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ChemicalBook >> CAS DataBase List >>2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Structure
2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine structure
CAS No.
1053228-28-6
Chemical Name:
2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
Synonyms
EOS-60657;cas no 1053228-28-6;cas no 1053228-28-6 for sale;cas no 1053228-28-6 price USD;2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid;2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidine, 2,4,5-trichloro-;2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid, 10 mM in DMSO;2,4,5Trichloro7Hpyrrolo[2,3d]pyrimid,2,4,5 Trichloro 7H pyrrolo[2,3 d]pyrimid
CBNumber:
CB62489641
Molecular Formula:
C6H2Cl3N3
Molecular Weight:
222.46
MDL Number:
MFCD13193620
MOL File:
1053228-28-6.mol
MSDS File:
SDS
Last updated:2026-07-09 12:03:46
Request For Quotation

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Properties

Melting point 225 °C(Solv: dichloromethane (75-09-2))
Density 1.791±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 8.69±0.50(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 073809 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine 1053228-28-6 250.00mg $416 2026-05-18 Buy
Matrix Scientific 073809 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine 1053228-28-6 1.00g $899 2026-05-18 Buy
Matrix Scientific 073809 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine 1053228-28-6 5.00g $2411 2026-05-18 Buy
Biorbyt Ltd orb1298015 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid 99.65%(Mayvarybetweenbatches) 1053228-28-6 5mg $70 2026-05-06 Buy
Biorbyt Ltd orb1298015 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid 99.65%(Mayvarybetweenbatches) 1053228-28-6 1mlx10mM(inDMSO) $80 2026-05-06 Buy
Product number Packaging Price Buy
073809 250.00mg $416 Buy
073809 1.00g $899 Buy
073809 5.00g $2411 Buy
orb1298015 5mg $70 Buy
orb1298015 1mlx10mM(inDMSO) $80 Buy

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties, Uses, Production

Synthesis

2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE

90213-66-4

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine

1053228-28-6

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (2.0 g, 10.64 mmol) was used as a starting material, which was dissolved in dichloromethane/tetrahydrofuran (DCM/THF, 15 mL/6 mL) mixed solvent. Subsequently, N-chlorosuccinimide (NCS, 1.70 g, 12.76 mmol) was added to the solution. The reaction mixture was placed in a microwave reactor, heated to 90 °C and kept at this temperature for 2.5 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by fast column chromatography with the eluent being a 9:1 (v/v) hexane/ethyl acetate solvent mixture to afford 2,4,5-trichloro-7H-pyrrolo[2,3-d]pyrimidine (2.2 g, 93% yield) as a white crystalline solid. Mass spectrometry (MS) analysis showed m/z 223.48 [M + 1].

References

[1] Chemistry - A European Journal, 2015, vol. 21, # 34, p. 11976 - 11979
[2] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 584 - 589
[3] Patent: WO2016/130920, 2016, A2. Location in patent: Page/Page column 115
[4] Patent: WO2018/4306, 2018, A1. Location in patent: Page/Page column 127
[5] Organic Letters, 2016, vol. 18, # 9, p. 1976 - 1979

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine synthesis

39929-79-8
1053228-28-6
Synthesis of 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine from 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol N-Chlorosuccinimide 2,4-Dichloro-7H-pyrrolo2,3-dpyrimidine Tetrahydrofuran Dichloromethane

Preparation Products

2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Suppliers

Global Suppliers ( 85)
Supplier Tel Email Country ProdList Advantage
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Wuhan ariel chemical Co., LTD. 18986259541 18986259541 sales@3stc.com China 3827 58
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai Arbor Chemical Co., Ltd. 021-60451683 15021268886 sales@arborchemical.com China 837 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Worldyang Chemical Co.,Ltd. 021-56795766 sales@worldyachem.com China 9475 58
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Hangzhou Milestone Pharmtech Co., Ltd. 0571-82896630 18969958410 sales_hz@milestonepharmtech.com China 4908 55
Supplier Advantage
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Wuhan ariel chemical Co., LTD. 58
SynAsst Chemical. 55
Shanghai Arbor Chemical Co., Ltd. 55
Bide Pharmatech Ltd. 60
Shanghai Worldyang Chemical Co.,Ltd. 58
Cool Pharm, Ltd 58
Hangzhou Milestone Pharmtech Co., Ltd. 55

View Latest Price from 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid pictures 2026-07-08 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid
1053228-28-6
 $30.00-77.00 99.65% 10g TargetMol Chemicals Inc.
2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyriMidine pictures 2020-05-17 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyriMidine
1053228-28-6
 $1.00 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine pictures 2020-01-09 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
1053228-28-6
 $1.00 1KG 95-99% 1ton Career Henan Chemical Co

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Spectrum

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine(1053228-28-6)1HNMR

1053228-28-6 (2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine) Related Search:

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2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine 7H-Pyrrolo[2,3-d]pyrimidine, 2,4,5-trichloro- EOS-60657 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid 2,4,5Trichloro7Hpyrrolo[2,3d]pyrimid,2,4,5 Trichloro 7H pyrrolo[2,3 d]pyrimid cas no 1053228-28-6 for sale cas no 1053228-28-6 price USD cas no 1053228-28-6 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid, 10 mM in DMSO 1053228-28-6 pyrimidine Heterocycle-Pyrimidine series