Z-Aib-OH
- CAS No.
- 15030-72-5
- Chemical Name:
- Z-Aib-OH
- Synonyms
- Z-Aib;2-[(Benzyloxycarbonyl)amino]-2-methylpropanoic acid;Cbz-Aib;Z-Aib-OH;Cbz-Aib-OH;NSC 164086;Z-AIB-OH,98%;Cbz-L-Aib-OH;N-CBZ-AIB-OH;Z-a-Me-Ala-OH
- CBNumber:
- CB7448841
- Molecular Formula:
- C12H15NO4
- Molecular Weight:
- 237.25
- MDL Number:
- MFCD00004190
- MOL File:
- 15030-72-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 65-69 °C(lit.) |
|---|---|
| Boiling point | 379.78°C (rough estimate) |
| Density | 1.215 |
| refractive index | 1.5200 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | soluble in Methanol |
| form | Powder |
| pka | 4.09±0.10(Predicted) |
| color | White |
| BRN | 2218009 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C12H15NO4/c1-12(2,10(14)15)13-11(16)17-8-9-6-4-3-5-7-9/h3-7H,8H2,1-2H3,(H,13,16)(H,14,15) |
| InChIKey | QKVCSJBBYNYZNM-UHFFFAOYSA-N |
| SMILES | C(O)(=O)[C@](C)(C)NC(OCC1=CC=CC=C1)=O |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 24/25-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Z-Aib-OH price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 370940 | Z-Aib-OH technical grade | 15030-72-5 | 5g | $64.2 | 2026-04-30 | Buy |
| TCI Chemical | C2761 | 2-(Carbobenzoxyamino)isobutyric Acid >98.0%(HPLC)(T) | 15030-72-5 | 5g | $24 | 2026-04-30 | Buy |
| TCI Chemical | C2761 | 2-(Carbobenzoxyamino)isobutyric Acid >98.0%(HPLC)(T) | 15030-72-5 | 25g | $70 | 2026-04-30 | Buy |
| Usbiological | 260717 | Z-alpha-aminoisobutyric acid Asreported | 15030-72-5 | 2g | $333 | 2026-06-03 | Buy |
| Usbiological | 260717 | Z-alpha-aminoisobutyric acid Asreported | 15030-72-5 | 5g | $496 | 2026-06-03 | Buy |
Z-Aib-OH Chemical Properties, Uses, Production
Chemical Properties
white powder
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
62-57-7
501-53-1
15030-72-5
The general procedure for the synthesis of Cbz-2-aminoisobutyric acid from 2-aminoisobutyric acid and benzyl chloroformate was as follows: to an aqueous solution (1 L) containing 2-aminoisobutyric acid (50 g, 0.49 mmol) and sodium carbonate (Na2CO3, 156 g, 1.47 mol), benzyl chloroformate (CbzCl, 91 g, 1.47 mmol) was slowly added over 15 min at 0 °C. 0.54 mmol) to a dioxane solution (500 mL). The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the aqueous layer was separated and retained by extraction with ether (Et2O, 2 x 500 mL). The aqueous layer was acidified with concentrated hydrochloric acid (cHCl) to pH=1 and then extracted with ethyl acetate (EtOAc, 2 × 500 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford a white solid Cbz-2-aminoisobutyric acid (111 g, 97% yield), which could be used for the next reaction without further purification.
References
[1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 2, p. 533 - 548
[2] Patent: WO2013/114250, 2013, A1. Location in patent: Page/Page column 163
[3] Helvetica Chimica Acta, 2011, vol. 94, # 6, p. 993 - 1011
[4] Tetrahedron, 1982, vol. 38, # 14, p. 2165 - 2182
[5] Helvetica Chimica Acta, 1988, vol. 71, p. 140 - 154
Z-Aib-OH Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 15366717810 | sales@thbiochem.com | China | 407 | 55 |
| Shanghai Chiral Chemicals Inc. | 021-37285021 13472570865 | tym7xi@aliyun.com | China | 299 | 64 |
| Wudi Rongchuan Pharmaceutical and Chemical Technology Co., Ltd. | 021-5147-3705 17852115892 | wxj@yananpharm.com | China | 64 | 58 |
| Shan Dong FengJin Pharmaceutical Co.,Ltd. | 18364437686 18364437686 | 15066764791@163.com | China | 33 | 58 |
| Nanjing Danron Bio-New Materials Co.Ltd | 18936428028 18936428028 | 3806853067@qq.com | China | 147 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Sichuan Tongsheng Amino acids Co.,Ltd. | 0838-2274206 17340404235 | sales@biots.cn | China | 300 | 66 |
