3-Chloro-5-fluorophenylboronic acid
- CAS No.
- 328956-61-2
- Chemical Name:
- 3-Chloro-5-fluorophenylboronic acid
- Synonyms
- AKOS BRN-0721;"328956-61-2 ";CAS:328956-61-2;3-Borono-5-fluorochlorobenzene;3-Chloro-5-fluorobenzeneboroni;3-CHLORO-5-FLUOROPHENYLBORONIC ACID;3-Chloro-5-fluorophenlyboronic acid;3-chloro-5-fluorophenylborinic acid;3-CHLORO-5-FLUOROBENZENEBORONIC ACID;3-Chloro-5-fluorobenzeneboronicacid97%
- CBNumber:
- CB6243205
- Molecular Formula:
- C6H5BClFO2
- Molecular Weight:
- 174.37
- MDL Number:
- MFCD06801741
- MOL File:
- 328956-61-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >200°C |
|---|---|
| Boiling point | 308.1±52.0 °C(Predicted) |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 6.52±0.10(Predicted) |
| color | White to Almost white |
| Water Solubility | Slightly soluble in water. |
| CAS DataBase Reference | 328956-61-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
3-Chloro-5-fluorophenylboronic acid price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2914 | 3-Chloro-5-fluorophenylboronic Acid (contains varying amounts of Anhydride) | 328956-61-2 | 1g | $42 | 2026-04-30 | Buy |
| TCI Chemical | C2914 | 3-Chloro-5-fluorophenylboronic Acid (contains varying amounts of Anhydride) | 328956-61-2 | 5g | $165 | 2026-04-30 | Buy |
| Activate Scientific | AS40342 | 3-Chloro-5-fluorophenylboronic acid 98% | 328956-61-2 | 1g | $29 | 2026-06-04 | Buy |
| Activate Scientific | AS40342 | 3-Chloro-5-fluorophenylboronic acid 98% | 328956-61-2 | 5g | $42 | 2026-06-04 | Buy |
| Activate Scientific | AS40342 | 3-Chloro-5-fluorophenylboronic acid 98% | 328956-61-2 | 25g | $95 | 2026-06-04 | Buy |
3-Chloro-5-fluorophenylboronic acid Chemical Properties, Uses, Production
Chemical Properties
White solid
Uses
3-Chloro-5-fluorobenzeneboronic acid is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
Uses
suzuki reaction
Synthesis
121-43-7
33863-76-2
328956-61-2
Grignard's reagent was prepared by dissolving 11.3 g of dried magnesium shavings and 75.0 g of 1-bromo-3-chloro-5-fluorobenzene (S1-1) in 220 ml of anhydrous tetrahydrofuran (THF) under nitrogen protection. The reaction system was cooled to -70 °C and 52.0 g of trimethyl borate dissolved in 200 ml of THF was slowly added dropwise. The reaction temperature of -70°C was maintained and stirred for 3 hours. Subsequently, the reaction system was gradually warmed to room temperature and stirring was continued for 12 hours. Upon completion of the reaction, 2N hydrochloric acid was slowly added dropwise to the reaction solution and stirred for 1 hour. The reaction mixture was extracted with ethyl acetate, the organic phase was washed with water and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure and the residue was washed with heptane to give 34.7 g of 3-chloro-5-fluorophenylboronic acid (S1-2) in 55.7% yield.
References
[1] Patent: EP2433923, 2012, A1. Location in patent: Page/Page column 68
3-Chloro-5-fluorophenylboronic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
View Latest Price from 3-Chloro-5-fluorophenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 3-Chloro-5-fluorophenylboronic acid
328956-61-2
|
$1.00 | 1KG | 97%-99% | 1kg; 5kg; 100kg | Career Henan Chemical Co |
-
- 3-Chloro-5-fluorophenylboronic acid
328956-61-2
- $1.00
- 97%-99%
- Career Henan Chemical Co
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