N-Benzyltropinone
- CAS No.
- 28957-72-4
- Chemical Name:
- N-Benzyltropinone
- Synonyms
- 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE;8-BENZYL-8-AZABICYCLO[3.2.1]OCTAN-3-ONE;N-BENZYLNORTROPINONE;N-benzyltropinone;Atropine Impurity 85;N-Benzyltropinone,96%;8-BENZYLNORTROPAN-3-ONE;N-Benzyl-3-nortropinone;8-Benzyl-3-nortropanone;N-Benzylnortropinone >
- CBNumber:
- CB6242602
- Molecular Formula:
- C14H17NO
- Molecular Weight:
- 215.29
- MDL Number:
- MFCD00151640
- MOL File:
- 28957-72-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 28-29°C |
|---|---|
| Boiling point | 134-137°C/0.4 mm |
| Density | 1.140±0.06 g/cm3(Predicted) |
| refractive index | 1.556 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Dichloromethane, Methanol |
| form | Solid |
| pka | 7.98±0.20(Predicted) |
| color | Off-White to Pale Yellow |
| InChI | InChI=1S/C14H17NO/c16-14-8-12-6-7-13(9-14)15(12)10-11-4-2-1-3-5-11/h1-5,12-13H,6-10H2 |
| InChIKey | RSUHKGOVXMXCND-UHFFFAOYSA-N |
| SMILES | C12N(CC3=CC=CC=C3)C(CC1)CC(=O)C2 |
| CAS DataBase Reference | 28957-72-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 23-26-36/37/39-45 | |||||||||
| RIDADR | UN1760 | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 29299090 | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
N-Benzyltropinone price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4058 | N-Benzylnortropinone >95.0%(GC)(T) | 28957-72-4 | 1g | $30 | 2026-04-30 | Buy |
| TCI Chemical | B4058 | N-Benzylnortropinone >95.0%(GC)(T) | 28957-72-4 | 5g | $76 | 2026-04-30 | Buy |
| TRC | TRC-B285810-500MG | N-Benzyl Nortropinone | 28957-72-4 | 500mg | $65 | 2026-06-03 | Buy |
| TRC | TRC-B285810-2G | N-Benzyl Nortropinone | 28957-72-4 | 2g | $84 | 2026-06-03 | Buy |
| TRC | TRC-B285810-1G | N-Benzyl Nortropinone | 28957-72-4 | 1g | $72 | 2026-06-03 | Buy |
N-Benzyltropinone Chemical Properties,Uses,Production
Chemical Properties
Off-White to Pale Yellow Low-Melting Solid
Uses
An intermediate for the preparation of β-Cocaine, opioid receptor antagonists, and CCR-5 receptor antagonists
Synthesis
542-05-2
100-46-9
28957-72-4
1. To a non-homogeneous solution of 2,5-dimethoxytetrahydrofuran (82.2 g, 0.622 mol) in water (170 mL) was slowly added concentrated hydrochloric acid (30 mL) under stirring conditions. 2. In another flask, benzylamine (100 g, 0.933 mol) was dissolved in water (350 mL), cooled to 0 °C (ice bath) and concentrated hydrochloric acid (92 mL) was added slowly. 3. The 2,5-dimethoxytetrahydrofuran solution was stirred for 20 minutes and diluted with water (250 mL), followed by the sequential addition of the benzylamine solution, an aqueous (400 mL) solution of 1,3-acetone dicarboxylic acid (100 g, 0.684 mol), and an aqueous (200 mL) solution of sodium hydrogensulphate (44 g, 0.31 mol). 4. the pH of the reaction mixture was adjusted from 1 to about 4.5 using a 40% NaOH solution. 5. The resulting cloudy light yellow solution was stirred overnight. 6. The solution was acidified from pH 7.5 to 3 with 50% hydrochloric acid, heated to 85°C and stirred for 2 hours. 7. After cooling to room temperature, the solution was alkalized to pH 12 with 40% NaOH solution and extracted with dichloromethane (3 x 500 mL). 8. The organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the title intermediate as a viscous brown oil (~95% purity based on HPLC analysis). 9. The structure of the product was confirmed by 1H-NMR (CDCl3) and mass spectrometry ([M+H]+ C14H17NO calculated value 216.14; measured value 216.0).
References
[1] Patent: US2006/135764, 2006, A1. Location in patent: Page/Page column 22-23
[2] Patent: US2006/100426, 2006, A1. Location in patent: Page/Page column 18
[3] Patent: US2006/199839, 2006, A1. Location in patent: Page/Page column 23
[4] Patent: US2007/167442, 2007, A1. Location in patent: Page/Page column 40
[5] Patent: US2007/219278, 2007, A1. Location in patent: Page/Page column 15
N-Benzyltropinone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Mediking Biopharm Co., Ltd | 010-81769521,89753524,81760121 15901403431 | sales01@mediking.cn | China | 100 | 68 |
| Wuhan EnTai Technology Development Co,.Ltd | 86-27-82330560 | 2536851935@qq.com | China | 346 | 69 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Suzhou Chireach Biomedical Technology Co., Ltd. | 0512-65856968 | sales@chireach.com | China | 59 | 70 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
View Lastest Price from N-Benzyltropinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-17 | N-Benzylnortropinone
28957-72-4
|
1kg | 99% | 2 t | Beijing Mediking Biopharm Co., Ltd | ||
 |
2026-06-30 | N-Benzyltropinone
28957-72-4
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-06-20 | N-Benzyltropinone
28957-72-4
|
1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. |
-
- N-Benzylnortropinone
28957-72-4
- $0.00
- 99%
- Beijing Mediking Biopharm Co., Ltd
-
- N-Benzyltropinone
28957-72-4
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- N-Benzyltropinone
28957-72-4
- $0.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
