Etretinate
- CAS No.
- 54350-48-0
- Chemical Name:
- Etretinate
- Synonyms
- Retinoid;TIGASON;Tegison;Tigasone;Etretite;ro10-9359;ETRETINATE;Etretinato;tetraenoate;ethyletrinoate
- CBNumber:
- CB6214647
- Molecular Formula:
- C23H30O3
- Molecular Weight:
- 354.48
- MDL Number:
- MFCD00866624
- MOL File:
- 54350-48-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Acitretin Related Compound B pharmaceutical secondary standard, certified reference material | PHR2919 | 100MG | $454 |
| Acitretin Related Compound B | 1011029 | 20mg | $1310 |
| Etretinate >98.0%(HPLC) | E1293 | 50mg | $119 |
| Etretinate >98.0%(HPLC) | E1293 | 250mg | $414 |
| Etretinate ≥98% | 19878 | 10mg | $36 |
| More product size | |||
| Melting point | 104-1050C |
|---|---|
| Boiling point | 447.69°C (rough estimate) |
| Density | 1.0304 (rough estimate) |
| refractive index | 1.5480 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly, Sonicated), Ethyl Acetate (Slightly) |
| form | Solid |
| color | Light Yellow to Yellow |
| Stability | Light Sensitive |
| Major Application | pharmaceutical (small molecule) |
| InChI | 1S/C23H30O3/c1-8-26-23(24)14-17(3)11-9-10-16(2)12-13-21-18(4)15-22(25-7)20(6)19(21)5/h9-15H,8H2,1-7H3/b11-9+,13-12+,16-10+,17-14+ |
| InChIKey | HQMNCQVAMBCHCO-DJRRULDNSA-N |
| SMILES | O(C)c1c(c(c(c(c1)C)\C=C\C(=C\C=C\C(=C\C(=O)OCC)\C)\C)C)C |
| CAS DataBase Reference | 54350-48-0(CAS DataBase Reference) |
| FDA UNII | 65M2UDR9AG |
| Proposition 65 List | Etretinate |
| ATC code | D05BB01 |
| EPA Substance Registry System | Etretinate (54350-48-0) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H335-H360D-H410 | |||||||||
| Precautionary statements | P201-P202-P261-P273-P302+P352-P308+P313 | |||||||||
| target organs | Respiratory system | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 2918992090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 Repr. 1A Skin Irrit. 2 STOT SE 3 |
|||||||||
| Hazardous Substances Data | 54350-48-0(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 in mice (1 day): >4000 mg/kg i.p. (Bollag); LD50 (20 day) in mice, rats (mg/kg): 1176, >2000 i.p.; >2000, >4000 orally (Kamm) | |||||||||
| NFPA 704 |
|
Etretinate price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2919 | Acitretin Related Compound B pharmaceutical secondary standard, certified reference material | 54350-48-0 | 100MG | $454 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1011029 | Acitretin Related Compound B | 54350-48-0 | 20mg | $1310 | 2026-04-30 | Buy |
| TCI Chemical | E1293 | Etretinate >98.0%(HPLC) | 54350-48-0 | 50mg | $119 | 2026-04-30 | Buy |
| TCI Chemical | E1293 | Etretinate >98.0%(HPLC) | 54350-48-0 | 250mg | $414 | 2026-04-30 | Buy |
| Cayman Chemical | 19878 | Etretinate ≥98% | 54350-48-0 | 10mg | $36 | 2026-04-30 | Buy |
Etretinate Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Originator
Tigason,Roche,UK,1981
Uses
Aromatic analog of Retinoic Acid. Immunomodulator. Antipsoriatic.
Definition
ChEBI: Etretinate is a retinoid, an enoate ester and an ethyl ester. It has a role as a keratolytic drug.
Manufacturing Process
228 g of 5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-penta-2,4-diene-1-
triphenylphosphonium bromide are introduced under nitrogen gassing into 910
ml of dimethylformamide and treated with cooling at 5°C to 10°C within 20
minutes with 17.5 g of a suspension of sodium hydride (about 50% by
weight) in mineral oil. The mixture is stirred for 1 hour at about 10°C, then
treated at 5°C to 8°C dropwise with 61.8 g of 3-formylcrotonic acid butyl
ester, heating for 2 hours at 65°C, subsequently introduced into 8 liters of ice
water, and, after the addition of 300 g of sodium chloride, thoroughly
extracted with a total of 18 liters of hexane. The extract is washed 5 times
with 1 liter of methanol/water (6:4 parts by volume) each time and 2 times
with 1.5 liter of water each time, dried over sodium sulfate and evaporated
under reduced pressure to leave 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-
dimethyl-nona-2,4,6,8-tetraen-1-oic acid butyl ester, MP 80°C to 81°C as the
residue.
125.8 g of 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-nona-2,4,6,8-
tetraen-1-oic acid butyl ester are introduced into 2,000 ml of abs. ethanol and
treated with a solution of 125.8 g of potassium hydroxide in 195 ml of water.
The mixture is heated to boiling under nitrogen gassing for 30 minutes, then
cooled, introduced into 10 liters of ice water and, after the addition of about
240 ml of concentrated hydrochloric acid (PH 2-4), thoroughly extracted with
a total of 9 liters of methylene chloride. The extract is washed with about 6
liters of water to neutrality, dried over calcium chloride and evaporated under
reduced pressure. The residue is taken up in 700 ml of hexane. The
precipitated 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-nona-2,4,6,8-
tetraen-1-oic acid melts at 228°C to 230°C.
60 g of 9-(4-methoxy -2,3,6-trimethylphenyl )-3,7-dimethyl-nona-2,4,6 8-
tetraen-1-oic acid are dissolved in 1,000 ml of acetone. After the addition of
128 g of ethyl iodide and 128 g of potassium carbonate, the solution is stirred
under nitrogen gassing for 16 hours at 55°C to 60°C and subsequently
evaporated under reduced pressure. The residue is dissolved in 1,300 ml of
petroleum ether (BP 80°C to 105°C). The 9-(4-methoxy-2,3,6-
trimethylphenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid ethyl ester
crystallizing out at -20°C, melts at 104°C to 105°C.
brand name
Tegison (Roche);Ro 10-9359;Tigasan.
Therapeutic Function
Antipsoriatic, Antitumor
World Health Organization (WHO)
Etretinate, a retinol derivative, was introduced in 1981 for the treatment of psoriasis. Its use in pregnant women has resulted in major foetal abnormalities. The manufacturer's information emphasizes that the drug is teratogenic and must not be given to women who are pregnant, and that contraceptive measures must be maintained for at least two years after discontinuation of treatment. In some countries, blood banks are advised not to accept as donors persons who have taken etretinate within the previous year.
Etretinate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 10000 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49968 | 58 |
View Lastest Price from Etretinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-25 | Etretinate
54350-48-0
|
$50.00-118.00 | 99.48% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-06-25 | Etretinate
54350-48-0
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-02-05 | Etretinate
54350-48-0
|
$1.00 | 1KG | 98%-99.9%HPLC | 100KG | Career Henan Chemical Co |
-
- Etretinate
54350-48-0
- $50.00-118.00
- 99.48%
- TargetMol Chemicals Inc.
-
- Etretinate
54350-48-0
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- Etretinate
54350-48-0
- $1.00
- 98%-99.9%HPLC
- Career Henan Chemical Co
54350-48-0(Etretinate)Related Search:
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