Z-AIB-OH
- CAS No.
- 15030-72-5
- Chemical Name:
- Z-AIB-OH
- Synonyms
- Z-Aib;Z-AIB-OH;Cbz-Aib-OH;NSC 164086;Z-AIB-OH,98%;Cbz-L-Aib-OH;Z-a-Me-Ala-OH;N-Cbz-2-methyL;Z-ALPHA-ME-ALA-OH;Z-2-METHYLALANINE
- CBNumber:
- CB7448841
- Molecular Formula:
- C12H15NO4
- Molecular Weight:
- 237.25
- MDL Number:
- MFCD00004190
- MOL File:
- 15030-72-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Z-Aib-OH technical grade | 370940 | 5g | $60.3 |
| 2-(Carbobenzoxyamino)isobutyric Acid >98.0%(HPLC)(T) | C2761 | 5g | $36 |
| 2-(Carbobenzoxyamino)isobutyric Acid >98.0%(HPLC)(T) | C2761 | 25g | $105 |
| N-Cbz-2-amino-2-methylpropanoicAcid | C227943 | 500mg | $75 |
| Z-alpha-aminoisobutyric acid | 260717 | 2g | $333 |
| More product size | |||
| Melting point | 65-69 °C(lit.) |
|---|---|
| Boiling point | 379.78°C (rough estimate) |
| Density | 1.215 |
| refractive index | 1.5200 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | soluble in Methanol |
| pka | 4.09±0.10(Predicted) |
| form | Powder |
| color | White |
| BRN | 2218009 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C12H15NO4/c1-12(2,10(14)15)13-11(16)17-8-9-6-4-3-5-7-9/h3-7H,8H2,1-2H3,(H,13,16)(H,14,15) |
| InChIKey | QKVCSJBBYNYZNM-UHFFFAOYSA-N |
| SMILES | C(O)(=O)[C@](C)(C)NC(OCC1=CC=CC=C1)=O |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 24/25-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Z-AIB-OH price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 370940 | Z-Aib-OH technical grade | 15030-72-5 | 5g | $60.3 | 2025-07-31 | Buy |
| TCI Chemical | C2761 | 2-(Carbobenzoxyamino)isobutyric Acid >98.0%(HPLC)(T) | 15030-72-5 | 5g | $36 | 2025-07-31 | Buy |
| TCI Chemical | C2761 | 2-(Carbobenzoxyamino)isobutyric Acid >98.0%(HPLC)(T) | 15030-72-5 | 25g | $105 | 2025-07-31 | Buy |
| TRC | C227943 | N-Cbz-2-amino-2-methylpropanoicAcid | 15030-72-5 | 500mg | $75 | 2021-12-16 | Buy |
| Usbiological | 260717 | Z-alpha-aminoisobutyric acid | 15030-72-5 | 2g | $333 | 2021-12-16 | Buy |
Z-AIB-OH Chemical Properties,Uses,Production
Chemical Properties
white powder
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
62-57-7
501-53-1
15030-72-5
The general procedure for the synthesis of Cbz-2-aminoisobutyric acid from 2-aminoisobutyric acid and benzyl chloroformate was as follows: to an aqueous solution (1 L) containing 2-aminoisobutyric acid (50 g, 0.49 mmol) and sodium carbonate (Na2CO3, 156 g, 1.47 mol), benzyl chloroformate (CbzCl, 91 g, 1.47 mmol) was slowly added over 15 min at 0 °C. 0.54 mmol) to a dioxane solution (500 mL). The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the aqueous layer was separated and retained by extraction with ether (Et2O, 2 x 500 mL). The aqueous layer was acidified with concentrated hydrochloric acid (cHCl) to pH=1 and then extracted with ethyl acetate (EtOAc, 2 × 500 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford a white solid Cbz-2-aminoisobutyric acid (111 g, 97% yield), which could be used for the next reaction without further purification.
References
[1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 2, p. 533 - 548
[2] Patent: WO2013/114250, 2013, A1. Location in patent: Page/Page column 163
[3] Helvetica Chimica Acta, 2011, vol. 94, # 6, p. 993 - 1011
[4] Tetrahedron, 1982, vol. 38, # 14, p. 2165 - 2182
[5] Helvetica Chimica Acta, 1988, vol. 71, p. 140 - 154
Z-AIB-OH Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Nanjing Fred Technology Co., Ltd. | +86-02584696168 15380713688 | Austin@fredchem.cn | CHINA | 865 | 58 |
| GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 |
