2,5-Dimethoxytetrahydrofuran
- CAS No.
- 696-59-3
- Chemical Name:
- 2,5-Dimethoxytetrahydrofuran
- Synonyms
- DMTHF;DIMETHOXYTETRAHYDROFURAN;TETRAHYDRO-2,5-DIMETHOXYFURAN;5-DiMethoxytetrahydrofuran;cis,trans-2,5-Dimethoxytetrahydrofuran;Protectol DMT;Dimethoxytetrahydr;2,5-Dimethoxytetrahy;Atropine Impurity 15;2,5-DIMETHOXYTETRAHYDROFURAN
- CBNumber:
- CB6728092
- Molecular Formula:
- C6H12O3
- Molecular Weight:
- 132.16
- MDL Number:
- MFCD00005359
- MOL File:
- 696-59-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -45 °C |
|---|---|
| Boiling point | 145-147 °C(lit.) |
| Density | 1.023 g/mL at 20 °C(lit.) |
| vapor pressure | 5 hPa (20 °C) |
| refractive index |
n |
| Flash point | 95 °F |
| storage temp. | Store below +30°C. |
| solubility | 300g/l |
| form | Liquid |
| color | Clear colorless to slightly yellow |
| PH | 5 (300g/l, H2O, 20℃) |
| explosive limit | 2.0-12.3%(V) |
| Water Solubility | 350 g/L (20 ºC) |
| Sensitive | Air & Light Sensitive |
| BRN | 104261 |
| InChI | 1S/C6H12O3/c1-7-5-3-4-6(8-2)9-5/h5-6H,3-4H2,1-2H3 |
| InChIKey | GFISDBXSWQMOND-UHFFFAOYSA-N |
| SMILES | COC1CCC(OC)O1 |
| LogP | 0.34 at 20℃ |
| CAS DataBase Reference | 696-59-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Furan, tetrahydro-2,5-dimethoxy-(696-59-3) |
| EPA Substance Registry System | Furan, tetrahydro-2,5-dimethoxy- (696-59-3) |
| UNSPSC Code | 12352112 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) | ![]() ![]() GHS02,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H315-H331 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P303+P361+P353-P304+P340+P311 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 10-36/37/38-36-20/21 | |||||||||
| Safety Statements | 26-36-36/37/39-16 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 1 | |||||||||
| Autoignition Temperature | >205 °C | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29321900 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 3 Inhalation Flam. Liq. 3 Skin Irrit. 2 |
|||||||||
| Toxicity | LD50 orally in Rabbit: 2040 mg/kg | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2,5-Dimethoxytetrahydrofuran price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D137103 | 2,5-Dimethoxytetrahydrofuran, mixture of cis and trans 98% | 696-59-3 | 100g | $73.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.02961 | 2,5-Dimethoxytetrahydrofuran (mixture of cis- and trans isomers) for synthesis | 696-59-3 | 25mL | $39.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | D137103 | 2,5-Dimethoxytetrahydrofuran, mixture of cis and trans 98% | 696-59-3 | 500g | $139 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.02961 | 2,5-Dimethoxytetrahydrofuran (mixture of cis- and trans isomers) for synthesis | 696-59-3 | 50mL | $47.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.02961 | 2,5-Dimethoxytetrahydrofuran (mixture of cis- and trans isomers) for synthesis | 696-59-3 | 250ML | $206 | 2026-04-30 | Buy |
2,5-Dimethoxytetrahydrofuran Chemical Properties, Uses, Production
Chemical Properties
Colorless to light yellow liqui
Uses
2,5-Dimethoxytetrahydrofuran is a tetrahydrofuran derivative that finds application in proteomics research and in organic synthesis. It is also used as an intermediate for atropine sulfate, which is an anticholinergic drug. Further, it acts as a precursor of butanediol. In addition to this, it is used as a photographic hardener and as disinfectant in formulations.
Synthesis
2,5-Dimethoxytetrahydrofuran is prepared by catalytic hydrogenation of 2,5-dialkoxy-2,5-dihydrofurans.
Solubility in water
Practically insoluble in H2O; soluble in MeOH, Et2O, THF.
Precautions
Flammable liquids must be stored in a cool, ventilated place. Noxious by inhalation, ingestion, or by contact with skin. Use in a fume hood.



2,5-Dimethoxytetrahydrofuran Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Royal Chemical Co., Ltd. | +86-02586655873 +86-13962173137 | marketing@royal-chem.com | China | 137 | 60 |
| ZHEJIANG ZETIAN FINE CHEMICALS CO.,LTD | 0571-87322520 19265846165 | sales@zetchem.com | China | 466 | 55 |
| Shandong Qianyuan Polymer Material Co. , Ltd. | 18678041314 18765609661 | 2547772582@qq.com | China | 989 | 58 |
| Hubei ZhongKe XinChen Technology Ltd. | 欢迎详询+微信 18827688560 | starvips@qq.com | China | 497 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Beijing Mediking Biopharm Co., Ltd | 010-81769521,89753524,81760121 15901403431 | sales01@mediking.cn | China | 100 | 68 |
View Latest Price from 2,5-Dimethoxytetrahydrofuran manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![]() |
2026-10-12 | 2,5-Dimethoxytetrahydrofuran
696-59-3
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
![]() |
2026-10-09 | 2,5-Dimethoxytetrahydrofuran
696-59-3
|
1kg | 99%min | 20tons | HANGZHOU HAILAN CHEMICAL CO.,LTD. | ||
![]() |
2026-10-09 | 2,5-Dimethoxytetrahydrofuran
696-59-3
|
1KG | 98%min | 20 Tons | WUHAN FORTUNA CHEMICAL CO., LTD |
-

- 2,5-Dimethoxytetrahydrofuran
696-59-3
- 0.99
- RongNa Biotechnology Co.,Ltd
-

- 2,5-Dimethoxytetrahydrofuran
696-59-3
- $0.00
- 99%min
- HANGZHOU HAILAN CHEMICAL CO.,LTD.
-

- 2,5-Dimethoxytetrahydrofuran
696-59-3
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
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