesis
141-43-5
501-53-1
77987-49-6
(1) Synthesis of benzyl [2-(tert-butyldiphenylmethoxysilyl)ethyl]carbamate [1515]: To a solution of 2-aminoethanol (2.0 g, 32.7 mmol) in dichloromethane (60 mL), benzyl chloroformate (5.6 mL, 41.3 mmol) and triethylamine (5.5 mL, 39.5 mmol) were sequentially added under ice bath conditions. The reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the mixture was partitioned between ethyl acetate and saturated aqueous sodium chloride solution. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being toluene:acetonitrile (3:2) to afford benzyl (2-hydroxyethyl)carbamate (5.37 g, 84% yield) as a white solid. [1516] Subsequently, to a solution of benzyl (2-hydroxyethyl)carbamate (5.37 g, 27.5 mmol) in dimethylformamide (160 mL) was added tert-butyldiphenylmethylsilyl chloride (8.6 mL, 33.0 mmol) and imidazole (2.3 g, 33.8 mmol) under ice bath conditions. The mixture was stirred at room temperature overnight. After the reaction was complete, ethanol was added and stirring was continued for 2 hours. The reaction mixture was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate. The organic layer was washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with hexane:ethyl acetate (5:1) as eluent to give benzyl [2-(tert-butyldiphenylmethylsilylmethoxy)ethyl]carbamate (11.93 g, 100% yield) as a colorless transparent syrup. [1517] 1H-NMR (400 MHz, CDCl3): δ (ppm) 7.64 (4H, d, J = 6.8 Hz), 7.46-7.28 (12H, m), 5.10 (2H, s), 3.73 (2H, t, J = 4.9 Hz), 3.35 (2H, q, J = 4.9 Hz), 1.05 (9H, s).
References
[1] Patent: US2004/14962, 2004, A1. Location in patent: Page/Page column 137
[2] Journal of Organic Chemistry, 1987, vol. 52, # 7, p. 1252 - 1255
[3] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 15, p. 1749 - 1750
[4] Tetrahedron Letters, 2007, vol. 48, # 46, p. 8170 - 8173
[5] Tetrahedron, 1991, vol. 47, # 14/15, p. 2591 - 2602
Benzyl N-(2-hydroxyethyl)carbamate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Cheminspire Technology Co., Ltd. | 0571-89081561; 10006559855 | info@cheminspire.com | China | 412 | 58 |
| Taizhou Wealsun Biotech Co., Ltd | 18351140886; 18351140886 | wealsunbio@126.com | China | 139 | 58 |
| Chengdu jingzhihuacheng Chemical Technology Co., Ltd. | 028-37664989 15900794981 | 873239557@qq.com | China | 1050 | 58 |
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 423 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
View Lastest Price from Benzyl N-(2-hydroxyethyl)carbamate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Cbz-Gly-ol
77987-49-6
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2025-04-04 | BENZYL N-(2-HYDROXYETHYL)CARBAMATE
77987-49-6
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2020-01-06 | Z-Gly-ol
77987-49-6
|
$1.00 | 1g | 98% | 100KG | Sichuan Jiaying Lai Technology Co.,LTD |
-
- Cbz-Gly-ol
77987-49-6
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- BENZYL N-(2-HYDROXYETHYL)CARBAMATE
77987-49-6
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Z-Gly-ol
77987-49-6
- $1.00
- 98%
- Sichuan Jiaying Lai Technology Co.,LTD
