(2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- CAS No.
- 116026-99-4
- Chemical Name:
- (2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- Synonyms
- tert-butyl N-(2-formylpyridin-3-yl)carbamate;Boc - 3 - aMinopicolinaldehyde;TERT-BUTYL 2-FORMYLPYRIDIN-3-YLCARBAMATE;(tert-butoxy)-N-(2-forMyl(2-pyridyl)-carboxaMide;3-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXALDEHYDE;3-TERT-BUTYROXCARBONYLAMINE-PYRIDINE-2-CARBOXALDEHYDE;(2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER;N-(5-formyl-2-pyridinyl)carbamic acid tert-butyl ester;(2-Formylpyridin-3-yl)-carbamic acid tert-butyl ester ,97%;Carbamic acid, N-(2-formyl-3-pyridinyl)-, 1,1-dimethylethyl ester
- CBNumber:
- CB6203258
- Molecular Formula:
- C11H14N2O3
- Molecular Weight:
- 222.24
- MDL Number:
- MFCD04035594
- MOL File:
- 116026-99-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (2-Formyl-pyridin-3-yl)-carbamic acid tert-butyl ester Aldrich | ADE000286 | 1g | $276 |
| (2-Formyl-pyridin-3-yl)-carbamic acidtert-butyl ester | 016071 | 500.00mg | $100 |
| tert-butyl 2-formylpyridin-3-ylcarbamate 95% | U132248 | 1G | $165 |
| tert-butyl 2-formylpyridin-3-ylcarbamate 95% | U132248 | 5G | $505 |
| tert-butyl 2-formylpyridin-3-ylcarbamate 95% | U132248 | 25G | $2020 |
| More product size | |||
| Melting point | 79.4-79.6°C |
|---|---|
| Boiling point | 295.0±25.0 °C(Predicted) |
| Density | 1.212±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 12.42±0.70(Predicted) |
| color | Light Yellow |
| InChI | InChI=1S/C11H14N2O3/c1-11(2,3)16-10(15)13-8-5-4-6-12-9(8)7-14/h4-7H,1-3H3,(H,13,15) |
| InChIKey | AHTZIHDCJWVLKK-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NC1=CC=CN=C1C=O |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H317-H319 |
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22-36-43-36/37/38 |
| Safety Statements | 26-36/37-36 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29339900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Sens. 1 |
(2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000286 | (2-Formyl-pyridin-3-yl)-carbamic acid tert-butyl ester Aldrich | 116026-99-4 | 1g | $276 | 2026-04-30 | Buy |
| Matrix Scientific | 016071 | (2-Formyl-pyridin-3-yl)-carbamic acidtert-butyl ester | 116026-99-4 | 500.00mg | $100 | 2026-05-18 | Buy |
| ACHEMBLOCK | U132248 | tert-butyl 2-formylpyridin-3-ylcarbamate 95% | 116026-99-4 | 1G | $165 | 2026-05-27 | Buy |
| ACHEMBLOCK | U132248 | tert-butyl 2-formylpyridin-3-ylcarbamate 95% | 116026-99-4 | 5G | $505 | 2026-05-27 | Buy |
| ACHEMBLOCK | U132248 | tert-butyl 2-formylpyridin-3-ylcarbamate 95% | 116026-99-4 | 25G | $2020 | 2026-05-27 | Buy |
(2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production
Chemical Properties
White to off-white solid
Synthesis
2591-86-8
116026-98-3
116026-99-4
Step 2: Synthesis of tert-butyl (2-formylpyridin-3-yl)carbamate (10b) To a solution of compound 10a (2.9 g, 10.7 mmol) in tetrahydrofuran (THF, 30 mL) was slowly added n-butyllithium (n-BuLi, 2.5 M, 8.5 mL, 21.4 mmol) at -78 °C and protected by nitrogen (N2). The reaction mixture was stirred continuously at this temperature for 1 hour. Subsequently, N-formylpiperidine (1.3 mL, 11.8 mmol) was added under fast stirring conditions. The reaction system was warmed up to 0 °C and stirring was continued for 1 hour. Upon completion of the reaction, it was partitioned with 1.5 M hydrochloric acid (HCl) solution. The pH of the aqueous layer was adjusted to 7 by addition of solid sodium carbonate (Na2CO3).The aqueous layer was extracted twice with ethyl acetate (EA), the organic layers were combined and dried with anhydrous sodium sulfate (Na2SO4). After concentration under reduced pressure, purification by column chromatography (CC, petroleum ether/ethyl acetate = 3/1) afforded the target compound 10b (1.5 g, 65% yield) as a white solid.
References
[1] Journal of Medicinal Chemistry, 1988, vol. 31, # 11, p. 2136 - 2145
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 16, p. 5032 - 5043
[3] Patent: WO2013/64231, 2013, A1. Location in patent: Page/Page column 51
(2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; 19817745290 | bd@blocksynth.com | China | 5971 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49860 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| Nanjing Moldeep Biochemical Co., Ltd. | +86-25-58282389 +86-17351037455 | inquiries@moldeep.com | China | 19999 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Pengque Chemical Technology Co., LTD | 15317013857 15901926503 | pengque01@sina.com | China | 973 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from (2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-10 | (2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
116026-99-4
|
$3.00 | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- (2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
116026-99-4
- $3.00
- 98%
- Career Henan Chemical Co
